Cycloferon

Cycloferon is an antiviral medication with immunomodulatory activity. The drug induces high molecular weight the formation of internal interferon.

Powerful activation of immune activity leads to the development of anti-chlamydial and antimicrobial effects. The medicine has an anticarcinogenic and anti-meta static effect, which prevents the development of neoplasms. In addition, the medication prevents the occurrence of autoimmune reactions, due to which in people with systemic diseases affecting connective tissues and diseases of a rheumatic nature, pain is weakened and inflammation is reduced.[1]

Indications Cycloferon

Tablets are used in combination therapy for such disorders (adults):

• herpes-type infections;
• neuroinfection;
• active forms of infections in the intestinal area;
• ARI, as well as influenza;
• symptoms of secondary immunodeficiency under the influence of bacterial and mycotic infections;
• chronic stages of hepatitis C and B (viral form);
• HIV in phase 2A-3B.

For combined treatment in children (exclusively with the appointment of a medical specialist) it is used for the following diseases:

• active and chronic stages of hepatitis C and B viruses;
• herpetic infections;
• HIV phase 2A-3B;
• active stages of intestinal infections;
• influenza with acute respiratory infections (for prevention and therapy).

Intramuscular injections for combined treatment are prescribed for the following disorders (adults):

• neuroinfection;
• hepatitis viruses types C and B, as well as D and A;
• HIV in clinical phase 2A-3B;
• rheumatoid arthritis and lupus erythematosus;
• herpes and cytomegalovirus infections;
• signs of a secondary form of immunodeficiency caused by bacterial and mycotic effects;
• having a degenerative-dystrophic form of joint damage;
• infection of chlamydial origin.

For a child over 4 years old, the medication is used in combination with other therapeutic substances for viral hepatitis, herpes and HIV.

Local application of the drug is made for balanoposthitis or urethritis, as well as herpes, nonspecific vaginosis and vaginitis of a bacterial nature.

Release form

The release of the medication is made in tablets, 10 pieces inside cell packs or 50 pieces inside polymer glass jars.

It is also sold in the form of a liquid for intramuscular injections, inside ampoules with a volume of 2 ml. There are 5 such ampoules inside the box.

It can be produced in the form of a 5% gel - inside 5 ml tubes.

Pharmacodynamics

Inside the body, the drug demonstrates a wide range of bioactivity - it has antitumor, anti-inflammatory, antiproliferative, immunomodulatory and antiviral effects.

Cycloferon enhances the production of interferons within the body. Their greatest number is observed inside tissues and organs with lymphoid components (liver, lungs, intestinal mucosa and spleen). The influence of the drug leads to the activation of bone marrow stem cells and the processes of production of granulocytes. In persons with immunodeficiencies of various natures, the medicine helps to adjust the immune activity. The drug can overcome the BBB.[2]

With the local use of the gel, the immune activity is enhanced, anti-inflammatory and antiproliferative effects develop.

Pharmacokinetics

With oral administration of the highest permissible dosage of the drug, the plasma Cmax of the active element is observed after 2-3 hours.

The decrease in this indicator occurs gradually, by the 8th hour after administration. Traces of the drug are recorded inside the body after a day.

The half-life is 4-5 hours. When using drugs in the recommended portions, the active ingredient does not accumulate.

Dosing and administration

Schemes for the use of tablets of the drug.

The medicine should be used in 1 tablet a day, before eating food (0.5 hours). The tablet is not chewed, but swallowed whole with plain water.

In the case of the viral form of hepatitis C or B, as well as for herpes, the medication is taken every day, 2-4 tablets. The standard usage pattern is as follows: 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th and 23rd days.

In the case of hepatitis, after the main course, supportive treatment is performed, which lasts 3.5 months. During this period, it is necessary to use 1 tablet per day with 3-5-day intervals. If necessary, a second course can be prescribed.

With acute respiratory infections or influenza, 2-4 tablets are taken once a day; the whole cycle consists of 10-20 tablets. Therapy begins immediately after the first signs of the disease appear. Together with Cycloferon, the patient should take expectorant drugs, antipyretics and analgesics.

Standard treatment regimen for intestinal infection: taking 2 tablets in the 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th, and also the 23rd days. The same scheme is used in the case of neuroinfections, but at the same time, on certain days, the patient needs to take 4 tablets. Then the patient is transferred to supportive therapy, with the intake of 4 tablets of drugs at 5-day intervals. All therapy as a whole can last 2.5 months.

In the case of HIV, use the same regimen. Upon its completion, a few weeks later, a repeated cycle is carried out in the same mode.

Serving sizes for a child: age 4-6 years - 1 tablet 1 time per day; 7-11 years old - 2 tablets; over 12 years old - 3 tablets. If there is a need for a second course, it is prescribed only after 2-3 weeks after the end of the first cycle. Given the underlying pathology, the doctor selects a standard regimen for the use of drugs.

The use of the medicine in injections.

The therapy is carried out, taking into account the underlying pathology, but the medication must be administered according to the standard scheme: in the 1st, 2nd, 4th, 6th, 8th, 11th, 14th, 17th, 20th th, 23rd, 26th and 29th days. It is necessary to open the ampoules immediately before the injection procedure (i / m or i / v), which is performed 1 time per day.

Given the disease, the main treatment cycle consists of 10-12 injections. It is necessary to combine the medication with antibacterial substances. If necessary, the doctor can prescribe several cycles using the drug in ampoules.

The size of the injection dosage for a child is selected taking into account his weight - 6-10 mg / kg per day.

Methods of using the medicine in the form of a gel.

It is necessary to treat the directly affected skin area with a thin layer of gel. A similar procedure is performed within 5 days, every day, once a day.

With herpes of the genital type, intraurethral or intravaginal instillations of the 1st bottle of the drug are performed, once a day, in a period of 10-15 days.

With nonspecific and candidal forms of urethritis, 1-2 vials of the medication are injected into the urethra.

In people with specific types of urethritis, Cycloferon is used additionally, in combination with other drugs.

With the bacterial form of vaginosis and colpitis of a nonspecific or candidal type, the gel is used both in monotherapy and in combination with other medicines.

Sometimes it is allowed to soak cotton swabs with gel, which are then used as suppositories.

• Application for children

The drug in tablets and injections is not used in children under 4 years of age.

Use Cycloferon during pregnancy

It is prohibited to prescribe Cycloferon during HB and pregnancy.

Contraindications

The main contraindications:

• decompensation phase of hepatic cirrhosis;
• severe intolerance to the elements of the medication.

With restrictions, it is used for exacerbation of pathologies in the digestive system. It is carefully prescribed to persons who have a history of allergic manifestations.

Side effects Cycloferon

The medication can cause allergy symptoms. Side effects usually occur only occasionally. With their development, it is required to immediately consult a medical professional.

Interactions with other drugs

The use of the drug potentiates the therapeutic effect of nucleoside analogs and interferons.

The medication weakens the severity of side effects during chemotherapy and interferon therapy.

Storage conditions

Cycloferon should be kept out of sunlight and moisture; temperature indicators - no more than 20 ° C. A short freezing of the injection liquid is allowed if needed. In this case, it is necessary to defrost the medicinal ampoules gradually, only at room temperature. If a precipitate appears inside the ampoule or the color of the solution changes, it is prohibited to use it.

Shelf life

Cycloferon in the form of a gel and tablets can be used within a 2-year term from the date of manufacture of the drug. The shelf life of the solution is 36 months.

Analogs

The analogs of the drug are Anaferon, Timogen, Immunin with Galavit, and in addition Otsillokotsinum and Amiksin. Also on the list are Inflamafertin and Protphenoloside.

Reviews

Cycloferon receives mostly diverse reviews. With regard to pills, they mainly write that the medicine does not cause the development of negative signs. If used correctly in accordance with the recommendations, after the treatment cycle, there is a noticeable improvement in a variety of pathologies.

Doctors generally positively assess the injections of the medication, although it is indicated that they should be used only in cases where there are appropriate indications. Injections should not be given to children under 4 years of age. In addition, it is forbidden to consume alcoholic beverages against the background of ongoing therapy, since this sharply reduces the effectiveness of the drug.

In the reviews regarding the gel, it is noted that it is very effective in the treatment of herpes and infections in the area of the urogenital system. But a noticeable effect of the drug develops only in the case of its constant use.