Zalasta q-tab

Zalasta q-tab is a drug designed to achieve a clinical effect in schizophrenia. It is generally accepted by adults to improve the mental state and maintain normal human life. 

Indications of the zalasta q-tab

  Indications for the use of Zalast q-tab - schizophrenia. This medicine is used exclusively by adults. Its main direction is to maintain the clinical effect of prolonged therapy in patients. Especially in those where the response to the initial therapy was observed.

They also use the remedy for moderate and severe manic episodes. Widely used medication and for the prevention of repeated attacks of mania in patients with bipolar disorder. In particular, if a positive result was obtained with olanzapine therapy.

This medicine can not be given to children. In this case, any violations of such a plan must be eliminated in another way. The child's body is not able to transfer the active effect of the drug to itself.

The medication is used solely on the advice of a doctor. In the event that the initial therapy gave a positive result, and there are favorable shifts. Zalast treatment q-tab is really effective.

Release form

The form of release of a medicine - a tablet. The active ingredient is olanzapine. In one tablet it contains 5 mg, 7.5 mg, 10 mg, 15 mg or 20 mg. Naturally, there are auxiliary components, such as mannitol (E421), crospovidone, aspartame (E 951), microcrystalline cellulose, low-substituted hydroxypropylcellulose, magnesium stearate and calcium silicate.

Tablets are completely dispersed in the oral cavity. One package contains 4 or 8 blisters. Each of them has 7 tablets. On average, the medicine is packed into 28 or 56 tablets in one package. This is convenient if the therapy is long.

Medication is easy to use. Because of its softness, remove the tablet carefully and immediately put it on the tongue. It starts to decay in a matter of seconds and thus guarantees a quick effect. The agent immediately penetrates through the mucous membrane of the mouth and salivary glands into the body. To date, Zalasta q-tab is really a powerful tool in the fight against bouts of schizophrenia. 

Pharmacodynamics

Pharmacodynamics Zalasta q-tab - active substance olanzapine. This neuroleptic, anti-manic and mood-stabilizing drug demonstrates a broad pharmacological profile in many receptor systems. Due to its rapid response, the medication has become particularly prevalent. It is enough just to take the pill and put it on the tongue. The result will be available in a matter of seconds.

Olanzapine has a range of affinity for receptors (Ki <100 nM) for serotonin 5 receptors HT2A / 2C, 5 HT3, 5HT6, dopamine D1, D2, D3, D4, D5, cholinergic muscarinic receptors ml-m5, α1-adrenoreceptors and histamine receptors H1. All this confirms the true possibility of a drug to fight even the most complex cases.

Olanzapine demonstrated greater affinity in vitro for serotonin 5HT2 than for dopamine D2 receptors, and greater activity for 5HT2 than for D2 in in vivo models. Zalasta q-tab is a powerful tool in the fight against bouts of schizophrenia. 

Pharmacokinetics

Pharmacokinetics of Zalast q-tab - tablets, which quickly dispersed in the oral cavity. The main component of the drug is absorbed immediately after ingestion. Its maximum concentration in plasma is reached within 5-8 hours. Eating does not affect absorption in any way.

Absolute oral bioavailability relative to bioavailability after administration is not determined. The drug is metabolized in the liver due to the conjugative and oxidative pathways. The main circulating metabolite is 1 0-N-glucuronide. It does not cross the blood-brain barrier. Cytochromes P450-CYP1A2 and P450-CYP2D6 participate in the formation of metabolites of N-desmethyl and 2-hydroxymethyl.

As for clearance, in elderly people it is much lower, in comparison with young people. A similar situation develops in women compared to men, and those who smoke, with those who abandoned this addiction.

The active component binds to plasma proteins by about 93% over the entire concentration range of about 7 to about 1000 ng / ml. In general, the main binding occurs with albumin and α1-acid-glycoprotein. Such is the pharmacokinetics of the preparation of Zalast q-tab.

Dosing and administration

The method of administration and dose are discussed individually with the attending physician. Tablets can quickly disperse in the oral cavity. Therefore, because of their physical properties, they are fragile. This indicates that the remedy should be carefully removed from the blister and placed immediately into the oral cavity. Do not use water, the tablet breaks up quickly.

The recommended initial dose for people with schizophrenia is 10 mg per day. With manic syndrome, this is 15 mg for monotherapy and 10 mg for combination therapy. To prevent recurrence, 10 mg per day is used. The dose can be adjusted in accordance with the individual clinical state of a person in the range of 5-20 mg per day.

Elderly patients do not decrease the dosage, it is also 10 mg per day. If the kidney and liver function is impaired, it is advisable to apply 5 mg of the drug. The increase in dosage in this case occurs with extreme caution. Zalasta q-tab must be taken according to the individual characteristics of the body and based on a problem that should be eliminated. 

Use of the zalasta q-tab during pregnancy

Using qlast during pregnancy is a separate issue. Thus, adequate and well-controlled studies on the effect of the drug on the body of a woman and a child are absent in this period.

The experience of treatment of pregnant women with this medication is limited. Therefore, during this period it is not recommended to resort to the help of this tool. Naturally, you always need to make a comparison. The positive effect for a woman should be much higher than the negative impact on the developing organism. Only in this case the reception is expedient.

In children whose mothers used this drug in the third trimester, there is a risk of adverse reactions. Including extrapyramidal disorders and / or withdrawal syndrome, the symptoms of which may vary in strength and duration. There were cases of hypertension, tremor, drowsiness and eating disorders. Therefore, the state of the child should be carefully monitored.

Healthy women who breastfed the baby, while taking the drug, did not notice any negative impact. Naturally, the active ingredient penetrates into the milk. The average safe dose for a baby is 1.8% of the maternal dose. But nevertheless, Zalasta q-tab during pregnancy and during lactation is not recommended. 

Contraindications

Contraindications to the use of Zalast q-tab - increased hypersensitivity to active substances. In this case, it is extremely undesirable to use the medication. This can lead to a serious allergic reaction from the body. A similar situation develops if a hypersensitivity to any inactive ingredient of the drug is observed in a person. That is why it is extremely important to consult a doctor about treatment.

If non-compliance with certain rules, there is a risk of developing a closed-angle glaucoma. This will entail a worsening of the state. Perhaps the development of more severe consequences. The organism is able to respond in a peculiar way to this medication. Especially if some of its components cause an allergic reaction. This indicates that the best way to not harm it is to consult a doctor. Zalasta q-tab is an effective tool that must be taken after consultation with a specialist in order to avoid the development of adverse reactions. 

Side effects of the zalasta q-tab

Side effects of Zalast q-tab make up a whole list. So, they can arise against the background of the failure of the body to take the main component or auxiliary substances. Naturally, there are cases of a significant excess of the dose, which will lead to the appearance of negative reactions from many organs and systems.

Especially often the following side effects appeared: drowsiness, increased cholesterol, glucose, appetite improvement, dizziness, dyskinesia, asymptomatic increases in liver transaminases, rashes, swelling and fatigue.

From the side of the circulatory system, development of leukopenia, thrombocytopenia, neutropenia and eosinophilia is not ruled out. The immune system is able to respond with a powerful allergic reaction. On the part of the digestive system, weight gain, development or aggravation of diabetes and hypothermia are not ruled out.

The nervous system is able to respond with drowsiness, parkinsonism, dizziness, epileptic fits, lethargy and akathisia. From the side of the cardiovascular system, bradycardia, ventricular tachycardia and even sudden death are not excluded.

From the side of the liver and bile ducts - an asymptomatic increase in the level of liver transaminases ALT and ASAT. This is typical for the beginning of treatment. Peripheral edema and hepatitis are not excluded.

From the side of the skin - the reaction of photosensitivity and alopecia. The musculoskeletal system is able to react with rhabdomyolysis and arthralgia. On the part of the kidneys, urinary retention, difficulty urinating, and even urinary incontinence are not excluded.

On the part of the reproductive system: erectile dysfunction in men, decreased libido in women and men, breast augmentation and priapism. All of these adverse reactions can cause incorrect or incorrect use of the preparation of Zalast q-tab.

Overdose

An overdose of the drug is not excluded. This is mainly due to a sharp increase in the dosage used or in the presence of hypersensitivity to certain components of the medication.

The main symptoms of an overdose are: an excited state, aggressiveness, tachycardia, a decreased level of consciousness and even a coma condition. There are other negative reactions, which are not so common. Basically it is delirium, coma, convulsions, respiratory depression, arterial hypertension and cardiopulmonary shock. A lethal outcome occurs when a dose of 450 mg is used. There were cases when people survived and after 2 grams of medication.

When there are signs of an overdose, you need to help a person. There is no specific antidote to the drug. It is desirable to induce vomiting in a person by usual gastric lavage. Take special drugs that can cause this reaction is not worth it.

According to the clinical condition, symptomatic treatment and monitoring of the function of vital organs should be started. Including treatment of arterial hypotension and collapse, as well as maintain respiratory functions. Do not use dopamine, epinephrine and other sympathomimetics with a beta-agonist effect. They can complicate arterial hypotension. Zalasta q-tab with improper admission can lead to serious consequences. 

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Interactions with other drugs

 Interactions of qal tabust with other drugs is possible, but with extreme caution. Thus, the inhibitors or inducers of cytochrome P450 isoforms, especially the activity of CYP1A2, can influence the metabolism of the drug.

Smoking and taking carbamazepine can reduce the concentration of olanzapine and thus lead to complete inefficiency. In some cases, a slight or moderate increase in the clearance of olanzapine was noted.

The drug is not able to change the pharmacokinetics of theophylline. Fluoxamine in turn may reduce the ability of olanzapine to metabolize. This can lead to an average increase in the maximum concentration in plasma of fluoxamine by 54%, and for men who smoke, by 77%. Patients taking fluoxamine should consume olanzapine in a reduced dose.

Activated carbon reduces orally the bioavailability of olanzapine by 50-60%. Therefore, it should be taken 2 hours before or after olanzapine.

Inhibitors of CYP2D6. Fluoxetine entails an average increase in the maximum concentration of olanzapine by 16% and an average decrease in the clearance of olanzapine by 16%. There was no interaction of the drug with lithium or biperidene.

Antihypertensive drugs. The medication can significantly enhance the effects of certain medications. Therefore, take it with caution. All this indicates that the Zalasta q-tab should be used only with the permission of the doctor. 

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Storage conditions

Storage conditions for the q-tab must be observed. A special role is played by the temperature regime. It is desirable that it does not exceed room temperature. It should be a dry, warm place without excess moisture and direct sunlight.

It is extremely important for the medicinal product to observe special storage conditions. It is desirable that during the whole time the medicine is stored in the original packaging. Children should not have access to this medicine. By mistake, they can take it and thereby cause a strong allergic reaction of the body and symptoms of an overdose. In a large dose, the drug can lead to death.

It is desirable that the product is in the medicine cabinet and removed only when necessary. Correct observance of all the above conditions will lead to the fact that no one will suffer and the medication will serve a person for a given period. Zalasta q-tab is a powerful remedy that can benefit and cause serious harm to the body. 

Shelf life

Shelf life of the drug is 3 years. But without observing special storage conditions, these are just numbers. It is desirable that the drug is always in its original packaging. Changes in the external qualities of tablets, as well as smell and taste indicate that it is not worth taking. There is a risk of serious complications. The integrity of the package and blister must be constantly monitored.

A special role is played by the temperature regime. It is desirable that it does not go beyond 15-25 degrees. A warm dry place without direct sunlight is an ideal condition for this drug. It is important that children do not have access to a medication. Toddlers in any case should not take this remedy. It has a powerful effect and, if misused, can cause a number of negative reactions from many organs and systems. For a child, the use of any dose of this drug can lead to death. Zalasta q-tab has a positive effect exclusively for adults in view of their individual characteristics. 

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