Darilia

Darilia is an oral contraceptive, which contains a typical combination of drospirenone and ethinyl estradiol. Medicines with such a composition allow a woman to prevent unwanted pregnancy by acting on the processes of maturation of the endometrium (the inner layer of the uterus) and ovulation. When entering the body, the active substances act as the body's own hormones and have virtually no effect on health. In addition, the use of Darilia or other similar drugs may be indicated for some deviations in the menstrual cycle.

Indications Darilia

Darilia is prescribed as an oral contraceptive.

Release form

Darilia is available in the form of film-coated tablets.

Pharmacodynamics

The action of Dariliy is based on a complex combination of different factors, the main one of which is the suppression of ovulation and changes in the endometrium. The drug belongs to combined oral contraceptives, which contain the progestogen drospirenone and ethinyl estradiol.

In therapeutic dosage, drospirenone has a mild antimineralocorticoid and antiandrogenic effect. The substance does not have an estrogenic, antiglucocorticoid, glucocorticoid effect on the body, due to which drospirenone resembles the natural hormone progesterone in its action.

According to research, high doses of combined oral contraceptives reduce the likelihood of developing ovarian and endometrial cancer.

Pharmacokinetics

When taken orally, Darilia is absorbed quite quickly and completely in the gastrointestinal tract. In the blood, the active substance reaches its maximum value in about 60-120 minutes. Food intake does not significantly affect the bioavailability of the drug.

In the body, drospirenone binds to serum albumin (the substance does not bind to globulin).

Drospirenone is excreted from the body unchanged in urine and feces.

In case of kidney dysfunction, no particular deviations from the norm are observed. In case of moderate renal failure, the level of drospirenone in the blood is 37% higher compared to women whose kidneys functioned normally. Treatment with drugs containing drospirenone is usually well tolerated by patients with moderate renal impairment.

Ethinyl estradiol, like drospirenone, is rapidly and completely absorbed in the digestive system. The maximum level of the substance is observed in the blood after 60-120 minutes.

Studies have shown that the bioavailability of the substance was reduced after eating food in 25% of volunteers, while the remaining participants did not show any significant changes.

In the blood, ethinyl estradiol binds to serum albumin.

The substance is excreted in the form of metabolites by the kidneys and gall bladder (half-life is about a day).

Studies have shown no significant differences in pharmacokinetic properties after use by women of the Mongoloid and Caucasian races.

Dosing and administration

One blister of Darilia contains 24 tablets, which contain active ingredients and 4 placebo tablets.

The drug is prescribed daily, 1 tablet, preferably at the same time. The order of taking the tablets is indicated on each blister.

The drug is taken without interruption. Menstrual-like discharge begins a few days after starting to take placebo pills.

You should start using it from the first day of your period. After an abortion, if necessary, you can start taking the drug from the day of the operation (there is no need to use other methods of contraception).

The drug is taken daily, if the time of taking was missed, but less than twelve hours have passed since the missed pill, then you need to take the missed pill, while the decrease in contraceptive effect is not observed. If the interval exceeds twelve hours, then you should act depending on the day of the cycle.

If the drug intake was missed from the first to the seventh day, then it is necessary to drink it at the first opportunity, you can take two pills at once (the missed one and the next one). In this case, it is better to use additional contraceptives.

From the eighth to the fourteenth day, you should take the missed pill at the first opportunity, you can take two pills at once (the missed one and the next one). If there were no violations in taking the pills during the first week, you do not need to use additional contraception, in other cases, it is recommended to use protection.

From the fifteenth to the twenty-fourth day, if there were no missed pills during the first two weeks, there is no need to use other contraceptives.

If you miss a pill on these days, you can choose one of the following methods:

• take the missed pill as soon as possible (you can take two pills at once), then continue taking the active pills as usual, and then start taking the active pills from the next blister without taking the placebo. At this time, the likelihood of menstrual-like discharge is extremely low (minor bloody discharge is possible);
• start taking the placebo immediately, then start taking the pills from the new blister

If you miss a pill and there is no menstrual-like discharge during the usual break, pregnancy may have occurred, in which case you should consult a specialist.

If vomiting occurs after taking Darilia pills, the absorption of active components may not occur completely and it is better to use additional contraceptives.

If vomiting occurs within three to four hours of taking the pill, you should take another pill after your condition improves.

If there is a need to shift the day of the onset of menstrual-like discharge, you can skip the placebo and start taking active pills from a new blister immediately (you need to take the pills for as many days as it is desirable to shift the first day of menstruation). On these days, there is a high probability of bloody discharge.

After the day of menstruation has been shifted to the required day, the drug intake should be resumed according to the usual schedule.

To delay the onset of menstrual-like discharge, take a smaller amount of placebo. It is worth noting that the shorter the interval between taking active pills, the greater the likelihood of bleeding.

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Use Darilia during pregnancy

Darilia is not prescribed to pregnant women. Some epidemiological studies have shown that the use of combined oral contraceptives does not lead to the development of congenital pathologies in the child and does not have a negative effect on the course of pregnancy, however, experts recommend stopping the use of contraceptives when pregnancy occurs.

Contraindications

Dariliya is not prescribed for hypersensitivity to some components of the drug, venous or arterial thromboembolic diseases, angina pectoris, transient cerebrovascular accidents, cerebrovascular diseases, diabetes mellitus, high blood pressure, predisposition to arterial or venous thrombosis, pancreatitis, severe liver or kidney damage, cancer, vaginal bleeding with an unknown cause, pregnancy, migraines with local neurological symptoms in the past.

Side effects Darilia

Darilia in rare cases can provoke anemia, candidiasis, allergic reactions, endocrine system disorders, loss of appetite, changes in blood composition, sleep disorders, lack of orgasm, dizziness, tremors, dry mucous membranes, visual impairment, headaches, increased heart rate, vascular system disease, nosebleeds, fainting, digestive system disorders, inflammation of the gallbladder, redness, itching, acne and other skin rashes, pain during intercourse, inflammation of the vagina, bleeding, breast enlargement, pelvic pain, menstrual irregularities, vaginal discharge, vaginal dryness, necrosis of the inner lining of the uterus, ovarian cysts, increased sweating, weight gain or loss.

Also, in some cases, liver tumors, inflammation of the gastrointestinal tract (Crohn's disease), increased pigmentation of the skin, and chorea were recorded.

Darilia is well tolerated in most cases. Some women report lower abdominal pain, nausea, weight gain, and increased sexual desire after taking it, but the condition should usually return to normal after three months.

Overdose

There is very little data on cases of overdose of Dariliy. In some cases, vomiting and vaginal bleeding are observed. Treatment in this case is symptomatic.

Interactions with other drugs

Darilia, when taken simultaneously with other oral contraceptives, may cause bleeding or a decrease in the contraceptive effect.

Phenytoins, barbiturates, primidone, rifampicin, oxcarbazepine, felbomate, ritonavir, griseofulvin, topiramate, and preparations containing St. John's wort may increase the level of sex hormones.

During treatment with drugs that affect liver enzymes, it is recommended to use additional methods of contraception.

Penicillin and tetracycline antibiotics can reduce ethinyl estradiol levels.

Oral contraceptives may alter the metabolism of other drugs.

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Storage conditions

Dariliya should be stored in a place protected from moisture and sunlight. The storage temperature should not exceed 25 ⁰ C. The medicine is stored in the original packaging without violating its integrity.

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Shelf life

Dariliya is valid for two years from the date of manufacture and proper storage.