Abacavir Sulfate

As a rule, Abacavir sulfate is prescribed to people who are carriers of HIV infection. Thanks to him, you can fight back the virus. This drug is antiviral. Apply it in the composition with antiretroviral combination therapy. In isolation, it will not give any positive dynamics. Abacavir sulfate has a powerful effect on the virus contained in the human body.

[1]

Indications Abacavir Sulfate

Apply it in the treatment of HIV infection only in conjunction with other drugs and under the supervision of a doctor.

[2], [3], [4]

Release form

The form of release of the drug is standard. The drug is a tablet that is pre-coated with a film sheath. This at times improves the patency of the drug. Typically, each tablet contains 300 mg of the components that fight the virus. There is no other form of output. Only tablets covered with a special coating. Their composition includes only Abakavira sulfate. In one package can contain both 20 and 50 tablets.

[5]

Pharmacodynamics

This drug is often referred to a class of nucleotide inhibitors that possess reverse transcriptase. He is rightfully considered a powerful inhibitor of both HIV-1 and HIV-2. The work of the drug is that it leads to the breakdown of the most powerful RNA chain. Due to this, the virus replication cycle stops. It is also unlikely that the same cross-resistance will develop. Initial therapy of Abacavir sulfate is ineffective, because it is caused by a mutation of one of the components of M184V. The active component significantly reduces the level of RNA. If you use it with other drugs, it can prevent neurological complications. In addition, it is able to slow the development of resistance.

[6]

Pharmacokinetics

After the drug is taken internally, it can quickly absorb. As a rule, in adults, bio-tolerance is 83%. If you take the drug twice a day for one tablet, then the maximum and minimum concentrations will not exceed 30% and 99%. It is necessary to understand, the food can significantly slow down the absorption of the drug, but it does not affect the AUC at all. Abacavir sulfate is perfectly capable of penetrating into the cerebrospinal fluid. If it is used exclusively in therapeutic doses, then it binds to a fairly moderate degree with human plasma proteins. This suggests that the use of the drug together with other drugs will not lead to their displacement. As for the metabolism, Abacavir sulfate is metabolized mainly in the liver. And it is derived quite simply. As a rule, this process takes no more than 1.5 hours. Even if a person has problems with the liver, some of its functions are violated, then this does not affect metabolism. Of course, the process may slow down a little, but this is not critical. If there are interruptions in the work of the kidneys, then again, everything is displayed in a timely manner. Therefore, it is not necessary to adjust the dosage to people who have irregularities in the work of this body. The pharmacokinetics for patients over 65 years of age have not been studied.

[7], [8], [9]

Dosing and administration

It is necessary to understand that only a doctor who has experience working with HIV-infected people can prescribe this medication. Abacavir sulfate can be used both before meals and after. According to some recommendations, the tablet should be swallowed whole. If a person is not able to do this, then it is crushed. It is possible to apply the drug in the form of a solution. As for the course of treatment, it is assigned only by the attending physician. Adults are recommended to take 2 tablets daily. But, only if its dosage is 300 mg. If it is 600 mg, then one tablet will suffice. Patients who have problems with the kidneys, namely with some of their functions, can use the drug without making a special dosage. If there are problems with the liver, it is advisable to apply the medicine in the form of a solution.

[14], [15]

Use Abacavir Sulfate during pregnancy

Future mothers to take this medicine is strictly prohibited. Abacavir sulfate can adversely affect the development of the fetus. Especially if pregnancy is at an early stage. In this case, you should contact your doctor for advice. It is likely that he will find an analogue of the drug that will not bear such negative consequences. In addition to influencing the fetus, the medicine can also harm the future mother. Therefore, with the use of the drug is desirable to wait.

Contraindications

People who have an increased hypersensitivity to the drug, you can not take it. In this case we are talking about its auxiliary substances. In case of renal failure, treatment with the drug is also prohibited. Abacavir sulfate negatively affects the child's age in a similar way can be said about teenagers as well. Therefore, before age 18, it is strictly prohibited. Contraindications include pregnancy and lactation. There is a special risk in people who have terminal stage of renal failure. In this case, do not even try to apply the drug. The reaction of the body can be unpredictable.

[10], [11]

Side effects Abacavir Sulfate

Often, patients experience headache, retardation of reactions, fast fatigue and apathy. Naturally, all this can be accompanied by nausea, vomiting, rash, cough, fever and respiratory failure. In rare cases, pancreatitis worsens, peripheral edema, conjunctivitis and even anaphylactic reactions appear. In rare cases, erythema, myalgia, as well as hepatic or renal failure can develop. There was information that some people had various kinds of inflammation. But only in those cases when Abakavira sulfate was taken in conjunction with other drugs.

[12], [13]

Overdose

No information was given about the overdose. And in general, to talk about any specific signs or symptoms is meaningless. But such an opinion was formed on the basis that no data had been received. Nevertheless, it is necessary to monitor the dose of the drug consumed. After all, otherwise there may be signs of intoxication. In this case it is necessary to conduct therapy, which is able to support a person in a standard way. Therefore, it is still necessary to exercise some caution. After all, if no cases of overdose have been found before, this does not mean that in the future this can not happen. Abacavir sulfate is a very specific drug.

[16], [17]

Interactions with other drugs

Together with complex therapy, the drug is used freely. In the course of clinical studies, it has been established that nothing dangerous can happen when using this medication with others. Ethanol is able to slow the metabolism of Abacavir sulfate. True, the clinical significance of this does not change much. But what is most interesting, the drug itself does not affect the metabolism of ethanol in any way. As for retinoids, they are able to be excreted from the body and at the same time interact well with Abacavir sulfate. No special studies have been conducted.

[18]

Storage conditions

Like any other pre -part of Abacavir, the sulfate has its own storage features. So, drugs do not like direct sunlight. That's why you should avoid them hitting. In this case, it is recommended to store the drug in a dark place, but it is important that there is no dampness there. The medicine does not like cold and high humidity. But the maximum storage temperature is 30 degrees Celsius. Naturally, the main and main condition is inaccessibility for children. This is an important criterion for storing not only this drug, but all the others.

[19], [20], [21],

Shelf life

The shelf life directly depends on many features of the drug. So, if it comes to tablets, then they can be applied for 5 years. A similar situation with the solution of Abacavir sulfate. But there is one more important criterion in this case. So, if we talk separately about tablets, then after opening a new package, you can use them all for the same 5 years. Naturally, if the medicine has not lost its appearance. Simply put, you should observe the appearance of the package itself. As for the solution, the open vial can not be stored for such an amount of time. In this case, everything depends on the place where the medicine is located. Usually the shelf life does not exceed a day. This indicator should be monitored. In general, Abacavir sulfate is not able to quickly deteriorate.

[22], [23]