Difluzol from thrush

Thrush belongs to the group of fungal pathologies, the causes of which are quite diverse. Defeat of fungi of the genus Candida is observed both in the outer covers and in the internal organs.

Difluzole from thrush is considered the optimal medication, which due to its composition has a fatal effect on the fungus and eliminates the unpleasant clinical manifestations of the disease.

The cause of thrush can be a violation in the immune system as a result of changes in the hormonal state, a prolonged course of antibiotics, diabetes mellitus and chronic pathology, for example, cancer, tuberculosis or HIV infection.

Difluzole, according to the ATS code refers to antimicrobial agents for use in systemic lesions. In frequency, it is an antifungal drug - a derivative of triazole, namely fluconazole.

[1]

Indications of the difluzole from thrush

Depending on the stage of the pathological process, the milkman can cover both mucous membranes of internal organs and external skin.

Indications for the use of difluzole from thrush include the emergence of clinical symptoms of the disease such as: swelling, hyperemia of varying intensity, a sensation of tingling, itching and burning, and the formation of a white-tinged curd.

Women are more likely to milk a thrush than men. Symptoms of the disease can be noted in childhood and in pregnant women. It should be noted that it is in the evening and at night that the intensity of thrush manifestations increases, as well as after warm procedures.

Indications for the use of difluzole from thrush suggest the presence of genital candidiasis, including vaginal candidiasis, an acute or recurrent form of candidiasis balanitis. The drug is widely used to treat thrush and as a prophylaxis with frequent repeated episodes of the disease.

[2]

Release form

The active substance of the medicamental drug is fluconazole. For more convenient use, the manufacturer has produced several types of dosages for individual selection for each individual case.

The form of the release is a tablet preparation, namely capsules. The dosage can be 50 mg, 100 mg or 150 mg. In addition, the packages also vary in the number of capsules. So, they can contain 1, 2 or 7 capsules.

Such packages are necessary in order to choose a dosage corresponding to the severity of the pathology. The main physicochemical properties of the capsule are a hard gelatinous surface and a different color depending on the dosage.

The capsule contains a white odorless powder. This form of release does not allow the use of Difluzole in infants younger than 6 years of age. At an older age, you should carefully select the dosage and set the duration of intake in order to avoid overdose and suppression of normal human microflora.

[3], [4], [5]

Pharmacodynamics

As is known, fluconazole is considered to be the main active component of Difluzole. The latter, in turn, refers to a class of medicinal preparations consisting of their triazole derivatives that affect the fungus.

The pharmacodynamics of difluzole from thrush is based on the ability of the drug to selectively inhibit the synthesis of sterols in fungal cells. The drug has proven itself in the fight against mycosis, the cause of which are the most common species of fungi (Candida spp, Histoplasma capsulatum? Microsporum spp.).

Difluzole is considered a highly specific antimycotic medication, which, thanks to fluconazole, can inhibit the growth of fungi and contribute to their death.

Pharmacodynamics difluzola from thrush is expressed in a decrease in the activity of enzymes of fungi, which has a negative effect on the formation of new cell membranes. In addition, there is an increase in the permeability of cell membranes, disruption of fungal growth and their multiplication.
 

[6], [7], [8]

Pharmacokinetics

Since difluzol is intended for internal oral administration, its absorption is carried out in the organs of the digestive tract. This process occurs quite quickly, in addition, it is not affected by the preliminary intake of food.

The pharmacokinetics of Difluzole from thrush provides a maximum level of the concentration of the main active substance in the blood within 30-90 minutes after taking the drug on an empty stomach.

Only 10-12% of the absorbed substance is transported by the blood flow by attaching to plasma proteins. After 30 hours, half the dosage remains in the human body, which was taken the day before.

The pharmacokinetics of difluzole from yeast infection is characterized by bioavailability exceeding 90%. Fluconazole easily penetrates into all media and tissues of the body. In comparison of the concentrations with serum, fluconazole reaches a maximum in the horny epidermal layer, epidermis, dermis and secretion of sweat glands. However, the main accumulation of the drug is observed in the stratum corneum of the epidermis.

Removal of medication is carried out by the kidneys. About 80% of the drug is excreted unchanged in the urine.

[9], [10], [11], [12], [13], [14]

Dosing and administration

The daily dose of the drug directly depends on the degree of severity of the pathology and the presence of concomitant disorders in the work of the whole organism. With prolonged use of fluconazole, regular blood test should be performed using laboratory tests.

The method of administration and dose for thrush is usually 150 mg for a single dose. To reduce the likelihood of repeated occurrence of thrush, it is recommended to take 150 mg once a month. Depending on the prevalence of the fungal process, the therapeutic course can be from 4 months to a year.

If, for several months with a dose of 150 mg, the clinical manifestations of thrush are preserved, then the dosage and the frequency of application of diflucol must be reviewed. With the preventive purpose for frequent recurrent disease, the dose of a single dose can be increased 400 mg. Such a dose selection should be done only by a doctor

The way of application and dose in childhood should be counted on the weight of the child's body. Babies under 6 years of age are not allowed to use Difluzole. Depending on the severity of the disease, it is necessary to monitor the dose and duration of administration.

[20], [21]

Use of the difluzole from thrush during pregnancy

The long process of bearing the fetus is very responsible and rather difficult for the woman and the fetus. In this regard, a large number of studies on the use of medicines during pregnancy are not given the opportunity. This is due to the fact that any negative impact of the drug on the fetus can lead to a disruption in its development and in the subsequent inadequate functioning of the organs.

The use of difluzole from thrush during pregnancy also does not have enough research, so it should not be recommended. It is possible that high doses of fluconazole exceeding 400-800 mg over a long period may cause congenital malformations of the fetus.

The use of difluzole from thrush during pregnancy can be tolerated only if the fungal infection threatens the life of a woman and the course of pregnancy. Without his admission, the state of health can worsen. Comparing the benefits for the pregnant woman and the risk for the fetus, the doctor can allow the use of Difluzole.

In addition, do not forget that during the lactation period, it is also not allowed to use Difluzole without consulting a doctor.

Contraindications

Among the most common contraindications for all medicines is the individual characteristics of each person and intolerance of the main or auxiliary components of the drug. Difluzole is not an exception, as there is a possibility of unfavorable response to fluconazole or other azole compounds, which are similar in chemical structure.

Contraindications to the use of difluzole from thrush include its simultaneous use with medicinal agents that are capable of increasing the QT interval.

In addition, it is necessary with extreme caution to use fluconazole in severe form of renal failure and liver damage. There is a possibility of minor changes in laboratory parameters, with which the work of the liver is controlled.

However, in case of aggravation of clinical symptoms of liver damage and significant deviations in blood tests, the use of fluconazole should be discarded.

With care, it is necessary to apply the drug in case of extensive fungal lesions of the skin to avoid aggravation of the condition (toxic epidermal necrolysis).

Contraindications to the use of difluzole from thrush are the prevention of simultaneous reception of this drug with terfenadine.

[15], [16],

Side effects of the difluzole from thrush

Each organism can react to the administration of the drug in different ways, manifesting its side effects. This depends on the degree of tolerance of the drug components and dosage.

Side effects of Difluzole from thrush can manifest mild dizziness, pain in the temporal and occipital areas of the head, tremors, sleep disturbances, changes in taste and tactile sensations.

In some people, the digestive system reacts to the oral administration of diflusol by a violation of the functioning of the intestine, pain in the abdomen, dry mouth, increased gassing in the intestine, and vomiting.

Side effects of Difluzole from the thrush on the part of the blood are manifested as a decrease in the level of leukocytes, including neutrophils, and platelets.

The immune response can be expressed in the anvil of anaphylaxis, in particular, angioedema, edema of the face, itching and urticaria.

Also, do not forget about the increase in cholesterol, triglycerides and a decrease in the amount of potassium in the blood. Skin and fiber suffer in the form of alopecia, exfoliative dermatitis, rash, increased sweating and acute widespread eczematous pustules.

[17], [18], [19]

Overdose

If the recommended dosages are not followed and the drug is used for a long time, the risk of overdose increases. It is especially important to monitor the dose in childhood.

Overdose of the drug in most cases is manifested in the form of pronounced side effects. Some people may experience hallucinations and paranoid behavior.

The state of overdose should be treated symptomatically after special "cleaning" procedures. First, you should wash the stomach to stop further supply of the drug to the common bloodstream and remove the remains from the body.

An effective method is hemodialysis, due to which after 3 hours in the blood of a person the concentration of fluconazole decreases by 2 times. In addition, you need to use "forced diuresis" to speed up the process of excretion of metabolites of the drug, since most of the medication is filtered by the kidneys.

All of the above procedures must be performed exclusively in a hospital under the supervision of a doctor.

[22], [23], [24]

Interactions with other drugs

If several drugs are used simultaneously, their compatibility must be taken into account and should be taken into account when choosing the dosage. Thus, the interaction of difluzole from thrush with other drugs, such as anticoagulants, can manifest itself as bleeding - cavitary (the organs of the digestive tract, urinary system), as well as in cellulose with the formation of hematomas.

These complications are due to the fact that fluconazole increases prothrombin time, especially in people who take warfarin.

With the simultaneous administration of fluconazole and benzodiazepine short-acting agents, an increase in the concentration of difluzole was noted until the occurrence of psihomotor reactions. It is necessary to carefully monitor the condition of a person after their simultaneous application.

The interaction of difluzole with thrush with other drugs, for example, hydrochlorothiazide, manifests itself in the form of an increase in the concentration of fluconazole, however insignificantly, that does not require a reduction in the dose of the antifungal agent.

Fluconazole is able to increase the concentration of phentoin up to a significant level with the appearance of clinical symptoms. In order to avoid the development of adverse reactions, doses of fentoin should be carefully selected.

With the combined use of Difluzole and sulfanylurea derivatives, one should remember the possible development of hypoglycemia, since fluconazole is able to prolong the time of the presence of sugar-reducing drugs in the human body.

Also take caution with fluconazole with tacrolimus, terfenadine, theophylline, zinovudine, astemizole, erythromycin, pimozide, amitriptyline, amphotericin, carbamazepine, celecoxib, cyclophosphamide, fentanyl, HMG-CoA reductase inhibitors, losartan, methadone, NSAIDs, prednisolone and vitamin A.

[25]

Storage conditions

In order for medication to retain its therapeutic effects throughout the expiration date and do not harm the person, their storage conditions must be taken into account.

The manufacturer in the instructions must indicate them in order to avoid damage to the medicinal product. Conditions for storing Difluzole from thrush are to maintain optimal temperature, humidity and light in the room where the drug is supposed to be stored.

So, the temperature of the storage place should not be above 25 degrees and it is necessary to ensure that direct sunlight does not reach the package or capsule.

The storage conditions necessarily imply a place for a medicinal product where the kids will not have access. When a capsule is taken orally, a child may develop an obstructive syndrome with a lack of air, which leads to a life-threatening condition. Also, an overdose is possible, since babies can take several capsules.

[26], [27], [28], [29], [30]

Special instructions

Difluzole reviews from thrush

The drug is very common for the treatment and prevention of thrush. Especially often the drug is used by girls. Difluzole reviews from thrush mainly take a positive side.

The objectivity of their evaluation is impossible, since the cause of thrush in women is not known, as well as the correctness of compliance with the frequency of intake and dosage.

However, it is still worth noting that most of the women had the desired effect, so they have positive responses to the dysfluzole from the yeast infection.

To some women monotherapy with difluzolom did not lead to the desired result, but in the future, with the addition of antifungal vaginal suppositories thrush was defeated.

One third of women noted that after using difluzole, the disease receded, but not for a long time. Clinical symptoms of thrush came back in a few weeks. In this case, women had to re-take capsules.

Difluzole from thrush is a very popular remedy, but it is worth noting that not always one medicinal preparation is able to cope with a fungal lesion. In this regard, it is recommended to carry out complex treatment with the addition of antifungal suppositories.

[31], [32], [33], [34], [35], [36]

Shelf life

In the production of a medicinal product, its expiry date must be indicated. The date of manufacture and the last day of use is applied to the outer carton pack, as well as to the blister with capsules.

The expiry date should be located in a quickly accessible place, because at its expiration the use of any medicinal preparation is prohibited.

This is due to the fact that after the date of the last use in the preparation, the chemical structure may be violated, which leads to a loss of therapeutic properties. Such a drug can bring a lot of harm to a person and even threaten his life.

To ensure that throughout the shelf life of the drug remained in its original composition and benefits it is necessary to comply with the rules for its storage. Having opened the cell of the blister and delivered the capsule, it should be taken, otherwise the medicinal product loses its medicinal properties in the open air.

[37], [38], [39], [40], [41],