Advantan

Advantan is a member of a group of hormonal drugs-corticosteroids intended for external use in dermatology. The manufacturer is the pharmaceutical company Bayer AG (Germany). Another trade name of the drug is Sterocort.

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Indications Advantan

Advantan is indicated for neurodermatitis; atopic, allergic and photodermatitis; dyshidrosis, degenerative, seborrheic and microbial eczema in adults and children; psoriasis: lichen simplex.

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Release form

Advantan is available in the form of a 0.1% fatty ointment (in tubes of 5 and 15 g), in the form of a 0.1% cream (in tubes of 5 and 15 g), and also in the form of a 0.1% emulsion (in tubes of 10, 20 and 50 g).

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Pharmacodynamics

The active ingredient of this drug is a synthetic analogue of the adrenal cortex hormone, the non-halogenated steroid methylprednisolone aceponate.

Methylprednisolone aceponate has lipophilic molecules and penetrates the lipid membrane of skin cells. When interacting with protein receptors of the cytoplasm, 6α-methylprednisolone-17-propionate is formed by hydrolysis, which enters the cell nucleus and acts as a stimulator of the synthesis of intracellular polypeptides, which, in turn, inhibit the release of arachidonic acid, which is necessary for the formation of prostaglandins and leukotrienes - inflammation mediators.

In addition, there is a temporary decrease in the activity of tissue macrophages, fibroblasts, keratinocytes and lymphocytes, which leads to a blockade of the release of interleukins - specific mediators of the immune system.

Thus, Advantan relieves local inflammation and irritation in the form of itchy rashes, redness and lichenification (thickening of areas of the epidermis) caused by increased cell proliferation.

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Pharmacokinetics

After application to the skin in areas of inflammation and rashes, Advantan penetrates through the upper layers of the skin, where it is present in fairly high concentrations for 24 hours. The active substance of the drug is active only in areas of inflammation, and no more than 2.5% of 6α-methylprednisolone-17-propionate enters the systemic bloodstream. It is inactivated by binding to glucuronic acid in the blood plasma.

Advantan does not accumulate in the body and is completely excreted in the urine after 30-32 hours.

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Dosing and administration

Advantan in the form of an ointment or emulsion should be applied to the skin (rubbing in lightly) once a day. The standard duration of therapy for adults is 1.5 months, for children - no more than 4 weeks. The drug is not recommended for application to large areas of skin. Avoid contact with eyes.

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Use Advantan during pregnancy

The use of Advantan during pregnancy and lactation is strictly contraindicated.

Contraindications

There are the following contraindications for the use of Advantan:

• hypersensitivity to the drug and its components;
• lupus;
• syphilitic rash;
• rashes in infectious diseases (chickenpox, rubella, measles, etc.);
• shingles;
• herpes;
• perioral dermatitis;
• rosacea;
• skin reactions to vaccination.

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Side effects Advantan

Possible side effects of the drug: redness of the skin at the site of application, itching or burning of the skin, vesicular rash. Long-term use of Anvantan can cause skin atrophy, dilation of small blood vessels in the skin, acne, inflammation of the hair follicles (folliculitis), excessive hair growth (hypertrichosis), and rashes in the mouth area (perioral dermatitis).

Overdose

Overdose of the drug during long-term use is excluded.

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Interactions with other drugs

There is no information regarding the interaction of Advantan with other drugs.

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Storage conditions

The cream, ointment and emulsion should be stored at a temperature no higher than +24-25°C, the maximum permissible temperature for storing the drug in the form of a fatty ointment is +28-30°C.

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Shelf life

The shelf life of the cream, ointment and emulsion is 3 years, and the shelf life of the fatty ointment is 5 years.

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