Caduet 10/10

Kaduet 10/10 is a complex medicinal product, due to the main components of which it is widely used in cardiological practice.

The composition of the drug includes two components that can affect the heart and blood vessels. So, one active component - amlodipine, is a blocker of calcium channels. As a result of its activity, an expansion of the blood vessels is observed, which leads to a decrease in blood pressure.

The second active component of Kaduet is represented by atorvastatin, the direction of which is the inhibition of enzymes that participate in the formation of cholesterol. As a result of taking atorvastatin, a decrease in the amount of cholesterol, the formation of atherosclerotic plaques and, accordingly, an increase in the lumen of the blood vessel.

The code of the automatic telephone exchange indicates the belonging of the medicinal product to preparations that are capable of affecting the lipid profile and the level of arterial pressure.

Kaduet 10/10 is widely used both in cardiology and other fields of medicine. Its use is very convenient, since one tablet contains two essential medicines. Thus, lowering blood pressure and reducing cholesterol in the blood, which is one of the factors in the development of hypertension.

Indications Caduet 10/10

The drug Cadet is used in cardiac practice to treat hypertension if it is characterized by three or more risk factors for the development of complications such as angina pectoris, arrhythmia, myocardial infarction, stroke, or transient ischemic attack.

Indications for application Kaduet 10/10 include the need to share several drugs from the group of hypocholesterolemic and antihypertensive drugs.

It is necessary to consider the possibility of using additional medications, if using Kaduet can not achieve the desired result for the level of cholesterol and blood pressure.

Indications for use Kaduet 10/10 take into account the presence of a combined pathological condition, which is caused by excessive excess of cholesterol. As a consequence, the risk of atherosclerotic plaque formation increases, which gradually narrow the internal lumen of the blood vessel.

Thus, as more and more plaques appear, there is an increase in intravascular resistance. The heart needs to push blood through the narrowed lumen, which requires more strength.

As a result, the blood pressure rises, which requires medical support. Combined drug Caduet acts simultaneously in two directions: lowers cholesterol and normalizes blood pressure.

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Release form

The caduette has a tabletted form of release, so that the drug is easy to dose, since each tablet has a certain amount of amlodipine and atorvastatin. Observing dosages can avoid the occurrence of adverse reactions and the effects of an overdose.

The main active components of the drug are amlodipine and atorvastatin. Tablet Kaduet 10/10 contains 10 mg of amlodipine, a calcium channel blocker, which, by relaxing the muscle layer of the vessels, dilates them and lowers blood pressure.

The second active ingredient is atorvastatin, the dose of which in one tablet is 10 mg. Due to its ability to inhibit the activity of enzymes, a decrease in the amount of cholesterol in the bloodstream is observed.

Form of release Kaduet allows you to individually choose the dosage, taking into account the severity of hypertension, the level of cholesterol and the presence of concomitant pathology.

In addition to the main components, it is necessary to note the presence of additional ones, such as silicon dioxide (anhydrous coloidal), starch, calcium carbonate, hydroxypropylcellulose and others.

The form of the release is a film-coated tablet. The main physicochemical features of the tablet drug are white coat shade, oval shape, presence of Pfizer on the surface and "CDT" and "051" (drug code) on the other.

The drug is available in cardboard packages, in which there are 3 blisters of 10 tablets.

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Pharmacodynamics

Combined drug is characterized by a double direction in the mechanism of action, which provides pharmacodynamics Kaduet 10/10.

Due to the fact that the drug has two main active substances in its composition, it is therefore necessary to separately consider their effect on the human body.

The first component is amlodipine. The mechanism of its influence is based on the ability to block the channels through which calcium flows, so that the muscle fibers can not contract. Thus, the wall of the blood vessel relaxes, and the inner diameter increases.

The action of amlodipine is due to its belonging to the group of medications, called slow calcium channel blockers.

The second component is atorvastatin. It is able to inhibit the activity of HMG-CoA reductase. Being a strong selective inhibitor of the enzyme, the main feature of which is the ability to take part in the conversion of 3-hydroxy-3-methylglutaryl coenzyme A into a melatonite. The latter is considered a precursor of sterols, one of which is cholesterol.

Pharmacodynamics Kaduet 10/10 causes the same mechanism of action of amlodipine and atorvastatin both in the composition of Kaduet, and as a monotherapy. Thus, taking one tablet of the drug, there is a double action aimed at reducing the amount of cholesterol and lowering blood pressure.

Pharmacokinetics

The drug has a complex composition, as a result of which the mechanism of action of each component must be considered separately. Pharmacokinetics Kaduet 10/10 is based on the activity of amlodipine and atorvastatin.

After oral administration of the drug in the therapeutic dosage, the maximum concentration of amlodipine in the bloodstream appears after 6-12 hours. Bioavailability is in the range of 64-80%. The distribution volume is approximately 21 l / kg. In addition, it should be noted that the bioavailability of amlodipine, food intake can not have a braking or stimulating effect.

 After in vitro studies, conclusions were drawn, in the bloodstream of a person with arterial hypertension, the drug is 97.5% transported by blood in a bound state with plasma proteins.

About 90% of the dose of amlodipine is metabolized in the liver, after which metabolites appear in the inactive state. Excretion of the drug is provided in two stages: the kidneys yield up to 10% amlodipine and about 60% of its metabolites. After a week of regular intake of the drug in the plasma, its stable concentration is observed.

 Pharmacokinetics Kaduet 10/10 from the side of atorvastatin causes the appearance of a peak concentration in the blood in 1-2 hours after a single dose of the drug. The suction process depends directly on the dose of atorvastatin taken. Bioavailability (its absolute level) is at the level of 12%, and systemic - 30%.

Systemic bioavailability depends on the functioning of the digestive system (stomach, intestine, liver), so it can be at a low level. Absorption of the drug is impeded by food intake, slowing it down.

Regardless of this, the process of reducing cholesterol occurs in full, despite the intake of food. Approximately 95% of the drug circulates through the circulatory system in a bound state with plasma proteins.

The process of excretion of atorvastine and its metabolites is carried out by the liver, mainly with bile. Only about 2% of the drug is excreted by the kidneys.

Dosing and administration

The preparation has a tablet form of release, used for oral use. After a thorough examination, the doctor should prescribe a certain dosage of the drug. It is advisable to start with a dose of 5-10 Kaduet, which corresponds to 5 mg of amlodipine and 10 mg of atorvastatin.

However, in the case of high blood pressure values, the way of application and dose can be changed. So, it is possible to increase the dose to the 1st tablet Kaduet 10/10 once a day. Medication can be taken regardless of food and time of day.

This dosage assumes 10 mg of amlodipine and 10 mg of atorvastatin. When choosing a dosage, it is necessary to control blood pressure and stop at the minimum active dose of the drug.

During the therapeutic course it is recommended to periodically check the level of cholesterol in the blood to correct the dosage. If blood pressure indicators do not reach the desired parameters, then the use of additional drugs is allowed, except for drugs from the group of calcium channel blockers.

The same applies to the level of cholesterol in the blood. If he is on the background of admission Kaduet remains at high values, it is allowed to combine the drug with the drugs of the statin group to reduce cholesterol.

Kaduet is not allowed to be used with fibrates, as well as people with severe form of hepatic and renal insufficiency.

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Use Caduet 10/10 during pregnancy

The process of growth and development of the fetus requires certain expenditure of strength and nutrients from the body of the pregnant woman. To complete the formation of organs and systems of the fetus, vitamins, biological active substances, microelements and many other things are necessary.

One of the main components is cholesterol with its derivatives. However, taking into account the mechanism of action of atorvastatin, which consists in inhibition of HMG-CoA reductase and lowering of cholesterol level, it must be remembered that this can become a threat to the fetus.

Women, who were appointed by Caduet for life, should use methods of contraception to avoid the development of pregnancy. As soon as conception occurs, the drug should be withdrawn.

Using Kaduet 10/10 during pregnancy is not allowed, in view of the fact that the harm to the fetus in many ways exceeds the benefit for the woman.

With regard to the period of lactation, the intake of Kaduet is also not desirable, since the ability of atorvastatin to penetrate breast milk has been proven, which can become a toxic factor for the baby. Information about amlodipine and its penetration into milk is absent, therefore it is impossible to estimate the ratio of benefit to a woman and harm to a child.

Contraindications

Most drugs have their contraindications, which must be read before using them. Contraindications to use Kaduet 10/10 must be known in order to avoid the appearance of adverse reactions that threaten human health.

Thus, it is necessary to refuse taking Cadet in the presence of hypersensitivity to the medicines of the dehydropyridine group, atorvastatin and amlodipine, as well as additional components in their composition.

In addition, contraindications include a severe form of hepatic pathology, an elevated level of transaminases that exceeds the upper limit of the norm by a factor of 3.

With regard to the joint administration of drugs, then Kaduet can not be used simultaneously with ketoconazole, telithromycin and itraconazole.

Also, contraindications to the use of Kaduet 10/10 include the third degree of arterial hypertension, shock states of various origin, unstable hemodynamics, obstruction of the aortic lumen, and the presence of unstable angina due to myocardial infarction.

During the treatment course, you need to regularly examine the level of liver enzymes, comparing the dynamics with the initial indicators recorded before taking Kaduet.

With care, it is necessary to apply the drug to people who abuse alcohol, as well as with a history of severe liver disease.

Atorvastatin has an effect on skeletal musculature, provoking the appearance of pain syndrome, myositis and myopathy. During the treatment course the drug does not need to constantly examine the level of CKK, but in people who are predisposed to acute necrosis of muscle tissue and in the presence of muscle symptoms, the quantitative composition of CKF should still be monitored.

Side effects Caduet 10/10

The influence of Cadet was investigated with the help of people suffering from hypertension and hypercholesterolemia for several months. One group of people took Cadet, and the other - a placebo.

As a result, the most common side effects of Kaduet 10/10 were identified. So, from the side of the nervous system, there were dizziness, weakness, drowsiness and pain in the parietal and occipital areas.

The digestive tract in some people reacted to the drug premature dyspepsia, nausea and pain in the abdomen. In addition, it is possible to increase the volume of the joint due to swelling of its tissues, as well as an increase in liver enzymes and CK.

Rarely allergic manifestations occur, blood glucose levels decrease, weight increases, insomnia, depression, ringing in the ears and skin sensitivity change.

Among the rare side reactions, it is worth highlighting the change in the cellular composition of the blood from the appearance of leukopenia, thrombocytopenia, and cardiovascular disorders in the form of rapid heartbeat, fainting, myocardial infarction and changes in rhythm and conduction of the nerve impulse along the myocardium.

Very rare side effects of Kaduet 10/10 are violations of the act of breathing, the appearance of clinical symptoms of rhinitis, pharyngitis, bronchitis. Also sometimes there is a reaction to the drug in the form of intestinal dysfunction (constipation, diarrhea) and various disorders of the digestive and excretory systems.

Overdose

Thanks to the tablet form of the drug, Cadet is very simple in dosing, as a result of which overdose is extremely rare. The drug is well tolerated if a certain dosage and frequency of administration are observed.

In case of taking a large dose of medication, excessive expansion of the blood vessels is possible, as a result of which the blood pressure decreases. This action is due to the ability of amlodipine to block the flow of calcium and prevent the reduction (spasm) of the vessels.

Depending on how much the blood pressure has decreased, it is necessary to monitor the condition of a person by examining the work of the heart. To increase pressure, vasoconstrictors are used - drugs, narrowing vessels. However, you must strictly monitor their dosage to avoid excessive pressure build-up.

In order to accelerate the process of removing amlodipine from the bloodstream and reduce its concentration, one can use dialysis, which will reduce the therapeutic effect of the drug.

With regard to an overdose of atorvastatin, it requires symptomatic treatment, since there is no specific antidote, and dialysis is not effective in this case. Of particular importance is the control of the liver, examining its enzymes and CK.

Interactions with other drugs

Kaduet in combination with other medicines can provoke the development of undesirable side reactions. Therefore, before using it, it is recommended to learn the interaction of Kaduet 10/10 with other drugs in order to avoid deterioration of health.

It is forbidden to use Cadula with fibrates, in particular with gemfibrozil and intravenous administration of dantrolene.

Due to the fact that the drug contains atorvastatin, there is a possibility of developing an acute form of necrosis of muscle fibers and myopathy. This condition is due to its belonging to the group of hypocholesterolemic drugs.

This is especially true with the simultaneous use of Kaduet with other drugs that can increase the concentration of atorvastatin in the blood and enhance its therapeutic effect.

These drugs include immunosuppressors, in particular cyclosporine, antibacterial agents - macrolides (clarithromycin, azithromycin), azole antimycotic medications (nefazodone, intraconazole and ketoconazole), high doses of niacin, gemfmbrosil and other fibrolic acid derivatives and HIV protease inhibitors.

Interaction Caduce 10/10 with other drugs, for example, fusidic acid is prohibited because of their pharmacokinetic incompatibility. In the case where it is impossible to avoid its use, the use of atorvastatin should be discontinued.

Amlodipine should be taken with caution in combination with baclofen. Simultaneous reception with anticonvulsants, alpha-1-blocker, imipramine antidepressants, beta-blocker, amifostine, sildenafil and hormonal agents.

With atorvastatin should be used carefully inhibitors of cytochrome P450 3A4, protease inhibitors, fusidic acid, niacin, warfarin, hormonal contraceptives, phenazone, diltiazem, colestipol and grapefruit juice.

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Storage conditions

In order to maintain the therapeutic properties of the drug should follow certain recommendations, in particular, the storage conditions Kaduet 10/10.

Supporting the recommended temperature regime, humidity and light levels, the drug retains its therapeutic effectiveness during the shelf life. The given term is established by the manufacturer after the carried out researches.

Storage conditions of Kaduet 10/10 suggest maintaining a temperature of no higher than 30 degrees in the room where the medicine will be located. In addition, special attention should be paid to sunlight, the direct rays of which should not fall on the packaging with Kaduet.

If the recommended conditions are not observed, the risk of drug loss by its structure increases, as a result of which the pharmacokinetic and pharmacodynamic properties of the preparation change.

Do not forget about kids who at any time can get medication and try. In this case, the development of an overdose and symptoms of poisoning. To avoid this, it is recommended that you keep the medicine away from children.

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Shelf life

In order for a person to be aware of the duration of the drug's preservation, it is necessary for the manufacturer to indicate the expiration date on the external packaging of the drug. This will help to quickly find the date.

In addition, on each blister should also indicate the date of production and the last application, as the outer packaging can be lost, and the expiration date is a mandatory and very important information.

Thus, in the implementation of recommendations on the storage conditions of the drug for a certain period of time, the drug retains its medicinal properties and does not cause harm.

The expiry date of the Cadet is 3 years, after which the drug is banned for use in order to avoid the development of undesirable consequences that threaten human life.