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Dalfaz retard
Last reviewed: 23.04.2024
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Dalfaz retard is an alpha-blocker. Preparations from this group block adrenergic synapses, which leads to the expansion of precapillary and arterioles. In addition, Dalfaz retard improves the process of excretion of urine with an increase in the prostate gland.
Dalfaz retard helps to improve the condition of patients with benign education in the prostate gland. The medication improves overall well-being, facilitates urination, relieves soreness.
Indications Dalfaz retard
Dalfaz retard is used to treat benign education in the prostate gland.
Release form
The medication is available in the form of tablets, coated with a coat of light beige color.
Pharmacodynamics
The active substance of Dalfaz retard is alfuzosin, which shows activity when taken orally.
Alfuzosin blocks adrenoreceptors located in the triangle of the bladder, the prostate gland, the urethra.
With benign formation in the prostate gland, a smooth muscle contraction occurs, which prevents the flow of urine and leads to disruption of the bladder.
Dalfaz retard directly affects the smooth muscles of the prostate gland and improves the outflow of urine, reduces pressure in the urethra, eases urination.
Pharmacokinetics
Dalfaz retard reaches the highest concentration in the body 3 hours after ingestion. The half-life of the drug in the body is eight hours.
The therapeutic effect of the drug is not dependent on food intake.
The active substance (alfuzosin) of the drug disintegrates mainly in the liver, 11% of the substance is excreted by the kidneys in an unchanged state, 80-90% - in the form of metabolites with feces.
At the age of more than 75 years, the absorption period of the drug is reduced, and the highest concentration in the body is higher.
In case of serious violations of the liver, the half-life and bioavailability are increased in comparison with healthy patients.
If the kidneys are disturbed, the process of cleansing the body and the level of distribution of the drug are increased.
Dosing and administration
Dalfaz retard tablet is taken whole by mouth, it is recommended to drink one glass of water. In day you need to take 2 tablets (morning and evening).
Adult patients are prescribed 5 mg of the drug (one tablet) twice a day.
In the elderly, with reduced blood pressure, when taking medications to reduce blood pressure, one tablet is prescribed in the first days (preferably in the evening), then, taking into account the clinical response, the specialist can increase the dosage, but not more than two tablets per day.
With renal failure, dose adjustments are not required.
When liver failure is prescribed, 1/2 tablet (2.5 mg) once a day, then the specialist can increase the dose (not more than 1 tablet per day).
Disturbance of the structure of the tablet can affect the rate of absorption and provoke the development of adverse reactions, so you can not grind, snap, etc. Tablets before admission.
Use Dalfaz retard during pregnancy
Pregnant women were not studied for safety of Dalfaz retard therapy.
Contraindications
Precautions should be taken with blood pressure at the same time as blood pressure lowering drugs, in elderly patients, with ischemia, with angina, with ischemic brain disease on the background of a decrease in pressure.
Side effects Dalfaz retard
Dalfaz retard quite often provokes dizziness, weakness, headaches. In rare cases, there is cerebral ischemia, drowsiness.
Also, problems with vision, lowering blood pressure, increased heart rate (rarely attacks of angina in ischemic heart disease), inflammation of the nasal mucosa, nausea, upset of the stool, skin rashes, a sense of fatigue.
In rare cases, liver disease, damage to liver cells, angioedema, redness of the skin, swelling and soreness in the chest, a painful erection not associated with sexual arousal can develop.
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Overdose
Dalfaz retard when taken in an elevated dose causes a decrease in blood pressure, rapid heart rate.
In case of an overdose, hospitalization of the patient and treatment in hospital with vasoconstrictive drugs and plasma substitutes is necessary, after improvement of the condition it is recommended to observe the patient for a minimum of 24 hours.
Purification of the blood in this case is ineffective, since the active substance binds to proteins in a high degree.
Interactions with other drugs
Dalfaz retard can not be taken concomitantly with urapidil, prosazin and other alpha1-adrenoreceptor blockers.
Caution should be taken Dalfaz retard with drugs to lower blood pressure, ketoconazole, itraconazole, ritonavir.
Simultaneous reception of nitrates can provoke a rapid rhythm of cardiac contractions, lowering blood pressure.
Anesthesia during medication treatment can cause instability of blood pressure.
Storage conditions
The medicine should be stored in a place protected from moisture and sunlight, the storage temperature should not be more than 25 ° C.
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Shelf life
The medication is suitable for three years from the date of manufacture. If there is a violation of the packaging or failure to comply with the storage conditions, as well as after the expiration date, it can not be used.
Attention!
To simplify the perception of information, this instruction for use of the drug "Dalfaz retard" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.