Bioparox

Bioparox is a topical antibiotic used for diseases affecting the throat. Contains the component fusafungine, which has anti-inflammatory activity.

When used in vitro, the fusafungin element demonstrates an antibacterial effect, which suggests the potential for developing an in vivo effect against group A streptococci, mycoplasma pneumoniae, staphylococci with pneumococci, candida albicans, certain strains of neisseria and some anaerobes. [ 1 ]

Indications Bioparox

It is used for antibacterial and anti-inflammatory therapy in case of active stages of inflammation in the upper respiratory tract.

Release form

The drug is released in the form of a nasal spray, inside aluminum containers equipped with a main nozzle and a dosing valve; the container volume is 10 ml.

Pharmacokinetics

After administration of fusafungine, it accumulates mainly in the nasal and oropharyngeal mucosa. A small amount of fusafungine is temporarily detected in blood plasma (minimum detectable volume is 1 ng/ml), but this does not affect the safety parameters of the drug.

Dosing and administration

The medication is used in a dosage of 4 injections (orally) or 2 injections into each nostril (nasally). The procedure is performed 4 times a day. If there is no improvement after 7 days of therapy, it is necessary to consider the option of selecting an alternative treatment.

Bioparox is used orally and nasally; a special nozzle included with the drug is used. The nozzle must be disinfected once a day - wiped with cotton wool previously soaked in a 90% ethanol solution.

• Application for children

The medicine should not be used by persons under 12 years of age.

Use Bioparox during pregnancy

During pregnancy, the medication is used with extreme caution. There is no clinical information regarding the use of Bioparox in pregnant women.

There is no information on whether fusafungine is excreted in human milk. The question of whether to continue or discontinue breastfeeding or treatment should be decided taking into account the benefits to the mother and any possible risks to the infant.

Animal testing has shown no direct or indirect adverse effects on pregnancy, parturition, fetal development, or the postnatal period. In addition, no effects on fertility were observed in male or female rats.

No studies have been conducted in animal studies to determine whether fusafungine is excreted in breast milk.

Contraindications

Main contraindications:

• severe intolerance to the active element of the drug or other auxiliary components;
• the presence of a tendency to develop bronchial spasms and allergies.

Side effects Bioparox

Side effects include:

• immune disorders: development of anaphylaxis is observed in isolated cases;
• problems with the function of the nervous system: dysgeusia is often observed;
• visual disturbances: hyperemia often develops, affecting the mucous membrane of the eye;
• lesions in the area of the mediastinum with the sternum and the respiratory tract: sneezing often occurs. Coughing, dryness in the throat or nose, and a sore throat are also quite common. Dyspnea, laryngospasm, swelling of the larynx, bronchial spasm and asthma occur sporadically;
• digestive disorders: nausea is often observed. Vomiting may also develop (information obtained from post-registration studies);
• disorders associated with the epidermis and subcutaneous tissues: urticaria, itching, Quincke's edema and rash develop occasionally.

Overdose

There is only limited information regarding fusafungine poisoning.

In case of overdose, circulatory disorders, dizziness, numbness of the oral cavity, as well as increased burning and pain inside the throat occur.

It is necessary to perform symptomatic actions and monitor the patient's condition.

Storage conditions

Bioparox should be stored away from objects that produce intense heat and should not be exposed to temperatures exceeding 50°C. Burning the container is prohibited, even if the medicine is completely used. In addition, the drug should be kept in a place closed to small children. The container with the medicine should not be sealed.

Shelf life

Bioparox can be used within a 2-year period from the date of production of the therapeutic substance.

Analogues

An analogue of the drug is Grammidin.

Reviews

Bioparox receives quite mixed reviews from patients. It is stated that the drug demonstrates high efficiency in the treatment of diseases, but at the same time has a large number of disadvantages - this is the high cost, and the unpleasant taste of the drug, and the presence of many rather dangerous side effects.