B-insulin S.C. Berlin-Chemie

B-Insulin S.S. Berlin-Chemie is an insulin of the average period of action. 

There are several forms of insulin that are used to treat diabetes. B-Insulin S.S. Berlin-Chemie - pig insulin. Thanks to the medication, the blood glucose level is normalized.

If you are diagnosed with prediabetes, you can adjust your condition simply by changing your lifestyle, increasing physical activity, eating properly, eating low-calorie foods and focusing on fruits and vegetables.

Preoral drugs control glucose in people whose pancreas continues to produce hormone.

However, if the doctor decides that hormone therapy is necessary, you will need to pick up a remedy depending on your lifestyle, age and other factors.

The medicine uses human and porcine hormone. Human hormone is used in medicine recently - only 20 years. He has his shortcomings: in patients there is an increase in body weight and increased appetite. The human hormone is cheaper than a pig. Injections are safe and painless. In 1978, scientists managed to "force" the E. Coli to produce human insulin. In 1982, the Americans began selling it. Unfortunately, the domestic industry does not produce a human hormone.

However, for the last 10 years the world pharmacology has been puzzled by the search for an analogue of human and porcine insulin. Such insulin already appears and is being introduced into medical practice. Their injections are painless and safe. Analogues of insulin begin to "unfold" in the blood faster and do not cause allergies.

However, I would like to focus on the pork insulin of the middle period of action of S.S. Berlin-Chemie.

B-Insulin S.S. Berlin-Chemie is the drug of choice in the treatment of diabetes, both in combination with antidiabetic tablets and short insulins, and in isolation.

[1]

Indications B-insulin S.C. Berlin-Chemie

Indications for the use of the drug are: type I diabetes mellitus, type II diabetes mellitus.

[2], [3], [4],

Release form

Form of release of the drug - injection solution 40 U / m.

[5], [6]

Pharmacodynamics

Pharmacodynamics of the drug is as follows: the drug reduces the glucose in the blood of those who suffer from diabetes. After binding to the cell membrane, B-insulin contributes to the fact that glucose enters the cell and is utilized. The liver increases the synthesis of glycogen as a result of taking the drug. In the form of glycogen, the body stores glucose.

[7], [8], [9]

Pharmacokinetics

B-Insulin S.S. Berlin-Chemie - prolonged insulin. The crystals of the hormone after the injection enter the body in the form of amorphous particles. There is a reaction between insulin particles placed in a medium with an acidic pH and neutral environment of the body tissues. For the drug to work, it takes from 3 to 8 hours. The effect of taking the drug is observed for 16 hours. The higher the dose of insulin administered, the longer it acts. A low dose is absorbed by the body quickly, but its duration is less than that of a high dose of the drug. Be careful: the drug is not administered intravenously!

[10], [11]

Dosing and administration

The drug is administered subcutaneously with a small insulin syringe, 45 minutes before meals. Doses are individual. The approximate dose for adults is 0,3-0,8 U / kg / day in 2 doses (2 / 3-3 / 4 doses - before breakfast and the remainder - before dinner) or 1 time (when combined with other antidiabetic agents in the form tablets), with juvenile diabetes (in combination with short insulins).

Children may have lower doses, but overall the dosage for them is little different. When carrying out combined insulin with prolonged action and short insulin, part B- Insulin SC Berlin-Chemie is about 75-80%.

Use B-insulin S.C. Berlin-Chemie during pregnancy

Use of the drug during pregnancy is permitted. Patients on insulin during pregnancy need to carefully monitor the metabolism, than usual, and always tell their doctor about their pregnancy. Pregnant diabetics need special tactics for managing pregnancy and can even be identified in a hospital.

If the need for a hormone decreases in the first trimester, then from the second trimester, an increase in the body's need for it is expected. After the birth of a child, hypoglycemia may occur, the need for a hormone drops sharply.
During breastfeeding, the necessary dose of insulin can change. Limitations for the use of the drug B-insulin S.C. Berlin-Chemie does not have lactation.

Contraindications

Contraindications to the use of B-insulin: hypersensitivity, an allergy to insulin of immediate type, which can go into life-threatening conditions, anaphylactic shock, generalize.

[12], [13], [14], [15]

Side effects B-insulin S.C. Berlin-Chemie

Hypoglycemia - a decrease in blood glucose levels with profuse sweating. It is characterized by a decrease in blood sugar below 50 or 40 mg / dl (2.8 or 2.2 mmol / l), which can lead to loss of consciousness.

Causes of hypoglycemia:

1. Improved glucose tolerance (spontaneous, as a result of eating low-calorie foods).
2. Skipping meals, a violation of diet.
3. Muscle overload.
4. Overdose of a hormone.
5.  Change in the preparation.
6.  Interaction with alcohol.

Each patient should be aware of the symptoms of a condition such as hypoglycemia. Avoid risky situations.

Hyperglycemia. Diabetic coma occurs as a result of an increase in blood sugar (errors in diet, irregular intake of insulin). The diabetic coma comes slowly.

Symptoms of diabetic coma: thirst, lack of appetite, dry skin, rapid breathing, increased glucose and acetone in the urine. Requires immediate medical attention.

Allergic reactions. Rarely, redness of the skin at the injection site can be observed. Severe reddening with the formation of vesicles, accompanied by itching and the formation of vesicles are the first signs of an allergy of immediate type. If you do not change the drug, anaphylactic shock may begin. It requires identification in the hospital, emergency care.

It is rare to form antibodies. Atrophy and necrosis develop at the site of the injection.

Other adverse reactions. Edema and obesity. Over time, these phenomena pass.

To properly choose insulin for therapy against diabetes, you need advice from a therapist or an endocrinologist. Usually, treatment always begins with the appointment of human insulin before bed, the minimum dose of which is 10 IU.

However, if the sugar in the blood reaches a level of 12 mmol or more, you will be assigned short insulin.

[16],

Overdose

Symptoms of an insulin overdose: hunger, tachycardia, nervous excitability, pallor. The forehead of the patient is covered with perspiration. Possible headaches, behavioral disorders. When developing hypoglycemia, you need to eat sweet. If the condition is severe, it is necessary to inject glucagon (0.5-1 mg) intravenously. 

[17], [18], [19], [20], [21], [22],

Interactions with other drugs

Hypoglycemia is strengthened by alcohol, MAO, MAX antibiotics, tetracycline-based antibiotics, acetylsalicylic acid, amphetamines. Weakening hypoglycemia is facilitated by the intake of diuretics, hormonal contraceptives, heparin, lithium and nicotinic acid preparations, glucocorticoids.

Some drugs, for example, reserpine and salicylates, can both strengthen and suppress the action of insulin.

Some drugs can mask symptoms of hypoglycemia, for example, clonidine.

B-insulin is incompatible with alcohol intake.

[23], [24], [25], [26], [27]

Storage conditions

Store at a temperature of 2 to 8 ° C. Do not freeze the drug and store it out of the reach of children. Insulin is optimally stored in the refrigerator, but you can also indoors for a short time and so that it is not in the sun. During flight on the plane, store insulin to yourself so that it does not freeze in the trunk. Do not store the drug in places that are constantly hot.

[28], [29],

Special instructions

It is important to inject each time in another place. Ask your doctor to teach you how to administer the drug.

Shelf life

Shelf life of the drug is 24 months.

After the first selection from the vial, the medicinal product has a shelf life of 3 weeks when stored in a refrigerator.

[30]