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Health

Cole from alcoholism

, medical expert
Last reviewed: 09.08.2022
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The drug Kolme from alcoholism refers to a group of pharmacological agents that are used for the aversive treatment of addictive (addictive) disorders.

The manufacturer of the drug is Faes Farma / Laboratorios Vitoria (Spain-Portugal), the international name is Cyanamid.

trusted-source[1], [2], [3], [4]

Indications Cole from alcoholism

Indications for the use of Colem from alcoholism - chronic alcohol dependence and prevention of recidivism of alcoholism, as well as prolongation of remission and prevention of disruptions in psychotherapeutic treatment of alcoholism. The mechanism of physiological intolerance of alcoholic beverages is formed by affecting the body, as a result of which its sensitivity to ethyl alcohol increases.

trusted-source[5]

Release form

The form of this product - drops for oral administration in ampoules of 15 ml; in one package there are 4 ampoules with a solution (total volume of 60 ml) and a dosage bottle-dropper. This form of the drug is the only one, Kolmé's alcohol pill is not available.

Pharmacodynamics

As the instruction to Colma of alcoholism informs, the main active substance of the drug is cyanamide; auxiliary components - sorbic acid (preservative E200), acetic acid ice (solvent), sodium acetate (preservative E262) and water for injection. In one drop of Cole from alcoholism contains 3 mg of cyanamide.

Exposure to the body provides cyanamide: getting into the body, cyanamide binds to the proteins of the oxidative enzyme of hepatocytes acetaldehyde hydrogenase (ALDH) and blocks their sulfhydryl groups. As a result, the process of dehydrogenation of ethanol to carbon dioxide and water is inhibited, the level of the toxic metabolite of ethanol, acetic aldehyde (acetaldehyde), increases in the liver and begins to exert a toxic effect on the body. With the next use of alcohol (approximately 45-60 minutes), the skin of the face and the top of the trunk turn red, the pulse becomes more frequent, there is a headache, chest pain, nausea and vomiting, a feeling of suffocation and cyanosis, blood pressure changes abruptly, possibly a collapse state. This reaction occurs spontaneously on average after 60 minutes. The manifestation of such a reaction to alcohol, repeated repeatedly, is incorporated into the method of aversive therapy of alcohol-dependent people and should form a strong aversion to alcohol (its smell and taste) at the level of the conditioned reflex.

COLME drops from alcoholism (one-time administration) provide an increased sensitivity of the body to ethanol within 12 hours, which after this time passes.

Pharmacokinetics

The pharmacokinetics of alcohol in the instruction to the drug is not explained, although it is known from other sources that cyanamide penetrates into the blood plasma and its bioavailability is at least 70%, and the total plasma clearance varies from 42 to 62 minutes.

Also, the instructions to Colma from alcoholism do not report that the active substance of this preparation cyanamide is a cyanide amide, and it is obtained by hydrolysis of calcium cyanamide, a toxic substance that is part of pesticides and herbicides. Compounds of cyanic acid, especially when interacting with ethyl alcohol, cause a state similar to that which occurs when poisoning with pesticides.

Dosing and administration

Drops of Cole from alcoholism should be taken orally 2 times a day, the interval between the methods should be at least 12 hours. The standard dose is 15 drops per dose. Drops are added to cold non-alcoholic drinks or cold dishes. Duration of treatment is 3 months. The drug is taken without interruption.

trusted-source[8], [9]

Use Cole from alcoholism during pregnancy

Use of colem from alcoholism during pregnancy is unacceptable.

Contraindications

Drops of Cole from alcoholism are contraindicated to use with individual hypersensitivity to the substances in the drug and in the presence of severe pathologies of the cardiovascular system, lungs, liver and kidneys.

trusted-source[6]

Side effects Cole from alcoholism

Side effects of colem from alcoholism are manifested in the form of increased drowsiness and a sense of loss of strength, noise in the ears and decreased visual acuity, decreased appetite and feelings of discomfort in the stomach, rashes on the skin, increased diuresis, decreased libido, temporary leukocytosis, or granulocytopenia.

Simultaneous reception of Colem from alcoholism with alcohol is a significant health hazard in diabetes mellitus, epilepsy, diseases of the cardiovascular system and kidneys, as well as hyperthyroidism (hyperthyroidism).

trusted-source[7]

Overdose

Overdose of the drug may increase the intensity of manifestations of side effects. Symptoms of an overdose by the manufacturer are not described, but if the dose is exceeded, the stomach should be washed and measures taken to maintain the heart, lungs and liver. If necessary, blood transfusion is indicated.

trusted-source[10], [11]

Interactions with other drugs

Colme's interaction with alcoholism with ethyl alcohol is described above, so any alcohol-based medications should be avoided.

In addition, Colmus drops from alcoholism are not prescribed simultaneously with taking an anti-TB drug isoniazid and an antiepileptic drug phenytoin, as well as with other pharmaceutical agents - acetaldehydehydrogenase enzyme inhibitors (teturam, metronidazole).

trusted-source[12], [13], [14], [15]

Storage conditions

Storage conditions for Colem from alcoholism: at a temperature not exceeding + 25 ° C, in a place protected from light.

trusted-source[16], [17]

Special instructions

In the process of treatment of alcoholism, motivation and a psychological attitude towards a sober lifestyle are very important. Therefore, most narcologists do not recommend relatives of chronic alcoholics to give them any kind of drugs without the knowledge of a drinking person.

And Kolme from alcoholism, like all the means used in the aversive therapy of chronic alcohol dependence, does not guarantee a complete victory over the craving for alcohol, but contributes to the creation of a subconscious (conditioned-reflex) barrier between man and alcohol.

The price of colem from alcoholism in the pharmacy network ranges from 345-385 UAH. For packing.

Shelf life

Shelf life of the drug is 24 months, and after the opening of the ampoule and transfusion into the vial dispenser - no longer than 30 days. The bottle should be tightly closed.

trusted-source[18]

Attention!

To simplify the perception of information, this instruction for use of the drug "Cole from alcoholism" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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