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Adenorm
Last reviewed: 03.07.2025

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Adenorm is a drug from the group of selective blockers of adrenergic receptors of the α-1D and α-1A types.
Indications Adenorm
The drug is used in the treatment of benign prostatic hyperplasia.
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Release form
The drug is available in capsule form. One blister contains 10 capsules; one cardboard package contains 3 blisters with capsules.
Pharmacodynamics
The active substance of the drug is tamsulosin hydrochloride, which blocks postsynaptic adrenergic receptors of the α-1D and α-1A groups, located in the smooth muscles of the prostate, the neck of the bladder, and the prostatic region of the urethra. Under the influence of the drug, the smooth muscles relax, the functioning of the detrusor improves, and the manifestations of irritation and obstruction that occur as a result of benign prostatic hyperplasia disappear. Adenorm does not cause systemic changes in blood pressure, even in those patients who suffer from hypertension. This drug achieves its maximum therapeutic effect 2 weeks after the start of therapy.
Pharmacokinetics
After internal administration, tamsulosin is rapidly absorbed in the gastrointestinal tract. The active component reaches its maximum saturation in the blood plasma 6 hours after a single dose. The drug has high plasma protein binding rates (up to 99%). Tamsulosin is metabolized in the liver. In the process, metabolites are formed that have a weaker pharmacological effect.
After a single use, the half-life is 10 hours. If the drug is taken regularly, the half-life of the active substance increases to 13 hours. The drug is excreted through the kidneys, most often as metabolites. A maximum of 10% of the substance is excreted unchanged.
Dosing and administration
The medicine is intended for internal use. The capsule should not be chewed or crushed - it should be swallowed whole, washed down with plain water. The use of the drug is not associated with meals.
The duration of the treatment course, as well as the dosage, are prescribed to patients individually - this should be done by the attending physician. For adults, the dose is usually 1 capsule 1 time per day.
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Contraindications
Among the contraindications:
- High individual sensitivity to individual components of the drug;
- Patients undergoing therapy due to severe liver dysfunction, as well as patients with a history of orthostatic collapse.
Adenorm should be prescribed with special caution to people with renal dysfunction (patients with a creatinine clearance rate of less than 10 ml/minute).
Side effects Adenorm
In general, the drug is tolerated by patients without complications, but in some cases, the following side effects were observed as a result of its use:
- Cardiovascular system: heart rhythm disturbances, fainting, orthostatic collapse;
- CNS organs: muscle weakness, headaches;
- Allergy: itching and rash on the skin, as well as hives.
Overdose
In case of drug overdose, patients experienced a decrease in blood pressure, as well as the appearance of compensatory tachycardia.
Interactions with other drugs
In combination with medications from the category of α1-adrenergic receptor blockers, it can cause a decrease in blood pressure.
When Adenorm and cimetidine are taken together, there is a slight increase in the saturation index of tamsulosin in the blood plasma.
During the interaction of the drug with furosemide, a slight decrease in the saturation of the active element in the plasma is observed.
When Adenorm is combined with warfarin and diclofenac, the half-life of tamsulosin is reduced.
Storage conditions
The medicine must be kept in a dry place, protected from sunlight. The air temperature should be within 15-25 °C.
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Shelf life
Adenorm can be used for 2 years from the date of manufacture of the medicine.
Attention!
To simplify the perception of information, this instruction for use of the drug "Adenorm" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.