Dwella

Dwella belongs to a group of hormonal contraceptive drugs that are used for emergency contraception.

Indications Dwella

Dwella is prescribed for emergency contraception within five days of unprotected intercourse or in the case of an unreliable method of contraception (missed pill, faulty condom, etc.).

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Release form

Dwella is available in a strip packaging containing one tablet.

Pharmacodynamics

Dwella is a synthetic modulator, the drug has a specific effect on progesterone receptors. The principle of action is based on the suspension of the natural process of ovulation in women. Dwella delays the rupture of the follicle, provided that it is taken just before the expected date of ovulation.

The drug has high compatibility with progesterone and glucocorticosteroid receptors, lower compatibility is observed with androgen receptors, and is completely incompatible with mineralocorticoid and estrogen receptors.

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Pharmacokinetics

Dwella is rapidly absorbed in the digestive tract, with the maximum level of the active substance (ulipristal acetate) in the blood reached within 60 minutes.

Taking the drug with fatty foods reduces the bioavailability of the drug by 45%.

The absorption of ulipristal may be altered by increased gastric acidity.

In the blood, ulipristal binds to proteins by 98%.

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Dosing and administration

Dwella is taken within a few hours after sex (but not later than 5 days). One tablet of the drug is taken regardless of the phase of the menstrual cycle.

If vomiting occurs within the first three hours after taking the tablet, it is recommended to take another tablet.

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Use Dwella during pregnancy

Dwella is not prescribed to pregnant women. There is virtually no data on the effect of the drug on the fetus.

Contraindications

Dwella is contraindicated in case of hypersensitivity to some components of the drug, pregnancy, severe forms of liver or kidney failure, lactase deficiency, lactose intolerance, with impaired absorption of glucose, lactose, severe bronchial asthma, under 18 years of age.

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Side effects Dwella

Dwella can cause emotional disturbances, nausea, headache, abdominal pain, muscle pain, back pain, fatigue.

In rare cases, sleep disturbance, appetite disturbance, migraine, fever, skin redness, dry mouth, bowel disorder, cold, acne, itching, inflammation, vaginal discharge, bleeding, genitourinary infections, menstrual irregularities may occur.

Dehydration, tremors of the extremities, fainting, attention deficit disorder, redness of the mucous membrane of the eyes, perversion of smell, taste, photophobia, swelling of the upper respiratory tract, and increased sexual desire are extremely rare.

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Overdose

The drug Dwella has virtually no data on cases of overdose. No severe or undesirable consequences of taking the drug in a single dose (200 mg) were recorded.

Interactions with other drugs

When taking Dwell and rifampicin, phenobarbital, phenytoin, carbamazepine and other CYP 3A4 inducers simultaneously, the concentration of ulipristal in the blood may decrease.

Taking itraconazole, clarithromycin, nefazodone, ritonavir, ketoconazole, telithromycin can increase the effectiveness of the active substance Dwella in the body.

Taking medications to increase stomach acidity reduces the concentration of the active substance Dwella in the body.

Concomitant administration of digoxin, dabigatran etexilate and other P-glyoprotein substrates with Dwella is not recommended.

The active substance binds to progesterone receptors, and therefore the simultaneous use of Dwella and drugs that contain progesterone may change the effect of the drugs.

Dwella should not be taken at the same time as other rapid contraceptive drugs that contain levonorgestrel.

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Storage conditions

Dwella should be stored in a place protected from sunlight and moisture, the temperature should not exceed 30°C.

The drug should be stored in a closed place, out of the reach of small children.

Shelf life

The drug Dwella is valid for three years from the date of manufacture. The drug cannot be used after the expiration date or if stored incorrectly.

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