Cereton

Nootropic drug, belongs to the group of cholinomimetics with a central mechanism of action. 

[1], [2], [3]

Indications of the cereton

It is used for therapy in patients who are in the recovery stage after severe craniocerebral trauma, ischemic or hemorrhagic stroke. Also used in the treatment of psycho-organic syndrome, senile pseudomelanchia, cognitive disorders.  

[4], [5]

Release form

This drug is produced in two forms: in the form of capsules and a solution that is used for injections. Oval capsules of gelatin have a slightly yellowish-brown color. Inside of them there is a transparent or translucent liquid of oily form.

The solution is used for the preparation of intramuscular and intravenous injections. It is completely transparent.

The drug contains an active component of choline alphosetate. Additional components that are included in the preparation are: purified water and glycerol.

Pharmacodynamics

Cereton is nootropic. Has a metabolic effect through the release of choline in the brain. Owing to choline, two important substances (phosphatidylcholine and acetylcholine) are synthesized, which are located in the neuronal membranes, and the metabolic processes that occur in the central nervous system are improved. On the other side of the brain, which was damaged, the blood flow is greatly increased. There is also an improvement in the spatial and temporal characteristics of bioelectric activity in the brain. The consciousness of the patient is restored, the behavioral and cognitive reactions of the patient are improved.

It features a corrective and preventive effect on the involutionary psychoorganic syndrome, reducing the cholinergic activity of neurons and changing the amount of phospholipids in the composition of their membranes. Participates in the synthesis of phospholipid membranes, thereby improving the synaptic transmission, as well as their plasticity. 

Pharmacokinetics

Absorption of the drug is 88%. Through the GEB penetrates quite simply. If taken orally, the concentration of choline in the brain is 45%. Accumulation of the drug occurs in the lungs, brain and liver.

Lungs excrete 85% of the drug in the form of carbon dioxide, 15% of the drug is excreted through the intestines and kidneys.

Use of the cereton during pregnancy

Pregnant women, as well as those who feed the baby with breast milk, use of this drug is strictly prohibited.

Contraindications

The agent "Tsereton" can not be used for such diseases and symptoms:

1. When a patient is in an acute stage of a hemorrhagic stroke.
2. Intolerance of the components of the drug.
3. The patient's age is up to eighteen years.
4. Pregnant women and women who are breast-feeding children.

Side effects of the cereton

1. Nausea, there may be vomiting. For treatment it is necessary to reduce the dosage of the drug.
2. Allergies (rash, itching, burning).

[6], [7], [8]

Dosing and administration

If the drug is used for prevention or recovery after traumatic brain injury, hemorrhagic or ischemic stroke, then the dosage is as follows: 800 mg of the drug in the morning, 400 mg of the drug in the daytime. Duration - six months.

In other diseases, "Tsereton" is used 400 mg three times per 24 hours. Best after eating. The duration of therapy is from three to six months.

[9], [10], [11]

Overdose

When an overdose of this drug in the patient there is a very strong nausea, which must be treated with symptomatic therapy.

Interactions with other drugs

Significant interaction with other drugs has not been identified.

[12], [13], [14], [15], [16]

Storage conditions

This tool is included in list B, it is recommended to store it in a place that is inaccessible to young children. It is important that the place is completely protected from direct sunlight. The air temperature should not exceed +25 degrees. 

[17]

Shelf life

Is three years old. Can not be used after the expiration of this period.

[18]