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Oxyprogesterone capronate
Last reviewed: 23.04.2024
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Indications Oxyprogesterone capronate
Indications for the appointment of oxyprogesterone capronate can serve:
- a habitual and threatening form of spontaneous abortion;
- prevention of spontaneous abortion during surgical operations in this period;
- disorders of the monthly cycle;
- malignant diseases of the uterus and mammary glands.
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Release form
The drug is made in the form of an injectable solution on an oily basis, in ampoules (1 ml of 12.5% of r-ra). The cardboard package contains 10 ampoules.
Composition per 1 ml of the preparation:
- active component - hydroxyprogesterone capronate - 125 mg of dry matter;
- additional components: benzyl benzoate 0.3 ml, olive oil up to 1 ml.
The solution is a clear, oily liquid substance of a light yellowish hue.
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Pharmacodynamics
Pharmacodynamic properties of oxyprogestron capronate are similar to those of natural progesterone. In the body, the active component combines with the surface receptors of certain cells, enters the cell nucleus, which promotes DNA activation and stimulation of RNA production. Akin to progesterone, it helps transform the uterine mucosa from the proliferative phase into a phase of secretion. From the moment of fertilization, it is favorable for the mucosa to acquire a condition that is required for attachment and growth of the embryo-the zygote. Reduces contractility and tone of smooth muscles of the uterus and appendages.
Pharmacokinetics
Oxyprogesterone capronate is a complete analog of natural progesterone. There are only differences in the chemical structure: in position 17, there is a residual amount of caproic acid. Being the etheric substance of hydroxyprogesterone, the stages of exchange are somewhat slowed down by progesterone, therefore its effect is longer.
Absorption of the drug is rapid and complete, both with intramuscular and subcutaneous injection.
Metabolism occurs in the liver, with the formation of compounds with glucuronic and sulfuric acid. Half-life is up to several minutes.
Excretion is carried out through the kidneys (more than half) and the liver (more than 10%), which directly depends on the phase in which the yellow body is located.
With a single intramuscular injection, the solution continues to act for 1 to 2 weeks.
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Dosing and administration
Immediately before use, the ampoule with the solution should be slightly warmed in warm water to 30-40 ° C. If the solution contains microcrystals, the ampoule is heated with a water bath before dissolving. Oxyprogesterone capronate can be injected sc or v / m.
When threat of spontaneous termination of pregnancy, prescribe 125-250 mg of medication once every 7 days, at the discretion of the doctor, until about the 20th week of pregnancy.
For the treatment of amenorrhea, use the drug immediately after the completion of taking estrogen preparations. Assign the administration of 250 mg oxyprogesterone capronate in an amount of one or two times.
For the treatment of polymenorrhea, the drug is rarely used because of its slow action. Use from 65 to 125 mg per 20-22 d.
In the treatment of malignant tumors, the administration of 25% solution in the amount of 3-4 ml of IM every day or once in 2 days for a long time (at the discretion of the doctor from 1 month to 1 year) is practiced.
Use Oxyprogesterone capronate during pregnancy
Oxyprogesterone capronate is prescribed only in the first and in part in the second trimester of pregnancy with the threat of its spontaneous interruption, with insufficient function of the yellow body.
Breastfeeding during the course of treatment should be stopped.
Contraindications
- hypersensitivity to the components of the drug;
- second half of pregnancy;
- cholestasis;
- severe liver disease;
- oncology;
- increased blood viscosity, thrombophlebitis, thrombosis, thromboembolism.
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Side effects Oxyprogesterone capronate
As a rule, the medicine is well tolerated and does not cause side effects.
However, in some cases, the following symptoms may occur:
- fatigue, headache, indifference, depressive conditions;
- cholestasis, attacks of nausea and vomiting, loss of appetite;
- lowering of sexual desire, shortening of the monthly cycle, bleeding in the intermenstal period;
- disorder of visual functions;
- high blood pressure, swelling, thrombosis;
- change in body weight, feeling of tension and tenderness of the mammary glands;
- allergy to the drug;
- feeling of pain at the injection site.
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Overdose
Overdose Oxyprogesterone capronate - this is a fairly rare phenomenon. However, it can be assumed that the use of large doses of the drug over a long period of time can provoke an increase in side effects, as well as rapid heart rate.
Treatment of overdose is carried out according to the detected symptoms.
Interactions with other drugs
Antiepileptic drugs (carbamazepine), antifungal drugs (griseofulvin), barbiturates (phenobarbital), anticonvulsants (phenytoin), anti-tuberculosis drugs (rifampicin) are able to increase the clearance of hydroxyprogesterone capronate.
Oxyprogesterone capronate is able to influence the degree of effectiveness of drugs for lowering blood sugar.
Oxyprogesterone capronate can inhibit the metabolism of cyclosporins, which entails an increase in their amount in the blood and increased toxic effect.
Oxyprogesterone capronate inhibits the effect of oxytocin.
Storage conditions
Storage of the drug is carried out in darkened places with a temperature regime from + 15 ° C to + 25 ° C. Children should not be allowed to store medicines.
Special instructions
Before using oxyprogesterone, capronate should carefully read the instructions. Do not use hormones on your own without the doctor's permission!
Patients with heart and vascular disease, with diseases of the urinary system, as well as those with diabetes, bronchial asthma, epileptic seizures should undergo treatment only under the supervision of a specialist. The same applies to patients during pregnancy and breastfeeding.
During treatment with oxyprogesterone, capronate must be cautious during the management of vehicles and other complex mechanisms.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Oxyprogesterone capronate" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.