Medical expert of the article
New publications
Preparations
Dalfusin
Last reviewed: 03.07.2025
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Dalfusin is used for enlarged prostate gland.
Indications Dalfusin
Dalfusine is prescribed for benign formations in the prostate gland.
Release form
Dalfusine is available as film-coated tablets.
Pharmacodynamics
Dalfusin selectively blocks alpha 1 adrenergic receptors in the urethra, prostate gland, bladder, relieves spasms, reduces internal pressure, thereby improving urination.
The medication corrects urodynamic parameters: reduces tension in the urethra, resistance to urine outflow, facilitates the process of urination and emptying the bladder.
Pharmacokinetics
Dalfusin is well absorbed in the digestive tract. The active substance reaches its maximum value in the blood after an average of three hours.
About 90% of the drug binds to blood proteins. The half-life from the body is about 8 hours, 11% of the active substance (alfuzoschina) is excreted by the kidneys, the breakdown occurs mainly in the liver, most of the drug is excreted in the feces in the form of inactive metabolites.
In old age, higher concentrations of the active substance in the blood plasma and bioavailability of the drug are observed, the half-life remains the same.
In case of renal failure, the indicators of active substance excretion from the body and the volume of distribution increase. In severe forms of renal failure, the drug does not accumulate in the body due to increased biotransformation.
Dosing and administration
Dalfusin is prescribed to adult patients at 5 mg (1 tablet) twice a day. The medication should be taken after meals, it is not recommended to chew or break the tablets. It is best to start treatment with an evening dose.
In old age, with renal failure, when taking drugs to increase blood pressure, 5 mg is prescribed in the evening (if necessary, the doctor can increase the dosage to two tablets per day).
It is not recommended to take more than 10 mg of the drug per day.
[ 5 ]
Use Dalfusin during pregnancy
Dalfusin is not prescribed to pregnant women. No studies have been conducted on the safety of using the drug during this period.
Contraindications
Dalfusin is contraindicated in cases of increased sensitivity of the body to some components of the drug, low blood pressure, liver failure, as well as during the use of other alpha1 receptor blockers.
Side effects Dalfusin
Dalfusin can provoke headaches, tinnitus, weakness. In rare cases, fainting, drowsiness, and neuropsychic weakness are observed.
The medication also leads to a decrease in blood pressure, irregular or rapid heartbeat, and in case of ischemic heart disease, exacerbation of angina symptoms is possible.
In some cases, chest pain, swelling, skin rashes, itching, nausea, upset stomach, stomach pain, and dry mouth are observed.
Overdose
When taken in excess of the recommended dose, Dalfusin leads to a decrease in blood pressure. Treatment in case of drug overdose is symptomatic (administration of vasoconstrictors, solutions of high-molecular substances, etc.). Artificial blood purification is ineffective in this case.
Storage conditions
Dalfusin should be stored closed and dry in a place where sunlight does not penetrate. The storage temperature should not exceed 25°C. The medicine should be stored in a place away from small children.
Shelf life
Dalfuzin is valid for two years from the date of manufacture.
Attention!
To simplify the perception of information, this instruction for use of the drug "Dalfusin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.