Ovestin

Ovestin (Ovestin) is part of a group of hormonal and antihormonal drugs based on natural female sex hormones or their synthetic analogues. ATS code G03CA04; international non-proprietary name - Estriol; producer - the company Schering-Plow (Germany).

Synonyms: Estriol, Estriol micronized, Estrokad.

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Indications Ovestin

Indications for the use of Ovestin are such pathologies as:

• changes in the mucous membrane of the vagina atrophic nature, associated with an age-related decline in the production of estrogens;
• rapid and painful urination in women during menopause, due to a decrease in the level of sex hormones;
• infertility due to damage to the endocervical epithelium and insufficient mucus secretion in the cervix and / or changes in its biochemical composition.

For preventive purposes, Ovestin can be used for urogenital inflammation or after surgery affecting the cervical canal; in some cases is used to provide objective data cytological examination of cervical smears in the diagnosis of diseases of the female sexual sphere.

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Release form

Ovestin is available in the form of tablets (0.2 g each), vaginal suppositories (0.5 g each) and cream (1 mg / g) in tubes (with an applicator for insertion into the vagina).

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Pharmacodynamics

The active active ingredient of the drug Ovestin is the natural hormone estrogen series, synthesized by the ovaries and the adrenal cortex - estriol. When it is administered to women during menopause, the severity of atrophy of the vaginal epithelium and the lower parts of the urinary tract decreases and their normal microbiological state and acidity level of the mucous membranes are partially restored.

By increasing the production of cervical secretion and recovery of microflora, Ovestin creates favorable conditions for conception, as well as decreases the sensitivity of the mucous cervix to extragenital infections.

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Pharmacokinetics

After taking the tablets inside or topically applying suppositories and cream, Ovestin almost completely absorbs into the digestive tract (tablets) or into the vaginal mucosa (suppositories and cream), 90% binding to blood plasma proteins. After oral administration, the highest concentration of estriol in the plasma is observed after 60 minutes, after local use - after 1-2 hours.

Elimination of sulfate conjugates of estriol (estriol-16a-glucuronide) occurs within 24 hours after administration mainly through the kidney (with urine), a small amount of the drug is excreted with bile through the intestine.

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Dosing and administration

Ovestins of any form should be applied once a day, the dosage is prescribed by the attending physician depending on the diagnosis. In case of atrophy of the vaginal mucosa take 4-8 mg of the drug (treatment course - 30 days); suppository and cream are administered by 0.5 mg intravaginally (at night), the duration of application is determined by the doctor individually, it is possible to prescribe a maintenance course of therapy with the use of the drug twice a week.

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Use Ovestin during pregnancy

Use during pregnancy is strictly contraindicated.

Contraindications

Ovestin is contraindicated to use in the presence of bleeding from the vagina, with a suspicion or confirmed oncological diagnosis of the mammary glands or endometrium.

The drug is not used for women with a tendency to clots and embolism (clogging) of blood vessels, with acute forms of liver pathologies and porphyrin disease.

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Side effects Ovestin

Among the most frequently manifested side effects of this drug are irritation or burning of the vaginal mucosa (in case of topical application); engorgement of the mammary glands and painful sensations in them; swelling of soft tissues; nausea; headache; increased blood pressure; muscle cramps; Hyperpigmented spots on the skin.

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Overdose

When taking Ovestina inside, an overdose is expressed in an increase in blood pressure, the appearance of nausea, vomiting and vaginal bleeding. Treatment is symptomatic.

Interactions with other drugs

Ovestin can enhance the effects of steroid drugs and affect the therapeutic effect of adrenolytics and anticoagulants.

For the simultaneous use of sedative drugs based on barbituric acid, butadione and rifampicin, the period of excretion of estriol from the body is shortened, and the combination with such drugs as phenytoin, nevirapine and carbamazepine leads to an enhanced biochemical transformation of Ovestina and, accordingly, to a significant decrease in its effectiveness.

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Storage conditions

The cream and suppository should be stored in a dark place at a temperature of no more than + 25 ° C, tablets - at normal room temperature.

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Shelf life

The expiry date of each forts is indicated on the package.

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