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Cernevit
Last reviewed: 03.07.2025

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Release form
The product is available in the form of a lyophilisate, which is used to create a solution for intravenous administration. It has the appearance of a loose, solid, yellowish-orange mass without an unpleasant odor.
The medicine contains the following active ingredients:
- Vitamin A (retinyl palmitate).
- Vitamin E.
- Vitamin D3 (Cholecalciferol).
- Vitamin C (ascorbic acid).
- Vitamin B1 (thiamine).
- Vitamin B2 (riboflavin).
- Vitamin B5 (pantothenic acid).
- Vitamin B6 (pyridoxine).
- Vitamin B12.
- Vitamin B9 (folic acid).
- Vitamin H (biotin).
The drug also additionally contains: glycine, soybean phosphatides, glycocholic acid, hydrochloric acid, sodium hydroxide.
Pharmacodynamics
Since this vitamin mixture is used during parenteral nutrition to improve the general condition of the patient's body, its pharmacodynamics are determined by the substances that are part of the drug.
Thanks to vitamin A, cell differentiation and growth are improved. Vision becomes clearer due to the improvement of its physiological mechanisms.
Processes associated with the exchange of phosphorus and calcium in the kidneys and bones are regulated in the body by vitamin D3.
Vitamin E is a popular antioxidant, so toxic products are not formed in the patient's body, which helps protect cell components.
Thiamine or vitamin B1 is involved in the formation of coenzymes, which, in turn, are associated with carbohydrate metabolism.
Riboflavin is one of the most important coenzymes in the human body. Vitamin B2 is associated with energy metabolism in cells, tissue respiration and macronutrient metabolism.
Vitamin B3 takes part in all reduction and oxidation processes, which are important in tissue respiration and macronutrient metabolism.
Pantothenic acid or vitamin B5 is closely associated with such processes in the body as gluconeogenesis, oxidative metabolism of carbohydrates, synthesis of fatty acids, steroid hormones, sterols, porphyrins.
Pyridoxine is considered an important coenzyme that is involved in the metabolism of carbohydrates, proteins and fats in the body.
Vitamin C is a very important antioxidant, without which the body does not form collagen and intercellular substance in sufficient quantities. Ascorbic acid also takes part in the synthesis of steroids and carnitine, in the biosynthesis of catecholamine, and in the metabolism of tyrosine and folic acid.
Vitamin B12 is of exogenous origin and is important in the process of myelin and nucleoprotein synthesis. It takes part in cell proliferation and is also necessary to maintain erythropoiesis and body development.
Biotin binds to four major enzymes and is involved in metabolism.
Folic acid is an important part of the process of normal erythropoiesis and nucleoprotein synthesis.
Pharmacokinetics
During parenteral nutrition, even lasting for many months, patients taking Cernevit have normal concentrations of all essential vitamins (B, A, D) in the plasma.
The pharmacokinetics of a drug is based on the substances that make up its composition.
Vitamin A is excreted through the kidneys and in bile, bound to proteins. Most of the vitamin D is concentrated in the kidneys and liver, excreted through the kidneys. Vitamin E enters the patient's blood with lipoproteins. There it can bind to albumin and is excreted through the kidneys.
Thiamine remains 90% in red blood cells and is excreted from the body through the kidneys. Riboflavin binds to proteins and can be excreted by the kidneys both as a metabolite and in an unbound form. In the human body, vitamin B3 is an amide or acid, and when it enters the blood, it is excreted mainly through the kidneys.
Pyridoxine is metabolized in the liver and excreted from the body via the kidneys. Pantothenic acid can be found in the body in two forms (unbound or as vitamin A). It is excreted from plasma and erythrocytes via the kidneys.
Vitamin B12 can be found in milk, and a large concentration of it accumulates in the liver. It can bind with proteins and is excreted through the kidneys. At normal concentrations, ascorbic acid is absorbed by the kidneys in full and can be excreted by the kidneys. Folic acid can accumulate in the liver, but is distributed equally throughout all tissues. It is excreted through the kidneys. Biotin can exist in plasma in a form that is bound to proteins or in a free form. It is excreted unchanged through the kidneys.
Dosing and administration
This mixture is used only for the preparation of a special solution that is administered intravenously. The standard dose during parenteral nutrition is one bottle once every 24 hours. The duration of therapy is determined by a specialist.
In a 5 ml vial, add 5 ml of water, 5% glucose solution or sodium chloride solution (0.9%) using a syringe. Stir slowly until all the lyophilisate is dissolved. The solution should be bright yellow or orange.
Administer intravenously over at least 10 minutes. It can be added to three- or two-component solutions if the substances are compatible with each other.
Observe aseptic conditions when administering.
Use Cernevit during pregnancy
To date, clinical studies on the use of Cernevit in the treatment of pregnant women have not been conducted. Therefore, the drug is not recommended for use during this period.
Since vitamins can be concentrated in breast milk and enter the child’s body through it, it is prohibited to use Cernevit during lactation.
Side effects Cernevit
Since this product is a mixture of vitamins, the only negative symptom when using it may be an allergy (itching, redness, hives, burning, swelling). If these unpleasant sensations appear, you should immediately stop taking the drug.
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Overdose
An overdose of Cernevit is possible mainly because it contains vitamin A. In this case, the patient may experience the following symptoms: headaches, stomach upset, increased intracranial pressure, swelling of the optic nerves, mental disorders, convulsions, emotional excitability, swelling of the skin, which is characterized by increased pain.
For treatment, the use of the drug is stopped and symptomatic therapy is carried out (the use of calcium is reduced, rehydration is carried out, diuresis is increased).
Interactions with other drugs
The drug contains the active substance vitamin B6 (pyridoxine), which is prohibited to take simultaneously with levodopa, as this can speed up metabolism. To prevent this interaction, in some cases, you can additionally take carbidopa.
The drug also contains folic acid, so it should be used with caution in combination with anti-epileptic drugs that contain primidone, phenobarbital or phenytoin.
Before using Cernevir, tell your doctor about all medications you have taken in the past.
Storage conditions
It is very important to store the medicine in a place that is inaccessible to small children. The air temperature should not exceed +25 degrees.
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Shelf life
The medicine can be used for two years after release. Do not take the medicine after the expiration date.
Attention!
To simplify the perception of information, this instruction for use of the drug "Cernevit" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.