Bactockweave

Bactoklave is an antibacterial medicinal product that helps cure a number of infectious diseases. Let's consider the main indications for the use of the drug, its pharmacological action, the way of application and dosage.

The active substance Bactoclav - amoxicillin three hydrates, potassium clavulanate, magnesium stearate, sodium starch and other constituent components. Drug form of the drug - tablets. Pharmacotherapeutic group Bactoklav - antibacterial agents.

Indications Bactockweave

The main indications for use Bactoklav - is the treatment of infectious diseases. Bactocklave is used for bacterial infections that are caused by microorganisms that are sensitive to the drug. The drug helps in the treatment of infections of the lower respiratory tract (lung abscess, pneumonia, bronchitis). Sinusitis, otitis media, tonsillitis and other infections of the ENT organs, are also treated with this drug.

Bactocklave helps in the treatment of infections of the genitourinary system and pelvic organs (cystitis, prostatitis, bacterial vaginitis, gonorrhea, postpartum sepsis, septic abortion and other diseases). Infections and lesions of soft tissues, secondarily infected dermatoses and wound infections are treated with Bactoklav. The drug is used to treat postoperative infections and as a prophylaxis for surgical infectious lesions.

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Release form

Form of release Bactoclav - coated tablets. One tablet contains 875 mg of amoxicillin in the form of trihydrate and 125 mg of clavulanic acid in the form of potassium clavulanate. The drug is available in cardboard packages, in one package can be a blister on three or ten Bactoklav tablets.

This form of release of the drug allows you to calculate the intake of tablets for the entire course of treatment. Tablets should be taken before meals to ensure maximum absorption of the active ingredients of the drug.

Pharmacodynamics

Pharmacodynamics Baktoklav is the processes that occur with the drug in the body after it is taken. The active substance Bactoclav - amoxicillin, refers to semi-synthetic antibiotics with a wide spectrum of action directed at the destruction of gram-negative and positive bacteria. The drug disintegrates under the action of beta-lactamases, so Bactocklave does not affect the microorganisms that synthesize the enzyme.

The bacterocidal bactericidal action on such microorganisms as:

• Gram-positive aerobes - Corynebacterium, Staphylococcus aureus, Bacillus anthracis and others.
• Gram-positive anaerobes - Peptococcus, Clostridium.
• Coagulase-negative staphylococci are Streptococcus agalactiae, Streptococcus viridans, Staphylococcus epidermidis.
• Gram-negative aerobes - Gardnerella vaginalis, Neisseria gonorrhoeae, Brucella, Shigella and others.
• Gram-negative anaerobes - Fusobacterium, Bacteroides.
• And also such microorganisms as: Leptospira icterohaemorrhagiae, Chlamydia, Treponema pallidum and others.

Pharmacokinetics

Pharmacokinetics Bactoklave is the process of absorption, distribution, metabolism and excretion of the drug. After ingestion, the Bactocklave is absorbed in the gastrointestinal tract, it is recommended to take the drug before meals. The connection with proteins is kept at the level of 20% (amoxicillin), and the clavulanic acid bond is 20-30%. Both active substances are metabolized in the liver.

Bactoklav is excreted with the help of the kidneys 8 hours after admission. The drug is excreted in urine and feces, about 20% of the Bactactus is unchanged. In diseases of the kidneys and liver, the drug is excreted and metabolized much more slowly. It is also possible the manifestation of side effects Bactoklave.

Dosing and administration

The method of administration and dose of Bactoclav are prescribed by the attending physician and depend on the disease that is to be treated. With regard to general recommendations for the treatment of infections of mild and moderate severity, Bactoclav is recommended to take one tablet twice a day, both for children and adults. In severe infectious lesions and recurrent infections, the drug is prescribed to take two tablets three times a day.

With special care, the Bactoklave dosage is chosen for patients who undergo an adrenal cleansing of the blood, ie hemodialysis, no more than one tablet per day. In case of violations of the liver and chronic renal failure, liver function monitoring is performed. If Bactoclave is taken by elderly patients, the dose of antibacterial drug is corrected depending on the function of the kidneys. The period of treatment with the drug should not exceed 14 days, since symptoms of overdose and side effects of Bactoclav are possible.

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Use Bactockweave during pregnancy

Use Bactoklav during pregnancy is not recommended, as is the administration of any medications. During pregnancy, the Bactocklave is prescribed only for medical reasons, when the potential benefit to the mother is more important than the risk for the normal development of the baby.

Medical research was conducted, in which pregnant women took part. Future mothers took Bactoklav, in 10% of the subjects, the drug was used to cause necrotizing enterocolitis in a child. Also, the use of Bactocklave during pregnancy can lead to premature rupture of the membranes.

Contraindications

Contraindications to the use of Bactocklave are based on individual intolerance of the active substances of the drug. Bactoclave is not recommended for infectious mononucleosis, korepodobnoy rash and phenylketonuria. The drug is contraindicated in patients with impaired hepatic functions and jaundice episodes due to the use of one of the active substances of the drug (amoxicillin, clavulanic acid) in the anamnesis.

With special care the drug is prescribed during pregnancy and lactation, with diseases of the gastrointestinal tract, kidney failure and colitis. Bactocklave is allowed for use only on medical instructions. It is contraindicated to take the drug on its own, as only the doctor can choose the necessary dosage of the medicine that will help cure the infectious disease.

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Side effects Bactockweave

Side effects of Bactoclav are manifested due to individual intolerance of the active components of the drug, due to improper dosing and for a number of other reasons. The main symptoms of an overdose affect the functioning of the digestive system. Taking medication can cause nausea, diarrhea, vomiting, stomatitis, darkening of tooth enamel and exacerbation of chronic gastritis. In some patients, side effects of Bactoclav manifest in the form of thrombocytosis, leukopenia or hemolytic anemia.

The drug can cause headaches, dizziness, increased anxiety. Side effect of the drug may affect the allergic reaction to the skin, cause hives, dermatitis or allergic vasculitis. Less common side effects of Bactoclav are manifested in the form of candidiasis, hematuria, or interstitial nephritis.

Overdose

Overdose Bactocklave may occur due to prolonged use of antibacterial agent, non-compliance with the rules and conditions for storage of the drug or because of increased sensitivity to active components. Overdosing manifests itself in violations of water-electrolyte balance in the body and painful symptoms from the gastrointestinal tract. Overdose Bactoclav involves symptomatic treatment. With severe overdose symptoms, hemodialysis is used to excrete the active ingredients of the drug, which cleanses the blood from the Bacto-Clav components.

To avoid overdose symptoms, it is not recommended to take the drug on your own. The vaccine should be prescribed by the attending physician, indicating the dosage and duration of treatment. When symptoms of overdose, from the use of the drug is recommended to refuse or temporarily stop taking.

Interactions with other drugs

Interaction Bactoklave with other drugs is possible only on medical advice and doctor's permission. So, if the drug is taken concomitantly with ascorbic acid, then the level of absorption of the antibacterial agent is increased, and if with laxatives or antacids, the absorption is significantly reduced. Interaction Bactoklave with bacteriostatic drugs produces an antagonistic effect.

If the drug interacts with anticoagulants, then the intestinal microflora is suppressed, the prothrombin index and the synthesis of some vitamins decrease. With such an interaction, it is necessary to monitor the level of coagulation of the blood. Diuretics and phenylbutazone, when taken concomitantly with Bactoclav, increase the concentration of the active substance of the drug, that is, amoxicillin. When interacting with allopurinol, allergic reactions to the skin are possible.

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Storage conditions

Storage conditions Bactocklave complies with the norms and rules for storage of any other antibacterial agents and tablets. According to the instructions, the drug should be stored in a dry, cool place, which is inaccessible to children and away from sunlight. Bactoklave tablets of white color, have an oval form and a shell with a fault line on one side.

If the storage conditions of Bactoclav are not respected, the drug loses not only its medicinal properties, but also its appearance. Tablets can change the color from white to yellowish and even brown. This can happen due to non-compliance with the temperature regime or the expiration of the expiration date. In this case, the drug must be disposed of, and it is strictly forbidden to take it.

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Shelf life

Shelf life Bactocklave is 24 months from the date of manufacture of the antibacterial agent, which is indicated on the package of the preparation. Please note that the drug is only available on prescription. That is, you can take Bactoklav only for medical reasons and medical permission. It is strictly forbidden to take Bactoklav after the expiry date, as there may be the emergence of side uncontrolled and even irreversible reactions of the body.