Barol

Barol is a blocker of the proton pump used in diseases of the digestive tract. Consider the indications for its use, dosage, adverse reactions and therapeutic effect. The drug is part of the pharmacological group of drugs used in diseases of the digestive tract for the treatment of ulcers of the duodenum and stomach. Its action is based on a decrease in the level of production of saline acid in the gastrointestinal tract.

Indications Barol

Barol is prescribed for such diseases:

• Symptomatic ulcer or erosive gastroesophageal reflux disease.
• Zollinger-Ellison syndrome.
• An active ulcer of the duodenum (peptic).
• Active ulcer of the stomach (benign).
• Supportive and symptomatic treatment of gastroesophageal reflux disease.
• Combination therapy with antibacterial drugs for the eradication of Helicobacter pylori with peptic ulcer of the duodenum or stomach.

Indications for use are based on the pharmacological properties of the medication. Before the start of therapy, it is very important to exclude any malignant neoplasms. If it is prescribed for patients with severe impairment of liver and kidney function, then medical supervision is required in the early stages of treatment.

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Release form

The drug is available in capsules with an enteric-soluble coat of 10 and 20 mg of rabeprazole sodium. This form of release simplifies the treatment process, since it allows you to calculate the necessary dosage for the entire course.

The active substance is rabeprazole sodium. Auxiliary ingredients: magnesium carbonate, nipromellose, neutral pellets, titanium dioxide, sodium hydroxide, talc, magnesium carbonate, methacrylic acid copolymer, macrogol, iron oxide red / black.

Pharmacodynamics

The active component of the drug refers to antisecretory compounds, that is, chemically replaced by benzimidazole. Pharmacodynamics indicates anticholinergic properties. Rabeprazole sodium is not an antagonist of histamine H2 receptors. The substance inhibits the secretion of gastric acid acid by specific inhibition of the enzyme H + / K + -ATPase of parietal cells of the stomach. This type of enzyme system refers to proton pumps, as it blocks the final stage of acid production. The component is transformed into the active sulfanamide form and reacts with the cysteine of the proton pump.

Antisecretory activity occurs one hour after taking a single dose and reaches its maximum values in 2-4 hours. The suppression of the basal function and the stimulation by the food of acid secretion occurs one day after the administration of the first dose and lasts for 48 hours. The effectiveness of the medication is enhanced by the daily use of the prescribed dosage. But stable oppression of secretion occurs 3 days after the start of treatment. After completion of therapy, the secretory activity is restored within 2-3 days.

The drug affects the concentration of gastrin in the blood serum. With the regular use of tablets for 12 months, the concentration of gastrin increases and inhibits the secretion of acid. After cessation of treatment, the level of gastrin returns to the initial for 10-14 days.

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Pharmacokinetics

The processes of absorption, distribution, metabolism and excretion of a drug are its pharmacokinetics. With their help you can find out how quickly the therapeutic effect comes and how the drug behaves after getting into the body.

• Absorption - after ingestion, the capsules pass the stomach and dissolve in the intestine. Rabeprazole is rapidly absorbed, its maximum concentration in the blood plasma begins in 3.5 hours. Bioavailability is 52% and does not increase with repeated use. Eating does not affect absorption.
• Distribution and metabolism - the degree of binding to blood plasma proteins 97%. Metabolized by the kidneys in the form of several metabolites: thioester, carboxylic acid, dimethylthio-olefm, conjugate of mercapturic acid and other secondary metabolites.

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Dosing and administration

To achieve the desired result of treatment, for each patient the physician selects the method of administration and the dose of Barol:

• Active benign gastric ulcer and peptic ulcer of the duodenum - 20 mg once a day or 10 mg 2 times a day. The course of treatment is 4 weeks.
• Erosive, ulcerative form of gastroesophageal reflux disease - 20 mg once a day or 10 mg 2 times a day for 4-8 weeks.
• The syndrome of Zollinger-Ellison is the initial dose of 60 mg per day, the maximum is 100 mg. The duration of treatment is individual for each patient.
• Symptomatic therapy GERD (without esophagitis) - 10 mg 1 time per day for 4 weeks or until the disappearance of painful symptoms.
• Eradication of H. Pylori infection in combination with antibiotics - the dosage is individual, the treatment should not last longer than 7 days.

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Use Barol during pregnancy

Treatment of peptic ulcer of the stomach and duodenum in future mothers has certain difficulties. Since the use of many medications during pregnancy is contraindicated. Under the ban and gets Barol. Its active substance penetrates the placental barrier and into breast milk.

The proton pump blocker is not prescribed for the treatment of patients of childhood. It affects the reaction rate, so it is not recommended for use with machinery and vehicles.

Contraindications

Barol is not allowed for use with individual intolerance to rabeprazole and other components that make up its composition. Contraindications for use apply to pregnant women and children. Medication is not prescribed for patients with malignant neoplasms.

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Side effects Barol

As a rule, Barol is well tolerated. Side effects occur when non-compliance with medical recommendations and have a slight or moderate severity.

• Most often, there are violations from the liver and digestive tract: nausea, vomiting, diarrhea, abdominal pain, flatulence, constipation. In rare cases: a violation of taste and activity of hepatic enzymes.
• The drug can cause pathologies of the hematopoietic system: leukopenia, thrombocytopenia. Possible problems of the nervous system: headaches and dizziness, drowsiness, depression.
• Barol can provoke allergic reactions: itching and rash, bronchospasm, angioedema.

Other side effects include: pain in the back and chest, sinusitis, pharyngitis, calf muscle cramps, urinary tract infections, visual impairment and body weight.

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Overdose

If the recommended dosage or duration of treatment is exceeded, unfavorable symptoms appear. Overdose manifests as: headaches, excessive sweating, nausea and vomiting, dry mouth, increased adverse reactions.

There is no specific antidote, symptomatic, supportive therapy is recommended.

Interactions with other drugs

It has been experimentally established that rabeprazole has a weak interaction with other drugs. To achieve the desired effect of treatment, Barol can be used in combination with additional means.

Rabeprazole reduces the gastric secretion of hydrochloric acid, it affects the pharmacokinetics of medicines, whose absorption is based on the acidity of the gastric juice. The drug lowers the concentration in the blood plasma of ketoconazole and increases the concentration of digoxin. Interaction with other drugs is made and controlled by a doctor.

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Storage conditions

Tablets should be kept in their original packaging, protected from sunlight, moisture and out of reach of children. Recommended temperature is up to 25 ° C. Compliance with storage conditions prevents premature damage to the medicament.

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Shelf life

Barol is recommended to be used within 24 months from the production date. At the end of this period, the tablets should be disposed of and forbidden to take. The spoiled Barrol causes uncontrollable adverse reactions.