Cesolin

The drug Cesolin refers to antimicrobial β-lactam drugs, and, in particular, to the group of cephalosporin antibiotics of the first generation. The active component of the preparation is a derivative of 7-aminocephalosporanic acid.

[1]

Indications Cesolin

Cesolin is indicated for the following diseases:

• Infectious microbial damage of the respiratory system and otorhinolaryngological organs (tonsillitis, tonsillitis, pharyngitis, inflammation of the lungs and bronchi, empyema of the pleura, lung abscesses, otitis, sinusitis).
• Infectious diseases of the urinary and bile excretory system.
• Infections of the abdominal organs, skin, osteoarticular system (peritonitis, osteomyelitis, pyoderma, boils, abscesses).
• Syphilis, gonorrhea.
• Infectious complications after burns, wounds or surgical interventions.
• Preventative measures taken before or after surgery.

[2], [3], [4]

Release form

The preparation is available as a lyophilized mass for the preparation of injectable solutions. The mass is packaged in vials, which are placed in individual cardboard packages.

One bottle with lyophilized mass may contain an active component of cefazolin 0.5 g or 1 g.

The drug is manufactured in India by the pharmaceutical company Lupine Ltd.

[5], [6], [7], [8], [9],

Pharmacodynamics

Tsezolin - a representative of the cephalosporin group of the first generation of antibiotics for internal use. Kills bacteria, preventing the process of synthesis of the wall of a microbial cell. Has a wide range of antimicrobial effects. It is active against gram (+) staphylococci, streptococci, corynobacteria, as well as to gram (-) shigella, salmonella, escherichia, klebsiella, treponema, leptospira, etc. Effective in fighting some strains of enterobacteria and enterococci.

Does not show activity against indolpositive strains of the protein, mycobacteria, anaerobic bacteria, as well as methicillin-resistant strains of staphylococci.

[10], [11], [12], [13]

Pharmacokinetics

After intramuscular injection of Cesolin in an amount of 0.5 and 1 g, the limiting plasma concentration of the active substance may be 38 and 64 μg / ml. The peak content of cefazolin is observed 60-120 minutes after injection.

After intravenous injection of the drug in an amount of 1 g, the peak concentration is 180 μg / ml, which can be observed already after 6 minutes after the injection.

The active substance is able to penetrate into the joint bags (usually after one and a half to two hours, in newborn children - after 4-5 hours, in patients with disorders of renal function - from 3 to 42 hours), in the vascular walls and heart tissues, in the organs abdominal cavity, urinary system, placenta, skin and mucous membranes.

The drug is excreted via the urinary system in a preserved form, mainly for up to six hours after administration (up to 90%). After a day, the withdrawn amount of the drug reaches 95%.

[14], [15], [16], [17], [18]

Dosing and administration

The drug can be administered by intramuscular or intravenous injection (either by jet or by drip).

The standard daily dosage for an adult patient is from 1 to 4 g, with a maximum daily dosage of up to 6 g. The drug is administered about 3 to 4 times a day. The course of therapy is 1-2 weeks.

As a preventive measure in the postoperative period, Tzozolin is administered intravenously: in the amount of 1 g half an hour before the start of surgery, as much during the operation, and from 500 mg to 1 g during the first 24 hours after surgery, at 8-hour intervals time.

In patients with functional renal impairment, the dosage of the drug is adjusted depending on the creatinine clearance: there is no need to adjust the dosage regimen of Cesolin at a clearance of 55 ml per minute or higher, or with a serum creatinine level of 1.5 mg% or less. If the clearance drops to 35 ml per minute, and the creatinine level reaches 3 mg%, then the dosage can be left unchanged, limited to lengthening the intervals between administrations (not less than 8 hours). With a clearance of up to 11 ml per minute and a creatinine level of up to 4.5 mg%, half the prescribed dosage is administered at intervals of 12 hours. If the clearance is 10 ml per minute or less, and the serum creatinine level increases to 4.6 mg% or higher, then half the prescribed amount of the drug is administered at time intervals from 18 to 24 hours.

Treatment usually begins with a trial injection of 500 mg of the drug. In pediatrics from 1 month and more, from 25 to 50 mg per kilogram of body weight per day. In the presence of complications, the dosage of the drug may increase to 100 mg per kilogram of body weight per day. Frequency of injections - up to 3-4 times a day.

If the child has a disorder of kidney function, then the amount of the drug administered is tied to the rates of blood purification:

• at a clearance of 70 to 40 ml per minute only 60% of the previously prescribed dosage is used with a time interval of 12 hours;
• at a clearance of 40 to 20 ml per minute, only 25% of the previously prescribed dosage is left with a time interval of 12 hours;
• at a clearance of 5 to 20 ml per minute apply 10% of the previously prescribed dosage once a day.

All these dosages are used after a single injection of the "shock" dosage.

To prepare injection and infusion solutions, 500 mg of lyophilizate is diluted in 2 ml of injection water, and 1 g of lyophilizate - in 4 ml.

With intravenous administration, the resulting drug should be diluted in 5 ml of injection water. Introduce neatly, slowly, for 4-5 minutes.

For drip injection, the lyophilizate is diluted in 100 ml of a dextrose solution, an isotonic solution or a Ringer ring. The lyophilized mass must completely dissolve in the liquid. If there are insoluble elements in the solution, then such a preparation should not be used.

[23], [24], [25], [26], [27],

Use Cesolin during pregnancy

You should avoid the use of Cesium during pregnancy. The facts of penetration of the active component of the drug through the placental barrier have been proved.

During lactation, the drug in small amounts is determined in the mother's milk.

The use of zeolite by pregnant and lactating women is not welcome, and can be prescribed only if the intended benefit for a woman is significantly higher than the possible danger to the embryo or newborn baby.

Contraindications

Medication Cesolin is not used:

• with a tendency to allergy to cephalosporin antibiotics;
• in infants up to 1 month;
• in severe disorders of renal function and chronic colitis.

[19], [20]

Side effects Cesolin

Cesolin can cause the following side effects:

• Development of allergies: redness of the skin, rashes, itching rash, shortness of breath, swelling, joint pain, anaphylaxis, signs of multiform exudative erythema, eosinophilia.
• Convulsive seizures.
• With the phenomena of renal dysfunction: deterioration of the condition.
• Dyspeptic manifestations, attacks of nausea and vomiting, epigastric pain, cholestasis, hepatitis.
• Blood test: signs of leukopenia, neutropenia, hemolytic anemia, a decrease or increase in the level of platelets in the blood.
• Violation of the microflora of the intestinal, vaginal and oral cavity.
• Hyperactivity of hepatic transaminases, the presence of creatine in the blood, an increase in the prothrombin index.
• Pain at the injection site, development of venous wall inflammation with intravenous injection.

[21], [22]

Overdose

In case of an overdose, there may be an increase in side effects, the development of allergic reactions and anaphylaxis.

A special drug that neutralizes the effect of Cesolin does not exist. In cases of overdose, symptomatic therapy is used, with digestive disorders - milk every 3 hours.

[28], [29],

Interactions with other drugs

Do not use a combination of Cesolin with anticoagulant and diuretic drugs. With the simultaneous use of Cesolin with loop diuretics, it is possible to block tubular secretion.

Groups of aminoglycosides increase the risk of pathological damage to the renal system. In addition, Cesolin and aminoglycosides mutually inhibit each other.

Medical drugs that can block tubular secretion can increase intoxication of the body and slow the elimination of toxic substances and metabolic products.

[30], [31], [32]

Storage conditions

Medication-lyophilizate can be stored necessarily in dry ventilated places, with temperature up to 30 ° C, in the original packaging.

[33], [34], [35],

Shelf life

Shelf life - up to 2 years. The prepared solution is not subject to storage and should be used immediately after preparation.

[36], [37], [38], [39]