C-Phlox

C-phlox is an antimicrobial drug that belongs to the group of fluoroquinolones. Let's look at the features of this drug, the indications for use, the dosage, possible side effects and storage rules.

[1]

Indications C-Phlox

Indications for use of C-phlox should be based on the symptomatology of the disease. Let's consider in what cases it is necessary to take C-Flox:

• Infectious and inflammatory diseases, which are caused by microorganisms sensitive to the action of C-phlox;
• Diseases of the abdominal cavity;
• Diseases of the respiratory tract;
• Diseases of bones and skin;
• Diseases of the pelvic organs;
• Septicemia;
• Treatment and prevention of postoperative infections;
• Treatment of infectious diseases in patients with a decreased immune system;
• Acute conjunctivitis;
• Bacterial ulcers of the cornea;
• Infectious lesions of the eyes, preoperative and postoperative prophylaxis in ophthalmic surgery.

[2], [3], [4]

Release form

The form of the drug C-phlox is a coated tablets and a solution for infusions in vials. Tablets are available in 0.25 g, 0.5 g and 0.75 g of active ingredient. Solution for infusion is issued in vials of 50 and 100 ml, and 1% solution of the drug in ampoules of 10 ml. In the carton of the drug contains one plate for 10 tablets, and in a box with injections - 10 bottles.

Two forms of release of C-phlox allow to choose the optimal and effective method of treatment. To prevent disease use C-Flox pills, but for emergency treatment - injections.

[5]

Pharmacodynamics

C-phlox is a broad-spectrum antimicrobial drug, it has a bactericidal effect. After ingestion, C-phlox suppresses DNA gyrase and produces inhibition of DNA synthesis of the bacterium. The preparation shows an effective action against gram-negative bacteria (Shigella spp., Escherichia coli, Neisseria meningitides and others).

The drug is active against Staphylococcus spp. And strains that produce penicillinase. The drug has an effect on some strains of Campylobacter spp., Mycoplasma spp., Enterococcus spp. The active substance of the drug - ciprofloxacin actively fights bacteria that produce beta-lactamases. The drug poorly inhibits the action of Clostridium difficile, Ureaplasma urealyticum and Nocardia asteroides. The effect of the drug on other bacteria and microorganisms is not sufficiently studied.

Pharmacodynamics C-phlox are the processes that occur with the drug after application. So, the active substance C-flox - ciprofloxacin has an effective bactericidal, that is, antibacterial action. The drug blocks DNA-gyrase, disrupts the division and growth of bacterial DNA and prevents DNA replication.

After administration, C-phlox causes morphological changes at the cellular level and leads to rapid death of bacterial cells. The active substance ciprofloxacin has a wide range of antimicrobial activities. C-phloex is active against:

• Enterococcus faecalis
• Staphylococcus (aureus, epidermidis, pneumoniae, pyogenes)
• Haemophilus influenzae, parainfluenzae
• Staphylococcus (haemolyticus, hominis, saprophyticus)
• Moraxella (Branhamella) catarrhalis
• Chlamydia trachomatis, as well as against other bacteria and microorganisms.

[6]

Pharmacokinetics

Pharmacokinetics of C-phlox are the processes of absorption, distribution, metabolism and excretion of the drug after its administration. Let's look at how the drug affects the body. After administration, C-phlox is completely absorbed by the gastrointestinal tract. Bioavailability of the drug is 70-80%. The maximum concentration of the drug in the blood is observed after 60 minutes after administration. Note that the drug must be taken before meals, as food slows the absorption process of the drug.

C-phlox is synthesized with plasma proteins by 30-40%. High concentration of the drug is observed in the kidneys, liver, genitalia, urine, lungs, bile, bone muscles, adipose tissue, cartilage and penetrates the placenta. The half-life of the drug with the use of tablets - up to five hours. Metabolized C-phlox in the liver, excreted with bile, forming low-activity metabolites.

[7], [8]

Dosing and administration

The method of administration and dose of the drug is administered individually and depends on the symptomatology of the disease, the age of the patient and other characteristics of the course of the disease and the state of the organism. On average, the period of treatment lasts from seven days to a month, the drug is taken twice a day for 250-750 mg. With the introduction of the drug use a single dose of 200-400 mg, the duration of treatment from one week or more. The drug is injected, but the preference is given to the dropwise administration within 30-50 minutes.

If the drug is used topically, then drop 1-2 drops into the conjunctival sac of the affected eye every 2-5 hours. After the improvement of the condition, the time interval between the procedures is increased.

[14], [15]

Use C-Phlox during pregnancy

Use of C-phlox during pregnancy is prohibited. The active substance of the drug ciprofloxacin penetrates the placental barrier and adversely affects the development of the fetus, causing pathology. Experimental studies have been conducted that have helped to establish that taking C-phlox during pregnancy causes arthropathy.

The drug excretes in breast milk, so it is forbidden to take it with breastfeeding. If you refuse to be treated during pregnancy is not possible, then C-flox is replaced by safer analogs.

Contraindications

Contraindications to the use of C-phlox are based on individual intolerance of the active components of the drug. So, you can not take the drug when:

• Epilepsy;
• Hypersensitivity to quinolones;
• During pregnancy and lactation;
• The drug is banned for adolescents and children who have not completed the formation of the skeleton, that is, up to 15 years;
• In case of impaired renal function.

C-phlox is contraindicated for use with drugs that reduce the acidity of the stomach, that is, antacids. Also, C-flox is contraindicated to use with alkaline waters, as this will lead to a decrease in the therapeutic effectiveness of C-phlox.

[9], [10], [11]

Side effects C-Phlox

Side effects of C-phlox appear when the dosage of the drug is not complied with and in the case of using a drug that has violated the rules of storage or shelf life. But sometimes, the side effects of C-phlox can also occur due to interaction with other drugs. Let's look at the most common side effects of C-phlox:

• Nausea and vomiting
• Disorders of vision and hallucinations
• Albuminuria
• Crystalluria
• Tachycardia
• Leukopenia
• Heart rhythm disturbances
• Neuropleenia
• Itchy skin
• Candidiasis
• Hives

With prolonged use of C-phlox, local side effects are possible. As a rule, they manifest as a painful condition, phlebitis, vasculitis, conjunctivitis.

[12], [13]

Overdose

Overdose C-phlox is possible with prolonged use of the drug, use of a high dose or improper intake. With an overdose, complications with kidneys occurred in patients who received the drug overdue. Therefore, when symptoms of an overdose appear, it is necessary to wash the stomach, take emetic and drink more liquid.

There are no other symptoms of overdose. But in some patients with cardiovascular diseases, it is possible to increase blood pressure and headaches.

Interactions with other drugs

Interaction of C-phlox with other drugs is possible only with the permission of the doctor. Thus, with the simultaneous use of the drug with didanosine, the absorption of C-phlox significantly decreases. This is due to the formation of complexons of the active substance C-phlox with magnesium buffers, which are contained in didanosine.

C-phlox is prohibited from taking concomitantly with warfarin, as the risk of bleeding increases. With the interaction of C-phlox with theophylline, the toxicity of the latter drug increases, which is dangerous for the human body. C-phlox poorly interacts with drugs that contain zinc, iron, magnesium or aluminum ions. Since such drugs reduce the absorption of C-phlox. That is why, in case of complex treatment, all medications should be taken at intervals, in order to avoid unwanted interactions.

[16], [17]

Storage conditions

The conditions of storage of C-phlox are described in the drug's instructions and must be fully observed. Since the shelf life of the C-phlox and its medicinal properties depends on the storage condition. The drug should be stored at room temperature, preferably in a place that is inaccessible to sunlight and children.

Storage conditions for diluted ampoules of the drug - no longer than 24 hours at a temperature of up to 10 degrees Celsius and 48 hours at a temperature of up to 5 degrees Celsius. If the storage rules are not observed, the drug loses its medicinal properties. In addition, due to non-observance of storage conditions, the physical properties of the preparation are violated. Powder, which is in vials, can change the color and consistency, this also applies to tablets.

Shelf life

Shelf life C-flox is indicated on the package with the drug and is 4 years, that is 48 months. At the expiration date of the drug, it must be disposed of. Take the drug is strictly prohibited, as this can lead to irreversible and unpredictable reactions of the body.