5-NOC.

5-NOC is a broad-spectrum antimicrobial drug from the oxyquinoline group. It generally has a bacteriostatic effect on a large number of microorganisms that usually cause inflammation of the urinary tract. The latter include E. coli, mycoplasma, ureaplasma, candida, staphylococcus, dermatophytes.

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Indications 5-NOC.

This drug is prescribed to everyone without exception, both men and women. Indications for the use of 5-NOC can be completely different. The following diseases and conditions are the reason for its use: treatment of cystitis, prostatitis. Suitable for the treatment of urethritis, epidimitis, pyelonephritis, which are usually caused by microorganisms and are sensitive to nitroxoline.

It can be used to prevent infectious complications after all sorts of surgical manipulations and operations. In addition, this drug is used to prevent relapses, namely in the chronic form of the disease, as well as in some infectious diseases of the genitourinary system. The drug is actively used to prevent the development of all sorts of infections after instrumental studies have been carried out, which include cystoscopy and catheterization.

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Release form

The number of grams in tablets is 50 mg, which are covered with a smooth shell. It can be most often orange. Tablets are usually round, biconvex and shiny. They are stored in plastic or polyvinyl bottles in cardboard packaging, the number of which is 50 pcs.

The dosage of the drug varies for both adults and children. It is worth remembering that treatment with 5-NOC is prescribed by a qualified doctor. The duration of therapy may vary depending on the specific disease.

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Pharmacodynamics

5-NOC is a medical preparation that has a fairly wide range of action. The medicine differentially reduces the synthesis of bacterial DNA. It can be active against gram-positive bacteria. It is highly effective against the following types of fungi: all kinds of Candida, dermatophytes, mold fungi, and some pathogens of mycosis.

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Pharmacokinetics

The nitroxoline it contains is absorbed from the gastrointestinal tract. The maximum concentration in plasma can reach the required effect 1.5-2 hours after the tablet is taken orally.

When using this drug, an increased concentration of conjugated and unconjugated drug in the urine is noted. Metabolized in the liver. It is excreted by the kidneys in the same form and partially with bile.

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Dosing and administration

The doctor recommends taking the drug 5-NOC during meals, as well as after a person has eaten. The tablets are swallowed whole. There is no need to chew them and then wash them down with the required amount of liquid.

The period of the treatment course and the dose of the medicine can only be prescribed by the attending physician, who will individually establish the necessary and beneficial treatment for each patient’s health.

Adults should generally take 100-200 mg several times a day, or 4 to be precise. The course of treatment and its duration, if a person takes it constantly, should not exceed 1 month. The drug can be taken in whole courses. But in this case, they are taken orally for 14 days. After this, it is important to take a break of 2 weeks, after which the intake is resumed again. Treatment with this drug according to the established scheme can last about several months.

The dose for children and adolescents (from 1 year to 14 years) is usually 50-100 mg. They need to be taken in this amount 4 times within 24 hours. If the drug is used continuously, the duration of treatment can be 1 month. If the doctor prescribes courses, it can take several months.

The daily dose for children aged 2 months to 1 year is calculated at 25 mg/kg of body weight per day. After that, it is important to divide the calculated dose into 4 doses. The course should not be prolonged. It is useful from 10 to 3 weeks. In case of severe infections, the duration of treatment can be extended to 1 month.

To prevent infectious diseases after operations and diagnostic procedures, adults are usually prescribed 100 mg of the drug 4 times a day for a duration of no more than 2-3 weeks.

If patients have impaired renal function, then most often 50% of the dose recommended for patients with normal renal function is prescribed. Patients who have renal failure or a moderate degree are prescribed half the usual daily dose of the drug.

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Use 5-NOC. during pregnancy

Pregnancy is a dangerous time for taking any medications. And if, in addition, the instructions do not contain information about the use of the drug during pregnancy, then it is better to refuse it. The drug is especially contraindicated for use during lactation. When prescribed by a doctor during lactation, it is recommended to temporarily suspend breastfeeding. But this can only be in extreme cases. Under other circumstances during pregnancy, it should not be taken by expectant mothers. Otherwise, it can affect not only the nursing mother, but also the future baby. So using 5-NOC during pregnancy is not recommended.

Contraindications

Doctors consider increased individual sensitivity to some components of the drug and derivatives of 8-oxyquinolines to be contraindications to the use of 5-NOC. It should not be taken in the following cases:

• cataracts;
• during pregnancy and lactation;
• 5-NOC should not be administered to patients who have been diagnosed with liver or kidney dysfunction.
• For children under three years of age, the drug should only be prescribed in the most extreme cases, if no other medications have worked.

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Side effects 5-NOC.

If patients use this drug for a period of time, they may develop side effects of 5-NOC. These include:

The gastrointestinal tract and liver can cause nausea, vomiting, anorexia in humans. The general condition may cease to be normal due to some liver dysfunctions.

There may be tachycardia. From the nervous system, a person may have a headache, dizziness may begin. Coordination of movement may be impaired, polyneuropathy and paresthesia may suddenly begin. If the drug is used for more than one month, this may cause the development of optic neuritis. Allergies can also become side effects of 5-NOC. It can cause skin rash, itching, urticaria. Other unpleasant consequences include staining of urine in a bright yellow color. Also thrombocytopenia and an increase in the content of uric acid in the blood.

All side effects that occur when using the drug 5-NOC are quite short-lived and usually disappear when the drug is discontinued.

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Overdose

Having reviewed all the data on the drug 5-NOC, no data on overdose of this drug has been received yet.

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Interactions with other drugs

If this drug is taken simultaneously with other oxyquinoline derivatives, the risk of developing all sorts of toxic reactions becomes much higher. Therefore, it is not recommended to prescribe it together with other drugs. Nitroxoline should not be used simultaneously with other drugs, especially those containing hydroxyquinolines or their derivatives. If the drug is prescribed to patients who have impaired renal function due to cumulation of nitroxoline, then medical supervision is absolutely necessary. Interactions of 5-NOC with other drugs can be dangerous. There is no need to prescribe courses of treatment longer than a month without having an additional diagnosis of liver and kidney function.

Undoubtedly useful information that patients do not always notice when taking medications is that if you are prescribed two or more drugs, they can either weaken or enhance the effectiveness of each other. In the first case, you may not get the desired result from the drug, and in the second, you can poison your body.

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Storage conditions

It is better to store the preparation in a dry place where water cannot penetrate. It is desirable that direct sunlight does not fall on the preparation. It is good when the storage temperature does not exceed 25ºС. It is also advisable to hide it in a place inaccessible to children.

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Special instructions

5-NOC is a drug of the oxyquinoline group, which has antibacterial, antiprotozoal and antifungal effects. The drug consists of the active substance, nitroxoline, which is a synthetic compound, a derivative of 8-oxyquinoline. The drug selectively promotes the suppression of DNA synthesis in the cells of microorganisms, which can prevent their normal reproduction. Nitroxoline also allows the formation of necessary compounds with nucleic acids and metals, enzymes of the cell membrane of microorganisms. 5-NOC helps reduce the synthesis of respiratory enzymes and membrane proteins. It is capable of disrupting oxidation-reduction processes in bacterial cells. Nitroxoline is famous for its bactericidal and bacteriostatic action on a large number of microorganisms.

The properties of 5-NOC are able to prevent the formation of DNA in the pathogen cell. In addition, the drug includes complexes that contain microbial cell enzymes, which include metal ions.

Each tablet contains 50 mg of nitroxoline and other excipients.

Nitroxoline, which is in the drug, is an active element against such bacteria as: staphylococci, streptococci, corynebacteria, klebsiella, proteus, shigella, salmonella, neisseria, mycoplasma, ureaplasma, some other types of fungi and other microorganisms.

The drug is completely absorbed in the gastrointestinal tract and after a couple of hours it reaches its maximum concentration in the blood. 5-NOC is excreted from the body as a result of kidney function and is partially excreted by the liver with bile.

It is worth mentioning once again the benefits that a person receives when using the drug 5-NOC. Among many diseases of infectious origin, urinary tract infections are far from the last place. These include pyelonephritis, urethritis, cystitis. Women especially suffer from these diseases, which most often occurs as a result of their anatomical and physiological characteristics of the urinary tract. Among men, the most common urinary tract infections include: epididymitis, prostatitis, urethritis. Developmental anomalies can also lead to impaired urine flow and increased inflammation.

Today, pharmacies are famous for their numerous drugs that are intended to treat this group of diseases. Many of these auxiliary agents include antibiotics with many undesirable side effects that usually lead to disruption of normal microflora. The drug 5-NOC is a uroseptic that suppresses the synthesis of microbial cell DNA and does not lead to dysbacteriosis.

5-NOC is used for absolutely any inflammation, which, as a rule, is caused not only by bacterial microflora, but also by simple intracellular organisms and fungi. The drug is also useful for prevention before or after medical manipulations, which include cystoscopy, urethroscopy, TUR, as well as at the beginning and after the end of operations on the urinary system. 5-NOC can be used starting from childhood, or more precisely from three years. Contraindications for use include severe renal and hepatic dysfunction. It is also best to refrain from using it during pregnancy and breastfeeding. The dosage form in the form of 50 mg tablets has an undoubted advantage over injections of antibiotics and uroseptics and makes it possible to take 5-NOC in any situation.

Allergic and other reactions to 5-NOC are not so numerous, and if they do occur, then quite rarely. They can be avoided if you take the drug during meals. Another advantage of the drug: it can be used for a long period of time, which is especially important for recurring kidney and bladder infections. Therefore, the drug 5-NOC is one of the most popular drugs for the treatment of all kinds of adverse urinary tract infections.

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Shelf life

The drug is available only by prescription and the shelf life of 5-NOC is 5 years.

Always remember that expired medications should be thrown away and not continued. Otherwise, they will not help and may even cause great harm.

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