Kalanchoe juice

Kalanchoe juice is squeezed from the fresh leaves of the plant (pinnate Kalanchoe - Kalancho pinnata), as well as its upper grassy division. Due to their natural origin, preparations based on Kalanchoe juice have an anti-inflammatory effect, accelerate the processes of purification from necrotic masses and epithelization of the wound surface, including ulcerative lesions.

The natural components of the drug very rarely cause allergic reactions of the skin or mucous membranes to take the medicine.

Kalanchoe juice is used as an external medicine for sanitation of the focus, activation of the formation of granulation tissues and restoration of the protective cover.

The spectrum of application of the drug is wide enough, as its therapeutic properties help in many areas of medicine - in surgical, gynecological and dental practice. In particular, in dentistry, Kalanchoe is used to reduce swelling of inflamed tissues, stagnant phenomena and pain in the gums and teeth. In addition, the drug accelerates the healing process after the opening of abscesses and other surgical manipulations.

According to the international classification, the medicinal product belongs to the group of medicines that are used in dermatology for the treatment of ulcerative lesions and wounds of various origins. 

Kalanchoe juice has found wide application in many fields of medicine, which facilitated the process of recovery of patients of dermatological, surgical, dental and many other departments. With its help, the process of cleaning the wound surface from necrotic tissues, pus is accelerated, the intensity of inflammation decreases, and the repair of damaged skin or mucous membrane occurs much faster.

[1], [2]

Indications of the kalanchoe Juice

With a curative purpose, Kalanchoe juice is used as a basic or additional remedy in surgery, dentistry, dermatology and other fields of medicine.

Indications for the use of Kalanchoe juice in surgical practice are the treatment of wounds with purulent masses and skin lesions that persist for a long time do not heal, as well as ulceration of the shin as a result of circulatory disorders in the lower extremities (varicose veins).

The drug has proven effective in the treatment of pressure sores, burns, and in combination with other agents is used to prepare the wound for stitches and skin grafting.

Indications for use Kalanchoe juice in dentistry is represented by gingivitis (acute common catarrhal, subacute or chronic form of hypertrophic catarrhal), inflammatory-dystrophic stages of periodontal disease of 2-3 degrees. In addition, Kalanchoe helps with chronic aphthous stomatitis with frequent relapses.

In the process of delivery, damage to the perineum is possible, including ruptures that do not heal for a long time and bring uncomfortable sensations. In this case, the drug helps to speed up healing. In addition, during the postpartum period, breastfeeding may cause nipple cracks, which are also amenable to recovery with the help of Kalanchoe juice.

In gynecological practice, the drug is effective in erosive lesions of the cervical mucosa and inflammation of the cervical canal.

[3], [4]

Release form

Kalanchoe juice comes in the form of a transparent liquid, the color of which varies from yellow to orange, slightly opalescent. Consistency is uniform, but sometimes you can look through a fine suspension that dissolves easily when shaken. The aroma of the medicine is quite specific, and the taste is bitterish-sweet. The auxiliary is chloroform.

The form of release is presented by several complete sets. So, the juice can be produced in ampoules, the volume of which is 3 ml, 5 ml or 10 ml. If the liquid is contained in the vial, then its vial may be 20 ml or 100 ml.

There is also an ointment with Kalanchoe juice, which contains 40 g juice, furozolidone 250 mg, anhydrous lanolin 60 g and novocaine 250 mg. Ointment is available in tubes or cans of 10 g, 20 g and 50 g.

The form of juice production determines the content of organic acids in terms of malic acid at least 1.2%, and therefore in 1 liter of the drug there are about 996.6 ml of juice of fresh calanchoe sprouts.

Due to this form, the drug is conveniently used for external application in the form of applications, irrigation of the wound surface and application of drops on the affected area.

[5]

Pharmacodynamics

Due to the natural origin of the medicinal product, all natural substances entering into its composition determine the mild therapeutic effect of the drug.

The Kalanchoe juice rarely causes irritation on the skin or mucous membranes, and almost does not cause allergic reactions. With the help of flavonoids, tannins, enzymes, organic acids and trace elements, the intensity of the inflammatory process in the lesion site decreases.

Pharmacodynamics Kalanchoe juice provides stimulation of the regenerative capabilities of the body. By activating the growth and differentiation of tissue cells, a gradual increase in granulation is observed, which fill the tissue defect.

As the use of Kalanchoe is marked recovery of the surface protective layer of skin or mucous membranes, which prevents the entry of infectious agents in deep-lying layers.

The healing process is also accelerated by the antiseptic property of the drug. The inflammatory process decreases more rapidly when purulent masses or necrotic tissues are removed from the lesion site.

[6], [7]

Pharmacokinetics

The natural composition of the drug means the presence of such components as flavonoids, tannins in a small volume, trace elements, in particular magnesium, copper, iron and aluminum, as well as enzymes, ascorbic and organic acids.

The Kalanchoe juice is extracted from fresh plant sprouts. Natural components have an anti-inflammatory effect by reducing the output of inflammatory mediators to the lesion focus from the bloodstream.

Due to the narrowing of the vessels and a decrease in the permeability of their membranes, the liquid part of the blood is retained in the bloodstream without leaving the tissue. Thus, the puffiness and, accordingly, the pressure on the nerve endings decreases, which reduces the intensity of the pain syndrome.

Pharmacokinetics Kalanchoe juice in addition to anti-inflammatory effect has antiseptic and regenerative effect. The healing process occurs more quickly, as there is regular cleaning of the wound surface from purulent deposits and necrotic tissues, which contribute to the connection of a hundredfold infection.

[8], [9]

Dosing and administration

Depending on the medical field of use of the medicine, as well as the place of the pathological focus, it is necessary to distinguish between the way of application and the dose of the drug.

So, in surgical practice, Kalanchoe is used for the purpose of carrying out a toilet of skin around the lesion (wound or ulcer defect). To do this, use a syringe and a thin needle to irrigate the surface with medicinal solution.

After washing it is recommended to cover with a gauze bandage of 4-5 layers, which can also be moistened with the drug. In the beginning, when purulent masses and necrotic tissues are present, the dressing should be changed every day.

As the wound surface is cleansed, the bandage can be changed every other day, depending on the therapeutic dynamics. In order to easily remove the gauze bandage after 24 hours, it must be moistened with a 3% hydrogen peroxide solution.

In addition to changing the bandage during the day, it is necessary to additionally irrigate the lower layers of gauze 2 times in order to completely impregnate the wound with the drug.

In the presence of a purulent discharge it is necessary to use the Kalanchoe juice for a week, in parallel, which should be followed by a course of antibacterial therapy. Then continue washing before 3 more weeks.

In midwifery practice, it is recommended that when nipple cracks appear, 1 drop should be applied to each nipple after feeding the baby. The treatment course is 4-5 days. Before applying the baby to the breast, you must first clean the nipple from the remnants of the medicine (if any). In addition, in the presence of ruptures and wounds in the perineal region, you should use the Kalanchoe juice in the same way as in surgery.

The method of application and dose in dental practice are selected individually, taking into account the severity of the pathological process and the presence of concomitant diseases.

Usually the drug is used in the form of applications by wetting the juice with a gauze dressing from several layers. Before using the calanchoe, it is recommended to sanitize the oral cavity. For the application, the drug should be heated to 37 degrees in a water bath.

Gadgets can be applied up to 4 times a day for up to 20 minutes during a week or two. A special effect is worth noting with the joint application of the Kalanchoe juice and physiotherapy procedures.

[15], [16], [17], [18],

Use of the kalanchoe Juice during pregnancy

The process of laying and forming organs in the fetus occurs in the first trimester of pregnancy, then their intensive growth and development is observed. By the end of pregnancy, the fetus's organism is formed in such a way that it can exist independently outside of the mother and later continues its development.

Throughout the period of pregnancy, any negative factor, including medications, can have a fatal effect on the fetus. As a result, there may be failures in the formation of organs and systems, which clinically will be manifested by their inadequate functioning after childbirth.

The use of Kalanchoe juice during pregnancy is not permitted due to the lack of data on the effect of the drug on the fetus and the course of pregnancy in general. Studies on the effects of drugs on the process of bearing a fetus are difficult, since there is a huge danger of the development of side effects in both the pregnant and fetal body.

After giving birth during the breastfeeding period, the woman can lubricate the calanchoe juice with a prophylactic purpose in order to avoid the formation of cracks, as well as with the healing one, even if they are present. Before applying and the last application of the medicine on the nipple should take at least 3-4 hours. In addition, it is necessary to rinse the remnants of the drug from the nipple even if visually it is not visible.

Contraindications

Each person genetically in the body has immune responses to the administration of certain medicines. Some may not have intolerance to drugs, and others suffer from allergic reactions after taking certain medications.

Contraindications to the use of Kalanchoe juice means the presence of individual characteristics of the body, when a person does not fit this drug, the introduction of which develops a violent response.

The most frequent clinical manifestations are dizziness, headache, severe weakness, nausea, vomiting, abdominal pain and lack of air.

In view of the fact that Kalanchoe is used for external exposure, it is worth highlighting the possible occurrence of an allergic reaction from the skin or mucous membranes.

So, the area on which the medicinal product was applied can turn red, slightly become large in volume due to puffiness, and also there are feelings of burning or tingling.

Contraindications to the use of Kalanchoe juice also include the use of the drug in childhood and internal medication, which can cause poisoning.

[10], [11]

Side effects of the kalanchoe Juice

The reaction of the body to the administration of the drug is its individual tolerability. Side effects of medications may show minor clinical symptoms, and can cause serious allergic reactions, for example, anaphylactic shock or Quincke's edema.

Side effects of Kalanchoe juice can cause burning sensations in the place of application of the drug. If in addition to it there is no redness or swelling, then next time it will be necessary to pre-dilute the drug with 1-2% solution of novocaine. The ratio of components should be 1: 1, but provided that there is no allergic reaction to novocaine.

However, if after a single or multiple applications tingling and burning sensations appear, the site becomes more hyperemic and swollen, then it is worth to cancel the drug and consider using analogues.

Side effects of Kalanchoe juice usually appear very rarely, but if they were seen, then it is necessary to act symptomatically.

[12], [13], [14]

Overdose

Based on the rules for the use of the drug and following the recommendations on dosages and the frequency of administration, an overdose of Kalanchoe juice is very rare.

Thus, there may be an increase in the manifestations of adverse reactions or the appearance of new clinical symptoms. Overdose can develop after using a large amount of medicine for one application or not for several days.

Overdose may manifest as symptoms of an allergic reaction. On the skin integuments or mucous membranes, where a medicinal preparation has been used, there may appear a hotbed of hyperemia, swelling and even a burning sensation, tingling or itching.

If the dose was so high that a large amount of medicines fell into the bloodstream, then the likelihood of developing a general allergic response of the body increases.

Among the clinical manifestations is dizziness, headache, weakness, abdominal pain, but the most dangerous is the swelling of the upper respiratory tract, which threatens asphyxia.

[19], [20], [21]

Interactions with other drugs

Due to the fact that the components and active substances of the juice are not able to penetrate the bloodstream to the extent that it has any significant effect, therefore its use in parallel with other systemic medicines is allowed.

In general, there is a favorable interaction of Kalanchoe juice with other antibacterial drugs, as in most cases it is necessary to take antibiotics to fight the infection, not only in the lesion but also in the bloodstream.

With regard to medicinal products of local use, it is necessary to take into account their interaction with each other. To avoid the development of adverse reactions or undesirable symptoms due to their joint application, a certain time interval must be observed.

It is necessary for the first applied preparation to be able to fully act and stay in the minimum concentration. After this, you can use the following drug. This interval should be at least 4 hours.

[22], [23], [24],

Storage conditions

To maintain the therapeutic properties of the drug, it is necessary to follow certain recommendations for its storage. For this purpose, the optimum temperature regime, humidity and light level should be maintained.

So, the storage conditions of Kalanchoe juice suggest the content of the medicine in a place where the temperature level will not exceed 8 degrees, but it will not fall below 2 degrees. Such a temperature regime allows to preserve the structure of the Kalanchoe juice in the necessary location, which will not change its medicinal properties.

In addition, direct sunlight on the medicinal product is not allowed, since it also threatens the medicinal properties of the medication.

One of the mandatory conditions of storage is the lack of access of children to the Kalanchoe juice. If the drug is kept in ampoules, babies can get injured. In addition, they can taste it, which will lead to poisoning.

If the drug gets on the mucous membranes or skin, and the baby has a tendency to allergies, it is possible to develop an allergic reaction.

[25], [26], [27], [28]

Shelf life

The storage conditions of the medicinal product must be observed throughout the life of the drug. The date of manufacture and last use should be indicated on the outer packaging of the medicine, and if possible on each vial and ampoule.

This is necessary to inform the person about the expiration date during which he can apply the medicine. The expiration date implies the preservation of all the medicinal properties of the medication specified in the instructions.

As soon as the last period for use expires, the drug is categorically not allowed to be used in any form. The shelf life of the Kalanchoe juice is 2 years, after which the preparation is not suitable for use.

[29]