Codelac for coughing

The cough medicine Codelac has several variants differing in composition: Codelac, Codelac Fito (Codelac with thyme), Codelac Neo, Codelac Broncho. They are available in different forms and are used both for non-productive (dry) cough and productive (wet) cough.

Let's consider each of the named drugs in detail, so that patients know: which Codelac from what cough is used.

Codelac for dry cough

It is a narcotic cough suppressant called Codelac cough tablets with codeine phosphate (opium alkaloid), sodium hydrogen carbonate, and powder of licorice or licorice root (Glycyrrhiza) and Thermopsis lanceolatae herb (Thermopsidis lanceolatae).

Indications for use of this remedy include diseases of the respiratory organs and respiratory tract with dry (non-productive) cough.

• Pharmacodynamics

Pharmacological action of Codelac is combined. Codeine phosphate, acting on opioid receptors of the CNS, reduces excitation of the cough center of the medulla oblongata. As an expectorant component act triterpene compounds glycyrrhizinic acid contained in licorice root, as well as polyphenols (in particular, liquiritin), which improve mucociliary clearance of the upper respiratory tract and relieve bronchial spasms. Alkaloids of the herb thermopsis excite the respiratory center of the brain, and saponins and essential oils of the plant increase the production of bronchial secretion and promote its expectoration And due to the presence of sodium bicarbonate in the composition of Kodelak sputum becomes more alkaline and less dense, which makes it much easier to remove it from the respiratory tract.

• Pharmacokinetics

Codeine phosphate is rapidly adsorbed in the gastrointestinal tract, and after 60 minutes its concentration in plasma reaches a maximum, and the elimination half-life with an average of 3.5 hours. In the process of transformation by hepatic enzymes codeine is metabolized to morphine and norcodeine, which in conjugated and partially free form are excreted from the body by the kidneys.

• Use during pregnancy

Codelac with codeine phosphate is prohibited during pregnancy and lactation.

• Application for children

This medicine is not prescribed for children under 24 months of age.

• Contraindications to use

Use of Codelac is contraindicated in the presence of bronchial asthma and insufficient respiratory function, as well as in cases of enzymatic liver failure and cerebral hypertension.

• Side Effects

There are such side effects of Codelac tablets with codeine phosphate as headache and dizziness, increased drowsiness, nausea and vomiting, bowel disorders (constipation) and epigastric pain; allergic reactions with skin rashes and angioedema are possible.

• Method of application and doses

Tablets are taken orally, drinking water. The standard single dose for an adult is one tablet, the number of doses per day is two to three, and the course of treatment is no more than five days.

• Overdose

Exceeding the dose of this medicine may lead to deterioration of respiratory function, decrease in general body tone, dry mouth, miosis and nystagmus, facial hyperemia, hyperhidrosis, decrease in HR, convulsions, nausea and vomiting. Administration of activated charcoal is effective only in the first 60 minutes after the onset of overdose symptoms. The antidote for codeine is Naloxone (which is administered by injection).

• Interactions with other drugs

Codelac should not be taken with other cough medicines (with secretolytic and expectorant action), central analgesics, barbiturates, antipsychotics and agents containing alcohol.

• Storage conditions

Codelac tablets should be stored at room temperature, out of the reach of children.

The shelf life of the drug is 4 years.

Analogs: syrup Cofex, tablets Codterpin.

Codelac with thyme for cough (Codelac Fito)

Codelac Fito is also used for cough without phlegm. It is available in liquid form - as an elixir.

Since the composition of the drug is the same as in Kodelak tablets, the mechanism of pharmacological effect of Kodelak Phyto does not differ much from the tablets. An additional ingredient - a liquid extract of thyme or thyme herb (Thymus vulgaris) - increases the production of bronchial mucus, promotes its liquefaction and thus relieves coughing.

Use during pregnancy is contraindicated.

The use for children is allowed only from the age of two years and exclusively on the prescription of a doctor, assessing the child's condition and the nature of the cough, which is not reduced by the use of other medicines.

Contraindications to use, side effects and signs of overdose are the same as for Codelac tablets.

• Method of application and doses

Codelac Fito is taken orally an hour and a half before a meal or at the same interval after a meal. Dosage: for adults and children over 12 years - 5 ml (three times a day); for children from 5-12 years - 5 ml, but twice a day; 2-5 years - twice a day 2.5 ml.

• Storage conditions

Codelac Fito should be stored at +8-15°C.

Shelf life of the elixir in an unopened bottle - 18 months, in an opened bottle - 3 months.

Codelac Neo for cough

Non-narcotic drug Codelac Neo is used for dry cough of any origin, especially in whooping cough, acute bronchitis and laryngitis, as well as to suppress the cough reflex before bronchoscopic examination and pulmonologic surgical interventions.

• Form of release

Codelac Neo tablets (0.05 g each) and liquid forms - cough drops and syrup.

• Pharmacodynamics

Antitussive effect of the drug is due to nonspecific anticholinergic and bronchospasmolytic action: through receptors in the brainstem its active substance - butamirate (5-bromo-4-chloro-2-methoxybenzonitrile) in the form of citrate - affects the cough center. In addition, butamirate reduces the resistance of airway muscle fibers, suppressing bronchospasm.

• Pharmacokinetics

Butamyrate is rapidly and almost completely absorbed after oral administration and binds well to plasma proteins (98%). The maximum concentration in blood after a single dose is reached within 9 hours.

The plasma elimination half-life is about 13 hours; 90% of butimiradate biotransformation products are excreted with urine.

• Use during pregnancy

Preparations containing butimirate are not prescribed for pregnant and lactating women.

• Application for children

Codelac Neo is not used to treat children in the first two months of life; the syrup is not used for children under three years of age, and the tablets are not used until age 18.

Contraindications to use - hypersensitivity to the drug.

Possible side effects are rarely observed, mainly in the form of skin rash, dizziness, drowsiness, nausea and diarrhea.

• Method of application and doses

All forms of the medication are taken orally (before meals).

Tablet dosage: one tablet every 12 hours.

Syrup dosage: children over 12 years - 15 ml twice a day; 6-12 years - 10 ml;

3-6 years - 5 ml.

Dosage of drops: children 3-12 months. - 10 drops (dissolving in a small amount of liquid), three times a day; up to three years - 15 drops; over three years - 20 drops.

• Overdose

Dizziness, nausea, vomiting, diarrhea, drowsiness, abdominal pain, arterial hypotension, impaired motor coordination are among the signs of overdose of Codelac Neo. Gastric lavage and administration of absorbents are indicated.

• Interactions with other drugs

This medicine is incompatible with ethyl alcohol and psychotropic drugs.

• Storage conditions

The drug Codelac Neo should be stored at room temperature, out of reach of children.

• Shelf life

The shelf life is two years for tablets and five years for other forms.

Other trade names (synonyms) of Codelac Neo: Butimirate, Sinekod, Stoptussin, Omnitus, Intussin, Panatus, Brospamine.

Codelac Broncho for cough

Codelac Broncho from cough (in tablet form) - a combined remedy with mucolytic properties. This is Codelac for wet cough with viscous sputum, which is a symptom of respiratory diseases of the upper respiratory tract, bronchitis, tracheobronchitis, pneumonia.

• Pharmacodynamics

This product contains ambroxol, sodium glycyrrhizinate (glycyrrhate), sodium hydrogen carbonate and dried extract of thermopsis herb. Ambroxol stimulates the synthesis of bronchial secretion, which becomes less dense and easier to expectorate; sodium bicarbonate liquefies accumulated mucus, and sodium glycyrrhizinate has an anti-inflammatory effect and reduces the level of oxidative stress of cells of the respiratory epithelium.

• Use during pregnancy

Codelac Broncho is contraindicated in pregnancy and during breastfeeding.

Use for children is possible only after 12 years of age.

• Contraindications to use

Codelac Broncho is contraindicated in the treatment of allergic cough and in hypersensitivity to the components of the drug.

• Side Effects

Side effects of this medicine may be manifested by dryness in the nasopharynx or nasal discharge, headache and general weakness, problems with urination and the development of allergic reactions.

• Method of application and doses

Codelac Broncho is taken with meals three times a day (not longer than five days), single dose - one tablet.

• Overdose

In case of exceeding the dose, nausea, vomiting and diarrhea may occur. Gastric lavage should be performed within two hours from the onset of these symptoms.

• Storage conditions

To store this drug you need a dry place, the optimal temperature is room temperature.

The shelf life is 24 months.