Razol

Razol is a medicament for treating lesions of the gastrointestinal tract. Consider the main indications for its use, contraindications, dosage and other features of the medication.

The active component of the drug is rabeprazole, one tablet contains 10, 20 mg of this substance. Its pharmacological group is proton pump inhibitors. The drug is released in the form of tablets and lyophilized powder for the preparation of injections and solutions. 

Razol is used only for medical purposes. Compliance with this dosage and duration of treatment is a guarantee of a stable therapeutic effect and no adverse reactions.

Indications Razol

Razol is based on the action of the active ingredients of a pharmacological agent. The medicine is prescribed for the treatment and prevention of such diseases as:

• Duodenal ulcer (active).
• Benign ulcer of the stomach (active).
• Symptomatic treatment of erosive or ulcerative gastroesophageal reflux disease.
• Long-term treatment of gastroesophageal reflux disease.
• Exacerbation of peptic ulcer of the stomach or duodenum with bleeding and severe erosion.
• Symptomatic treatment of gastroesophageal reflux disease (from moderate to very severe).
• Zollinger-Ellison syndrome.
• Prevention of aspiration with acidic stomach contents.
• Eradication of Helicobacter pylori in patients with peptic ulcer of the stomach and duodenum (in combination with antibacterial regimens).

[1], [2], [3], [4]

Release form

The form of the drug - tablets (in a soluble shell), powder for injections and solutions. Depending on the indications for use, the patient is selected the most suitable form.

As a rule, the solution is prescribed in the case when the use of the oral form is impossible. Razole in tablets is released in a dosage of 10 and 20 mg of 10 tablets in a blister pack. The solution is produced in glass bottles, 10 pieces in one package.

[5]

Pharmacodynamics

Pharmacodynamics Razol is based on the activity of rabeprazole. The substance enters the class of conjugated, suppressing gastric acid secretion by inhibiting the enzyme H + / K + -ATPase. This effect is completely dependent on the dosage and leads to inhibition of stimulated and basal acid secretion. After ingestion, the active ingredient quickly exits from the plasma and the gastric mucosa. The substance is rapidly absorbed regardless of the dose and is concentrated in the acidic environment of the gastric cells.

Studies of Razol were conducted on more than 500 patients for two months. The drug does not cause cell changes and does not affect the severity of gastritis, the distribution of H. Pylori, the frequency of atrophic gastritis or intestinal metaplasia. Its reception is not accompanied by systemic effects from the cardiovascular, respiratory or central nervous system. Long-term use of any form of pharmacological agent does not affect the function of the thyroid gland and the level of hormones. Razol does not interact with amoxicillin and does not affect the plasma concentrations of clarithromycin when used simultaneously. 

[6], [7], [8], [9], [10]

Pharmacokinetics

Pharmacokinetics Rasol is represented by the processes of absorption, metabolism, distribution and excretion. The tablets have a shell that dissolves in the stomach, since the active substance is not stable in an acidic medium. Suction begins only after passing the medication through the stomach. Rabeprazole is absorbed rapidly, the maximum concentration in the blood plasma is observed after 3-4 hours when taking a dose of 20 mg. If you compare the bioavailability of oral administration and intravenous administration, the dose of 20 mg is 52%, without taking into account systemic metabolism, expressed to a large extent. At repeated admission bioavailability does not increase.

Half-life takes from 1-1,5 hours. This process does not depend on the intake of food and the use of the medicine, that is, food does not affect its absorption. Binding to blood proteins is at the level of 97%. Since the active substance belongs to the inhibitors of the proton pump, it is metabolized by the cytochrome P450 system. A single dose does not result in a change in the urine. In this case, a 90% dose is output in the form of two metabolites: a carboxylic acid and a mercapturic acid conjugate, in the form of urine. The remaining 10% come out with calories.

[11], [12], [13], [14], [15], [16], [17]

Dosing and administration

The method of administration and dose are prescribed individually for each patient and depend on the indications for the use of the drug. The maximum dosage of the tablet form is 20 mg per day. Tablets are taken before meals, and the duration of therapy can be up to 8-12 months.

Intravenous administration is recommended in cases where oral administration is not possible. But as soon as oral administration becomes available, intravenous injections are canceled. To prepare injections, use a solution of 5 ml of sterile water for injection and 20 mg of rabeprazole. If the drug is used as an infusion, then it is dissolved in sterile water for injection and 100 ml infusion solution. The drug is administered slowly for 15-30 minutes. The diluted solution can be used within 4 hours after preparation. If there is a sediment or discoloration, then it should be disposed of.

[28], [29], [30], [31],

Use Razol during pregnancy

Use of Razol during pregnancy is not recommended. This contraindication is explained by the negative impact of the drug on the mother and the child's future. To date, there are no reliable clinical studies that would confirm the safety of Razol for this category of patients.

Use of rabeprazole is possible if the expected benefit for a woman is more important than the potential risk of health and normal development of the fetus. If the medication is prescribed after the birth, then it is necessary to stop lactation. Patients do not prescribe medication.

Contraindications

Contraindications to the use of Razol are based on the action of the active components of the drug. Individual intolerance of the benzimidazoles and rabeprazole group is considered an absolute contraindication.

The period of pregnancy and lactation, the age of patients under 18, also apply to the prohibition of the use of the drug. Tablets and injections Razol is not prescribed for patients with renal or respiratory failure.

[18], [19], [20], [21], [22], [23]

Side effects Razol

Side effects of Razol occur when the application rules specified in the manual are exceeded, the dose or duration of treatment is exceeded. Most often, patients suffer from headaches, diarrhea, nausea. Medication can cause dyspepsia, constipation, dry mouth, flatulence. Negative manifestations also arise from the central nervous system: dizziness, drowsiness or agitation, insomnia, impaired taste and vision. Possible violations of the respiratory system, that is, dry cough, bronchitis, pharyngitis, sinusitis.

Rabeprazole can cause allergic reactions, that is, skin rashes and itching. In rare cases, the use of the drug is accompanied by painful sensations in the back, cramps of the calf muscles, fever, increased sweating, leukocytosis, or weight gain. If you experience any of the above side effects, stop taking the medicine and seek medical help to adjust the dosage of Razol.

[24], [25], [26], [27],

Overdose

Overdose is possible when exceeding the recommended dose or prolonged use of the medication. To date, there is no information on overdose, but its symptoms seem to increase the severity of side effects. Treatment involves symptomatic therapy, since there is no specific antidote.

The active substance of the drug binds well to plasma proteins. Dialysis is not effective. In any case, if you have severe symptoms of overdose, seek medical attention. The doctor will revise the dosage or designate a safer analog.

[32], [33], [34]

Interactions with other drugs

Interaction Razol with other drugs is possible in the absence of contraindications. The active component belongs to proton pump inhibitors, therefore it is metabolized by enzymes that are part of the hepatic system of cytochrome P ₄₅₀. The drug does not enter into clinical links with drugs that are metabolized by the enzymes of the CYP450 system (Amoxicillin, Warfarin, Theophylline, Diazepam), but causes a prolonged and pronounced decrease in the production of hydrochloric acid. This indicates normal interaction with drugs whose absorption is based on the pH of the gastric contents.

The relationship between taking medication and food is not revealed. The conducted studies indicate that the active substance has a low ability to drug interaction. There are a number of caveats. Razol for intravenous administration is allowed to dissolve only in physiological saline (sodium chloride) or sterile water for injection. Other solutions are contraindicated for use in infusions and injections.

[35], [36], [37], [38]

Storage conditions

Storage conditions Razol is indicated on the product packaging and in its instructions. If you purchased a tablet form of the drug, then it must be stored in a place inaccessible to children, which is protected from direct sunlight. Storage temperature should not exceed 25 ° C.

Lyophilized powder for the preparation of injections and solutions should be stored in the original packaging. Razol must be protected from direct sunlight. Recommended storage temperature is from 15 to 20 ° C. The prepared solution should be used within four hours, otherwise it loses its medicinal properties and is subject to disposal.

[39], [40], [41], [42], [43], [44]

Shelf life

The shelf life of the tablet form is 18 months, and the powder for injections and solutions is stored for no more than 24 months. After expiration date, the drug is not used. Disposal is also necessary if the integrity of the original package has been violated, the product has changed color or has acquired a smell.

[45],