Decamethoxin

 We bring to your attention a recommendation on the medical use of antiseptic and disinfectant medication Decamethoxin. This description of the medicinal product is for informational purposes only and should not be used for self-treatment, without prescribing a physician. 

 Decamethoxin is allowed for over-the-counter vacation in pharmacies.

[1], [2], [3], [4]

Indications of the decamethoxin

The medication is indicated for use in the following conditions:

• purulent and fungal dermatological diseases (phlegmon, carbuncle, mycosis, etc.);
• inflammatory process of the distal part of the large intestine (proctitis);
• purulent inflammation of the conjunctiva of the eyes;
• inflammatory reactions in the oral cavity (inflammation of the gums, periodontal);
• angina, inflammatory processes in the ear, inflammatory pathology of the respiratory-pulmonary system.

 Decamethoxin can be used as an antiseptic drug in disinfecting the surface of the hands of medical specialists and the location of the operation, as well as for aseptic surgical instruments, expendable surgical dressings, apparatuses, or for sterilization and storage of a tendon or bone graft. 

[5], [6]

Release form

 The medication is made:

• in the form of tablets of 100 mg for the manufacture of r-ra;
• in the form of 0.05% of alcohol-based solution (drops in the ears), in glass dark jars of 10 ml;
• in the form of 0.025% of alcohol-based rug for surface use, 100 ml in a glass or polymer bottle.

 The composition of the solution: decamethoxin (25 mg dry weight per 100 ml r-ra), ethanol 96%, glycerin, purified water.

[7], [8], [9]

Pharmacodynamics

Decamethoxin is considered a sufficiently effective antiseptic, is an ammonium derivative. By creating concentrations on the cytoplasmic membrane of a bacterial cell, it binds to the phospholipids of the envelope and causes disturbances in its permeability.

 Decamethoxin has a significant antimicrobial effect against streptococci, staphylococci, diphtheria rods and pseudomonas, shows activity directed against yeasts, molds, trichomonads, lamblia.

 Resistance to the drug in bacteria develops slowly. Concentrations of the drug, sufficient to slow the growth of bacteria, are approximately equal to the concentrations that are detrimental to bacteria, viruses and fungal infection. 

[10]

Pharmacokinetics

Decamethoxin is used topically in the form of rubs, rinses and lotions, so the degree of absorption of the drug in the systemic circulation is negligible.

[11], [12]

Dosing and administration

Decamethoxin is used externally and intrabronchially (with bronchial pathology).

 If you want to prepare the drug from a pill, then proceed as follows: the tablet is softened and diluted in purified water, saline solution or in alcohol.  

 For the treatment of pustular and fungal dermatological pathologies, 0.5% of the medicinal product is used on a water basis. Such a tool is used for wetting napkins and washing the affected surfaces.

 In fungal diseases, erythrasis or lichen damage, apply napkins moistened in 0.1% aqueous solution of the drug.

 In the inflammatory process of the distal intestine and ulcerative lesions of the colon, a 0.01-0.03% solution is used on a water basis (not on alcohol!) For setting enemas. The procedure is carried out twice a day for 60-100 ml, until the symptoms of the inflammatory process are eliminated.

 With an inflammatory reaction in the oral cavity, 0.025% of the r-r water-based solution is used in an amount of about 100 ml for rinsing. In dystrophic processes against the background of periodontal inflammation in an acute period, irrigation of the affected areas of the gum with a 0.025% solution in an amount of 60 ml is used.

 For the treatment of fungal lesions of the oral cavity, with ulcerative necrotic lesions of the gums, the preparation is used for rinsing the oral cavity with 0.01% aqueous solution up to 4 times a day. Duration of therapy - within a week.

 In the acute course of purulent inflammation of the conjunctiva of the eye (mainly in the postoperative period), a solution (aqueous 0.02%) should be dripped 5 drops into the area of the conjunctival sac, up to 6 times a day.

 Patients with acute otitis media should drip 0.05% solution (per alcohol, 70%) up to 4 times a day in the ear opening.

 Intrabronchial use of 0.02% aqueous solution Decamethoxin, which is prepared in saline solution.

 To disinfect the site of operations and the hands of personnel, a 0.025% water-based solution is used.

 To disinfect instruments and equipment, alcohol solution (70 or 96%) can be used.

 The transplants are sterilized with 0.025% solution. 

[15]

Use of the decamethoxin during pregnancy

 Information regarding the use of decamethoxin during pregnancy is not available. However, in view of the fact that the drug is unable to penetrate the systemic bloodstream, external use of decamethoxin in pregnancy and lactation is allowed, but only after a doctor's prior consultation. 

Contraindications

The only relevant contraindication to the use of Decamethoxin is the hypersensitivity of the organism to the components of the drug, leading to the appearance of an allergic reaction.

Side effects of the decamethoxin

• Sometimes - dryness, irritation of the skin, rash.
•  With intrabronchial injection - a burning sensation in the chest, which is stopped without additional intervention after half an hour after injection.

[13], [14]

Overdose

In view of the fact that the drug does not penetrate into the general circulatory system, cases of overdose are extremely unlikely. 

Interactions with other drugs

Decamethoxin is positioned as a cationic surfactant. For this reason it is not recommended to combine it with detergents (soap, etc.) or other anionic representatives. 

[16], [17]

Storage conditions

Decamethoxin is recommended to store in the temperature range from 15 to 25 ° C, in darkened, protected from children's access places. 

[18], [19]

Shelf life

Shelf life - up to 2 years.