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Advantan
Last reviewed: 23.04.2024
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Advantan is part of a group of hormonal drugs, corticosteroids, intended for external use in dermatology. Manufacturer - pharmaceutical company Bayer AG (Germany). Another trade name for the drug is Sterocort.
[1]
Indications Advantan
The use of Advantan is indicated for neurodermatitis; atopic, allergic and photodermatitis; with dyshidrosis, degenerative, seborrhoeic and microbial eczema in adults and children; at a psoriasis: at a simple deprive.
[2]
Pharmacodynamics
The active active substance of this drug is a synthetic analogue of the hormone of the adrenal cortex, a non-halogenated methylprednisolone steroid, aceponate.
Methylprednisolone aceponate has lipophilic molecules and penetrates through the lipid membrane of skin cells. When interacting with the protein receptors of the cytoplasm by hydrolysis, 6α-methylprednisolone-17-propionate forms, which enters the cell nucleus and acts as a stimulant for the synthesis of intracellular polypeptides, which in turn inhibit the release of arachidonic acid necessary for the formation of prostaglandins and leukotrienes, inflammatory mediators .
In addition, there is a temporary decrease in the activity of tissue macrophages, fibroblasts, keratinocytes and lymphocytes, which leads to blockade of the release of interleukins - specific mediators of the immune system.
Thus, Advantan removes local inflammation and irritation in the form of itchy rashes, redness and caused by increased proliferation of lichenification cells (thickening of the epidermis).
Pharmacokinetics
After application to the skin in places of inflammation and rashes, Advantan penetrates through the upper layers of the skin, where it is in sufficiently high concentrations for 24 hours. The active substance of the drug manifests its activity only in the foci of inflammation, no more than 2.5% of 6α-methylprednisolone-17-propionate enters the systemic bloodstream. Its inactivation occurs by binding to glucuronic acid in the blood plasma.
Advantan does not accumulate in the body and after 30-32 hours it is completely excreted in the urine.
[8],
Dosing and administration
Advantan in the form of an ointment or emulsion should be applied to the skin (lightly rubbing) once a day. The standard duration of therapy for adults is 1.5 months, for children - no more than 4 weeks. The drug is not recommended to apply to large areas of the skin. Avoid contact with eyes.
[10]
Use Advantan during pregnancy
Strictly contraindicated use of Advantan during pregnancy and during lactation.
Contraindications
The following contraindications apply to the use of Advantan:
- hypersensitivity to the drug and its components;
- lupus;
- syphilitic eruptions;
- rashes in infectious diseases (chicken pox, rubella, measles, etc.);
- shingles;
- herpes;
- perioral dermatitis;
- rosacea;
- skin reactions to vaccination.
[9]
Side effects Advantan
Possible side effects of the drug: redness of the skin at the site of application, itching or burning of the skin, blistering (vesiculosis) rash. Prolonged use of Anvantan can cause atrophy of the skin, enlargement of small vessels of the skin, the appearance of acne, inflammation of hair bulbs (folliculitis), excessive hair growth (hypertrichosis), and rashes in the mouth (perioral dermatitis).
Storage conditions
Cream, ointment and emulsion should be stored at a temperature not higher than 24-25 ° C, the maximum permissible temperature for storing the drug in the form of a greasy ointment + 28-30 ° C.
[15]
Shelf life
The shelf life of the cream, ointment and emulsion is 3 years, oily ointment - 5 years.
[16],
Attention!
To simplify the perception of information, this instruction for use of the drug "Advantan" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.