Agiolax PICO

Agiolax PICO in pharmaceuticals is known as Sodium picosulfate. The drug belongs to a large group of drugs that have the ability to act purposefully on the processes of the digestive system and metabolic processes. More accurately Agiolax PIKO can be attributed to a group of laxatives that facilitate the work of the intestines, as a result of which a soft excretion of stool is observed.

Sodium picosulphate is considered a laxative drug, which acts as a contact, that is, when it enters the intestine. Such a tool is not recommended for a long period of time, because the constant help to the intestines can lead to its hypofunction. As a result, without laxatives, he will not be able to cope with his main task in the future.

Agiolax PIKO is allowed to take a short course or just once as necessary. If there is a need for a daily use of a laxative, then it is necessary to consult a physician to determine the cause of bowel dysfunction.

Indications Agiolax PICO

Due to the fact that the drug is a laxative, so the indications for the use of Agiolax PICO include the conditions in which impaired intestinal activity is observed. However, do not forget about other pathologies that require regular cleansing of the body from the products of life.

Thus, all indications for the use of Agiolax PICO can be divided into two groups: with bowel dysfunction and concomitant pathology. The first group should be attributed to atony of the intestine, various types of constipation, except spastic nature. Such conditions can be triggered by changes in food and diet, diseases that require prolonged bed rest, vascular and cardiac pathology, various severe conditions, and also as a result of metabolic disturbances in the body.

The second group of indications for the use of Agiolax PICO consists of conditions that cause instability of bowel evacuation. The drug is widely used in the periods before and after surgery in surgical and obstetric-gynecological practice.

This laxative is recommended for the purpose of facilitating the process of bowel evacuation in the presence of cracks in the anus, enlarged hemorrhoids, myocardial infarction, hernias that do not lend themselves to surgical treatment, severe form of arterial hypertension, and also to prepare the intestine for instrumental research.

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Release form

The form of release in many respects provides efficiency and superiority over other preparations of the certain group of action. Due to the fact that Aniolax PICO is a laxative, therefore its point of application is considered directly the walls of the intestine. Thus, in order to reach the intestine, the preparation must pass through the strong media of the stomach and duodenum and not undergo cleavage.

Based on this information, the form of laxative Agiolax PICO is a lozenge. They have a yellowish tinge. The shape is reminiscent of a rectangle with slightly convex tops on both sides. In order to make it easier to divide the lozenge in the case of a lower dosage, a separating line is marked in the middle.

Since the drug is allowed to be used in children from 4 years, so the pastilles have a pleasant fruity aroma, reminiscent of plum.

Agiolax PICO contains in each lozenge 5 mg of the main active substance - sodium picosulphate. In addition, it is worth paying attention to additional ingredients, such as gelatin, lecithin, glycerin, potassium acesulfame, corn starch, guar gum and plum flavor.

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Pharmacodynamics

Pharmacodynamics Agiolax PICO provides a laxative property of this drug due to the direct influence of the main component of the drug on the intestinal walls. Thus, the active ingredient is sodium picosulfate. In fact, it is a laxative, which has a local effect and belongs to the triarylmethane group.

Activation of this element occurs under the influence of certain enzymes of bacteria called sulfatases. This process is observed in the thick part of the intestine. Further, the release of substances that irritate nerve fibers in the intestinal mucosa is noted, resulting in its stimulation. Thus, the intestinal motility is restored.

However, the pharmacodynamics of Agiolax PICO will not have the desired effect in children up to a year, since the intestinal microflora is not yet developed in them. Because of this, the bacteria are also not completely "populated", so specific enzymes that activate peristalsis can not fulfill their main function.

Pharmacokinetics

Pharmacokinetics Agiolax PICO is caused by direct action in the thick intestine, since as it moves along the digestive tract the preparation is not practically digested and not absorbed. As a consequence, this laxative does not have a stage of transformation in the liver.

Once the drug has reached the large intestine, its cleavage begins with special enzymes of bacteria that are part of a constant normal intestinal microflora. As a result of the reactions, the active form of Agiolax PICO is converted to the release of free diphenol.

Pharmacokinetics Agiolax PICO takes up to 6 hours of cleavage of the drug, so the effect should be expected no earlier than 6-12 hours after its administration. This time interval is due to the release of the active components of the laxative.

Thus, as a result of the presence of only a partial absorption of the drug in the gastrointestinal tract, only a small part of it is found in the plasma.

Due to the fact that Agiolax PICO reduces the reverse absorption of the fluid and increases its output into the intestinal lumen, the load on the organs of the urinary system decreases.

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Dosing and administration

The method of administration and dose depend on the severity of the condition, the age of the person and the presence of concomitant intestinal pathology. Dosage should be strictly observed in order to avoid the development of side effects from an overdose.

Agiolax PICO is taken orally, i.e. By the oral cavity and gastrointestinal tract. It is most rational to use this laxative drug in the evening. This is due to its start of work and the effect, which manifests itself only after 6-12 hours. Thus, the emptying of the intestine is supposed to occur in the morning.

The lozenge can be taken in any way that is most suitable for a person. It must be resorbed, chewed, swallowed in a non-shredded form and washed down with a sufficient volume of liquid.

The route of administration and dose should be appropriate for age. So, for an adult you can take one or two lozenges once a day. Do not forget that one lozenge contains 5 mg of the main active substance - sodium picosulphate. In this regard, the maximum daily dosage should not exceed 10 mg. At the age of 4 years, take 2.5 mg of sodium picosulphate, which corresponds to half the lozenges.

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Use Agiolax PICO during pregnancy

Self-use of Agiolax PICO during pregnancy is not recommended, since every drug that enters the body in a given period should only be prescribed by a doctor.

During pregnancy, frequent violations of the intestine, in particular, in the form of constipation. This is due to pressure on some areas of the intestine of an enlarged uterus. As the fetus grows, the process of emptying the bowel may not occur completely and regularly, so it is necessary to use laxatives. As a result, toxic metabolic products are retained in the body, which leads to additional intoxication.

The use of Agiolax PICO during pregnancy is permitted due to the lack of registration of cases of development of adverse reactions. However, the drug should be taken after the harm of pregnancy and the need for this drug.

During the lactation period, the use of the drug is not desirable, since there are no data on its penetration into breast milk.

Contraindications

Contraindications to the use of Agiolax PICO include its use at the age of up to 4 years. In addition, all contraindications can be divided into pathology relating to the intestine, and the whole organism.

You can not use a laxative drug in the presence of intestinal obstruction of various origins, obstructive processes in the intestine, when loops of the intestine, tumorous formations or other objects cover the lumen, as well as in acute conditions in the abdominal cavity requiring surgery, for example, appendicitis. Also in this group include intestinal diseases with inflammatory genesis, which are in acute stage.

Contraindications to the use of Agiolax PICO, which affect the whole body, include conditions accompanied by severe dehydration, as this drug enhances the excretion of fluid, as well as individual reactions of the body to the action of the main active substance or auxiliary components of the drug.

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Side effects Agiolax PICO

Side effects of Agiolax PICO can manifest themselves from various systems. So, in the presence of individual intolerance, the immune system can provoke the development of various hypersensitivity reactions. This condition is characterized by the appearance of rashes on the skin, nausea, dizziness and even the development of angioedema. Skin manifestations, in addition to the appearance of elements of the rash, may disturb itching and swelling in the area of the rash. In some cases, hives are observed.

On the part of the digestive system, a painful syndrome of a spasmodic nature is possible, especially in the abdomen, intestinal disorders, in particular, diarrhea, and the appearance of flatulence and discomfort.

Since the mechanism of action of the drug implies an effect on the volume of fluid in the body, therefore, the side effects of Agiolax PICO with prolonged use of this drug may manifest as a violation of the ratio of the liquid part of the body and the electrolyte composition. In this regard, the amount of potassium in the body can decrease, which in turn leads to a slowing of the peristalsis.

Overdose

Overdosing involves taking the drug at a higher dose for a long period of time. However, these symptoms can vary depending on the individual characteristics of the body.

In case of an overdose, the following symptoms may occur: a disruption in the functioning of the intestine with the appearance of a loose stool and intestinal pains of a spasmodic nature. In addition, as the loss of electrolytes (potassium and others), develops characteristic symptoms, right up to seizures.

Long-term use of Agiolax PICO, as well as other laxatives, promotes the development of chronic form of diarrhea, persistent pain along the bowel, and also gikokaliemia.

In order to stop the effect of the drug on the human body, it is advisable to induce vomiting artificially or, if possible, to wash the stomach. In addition, if necessary, you must replace lost electrolytes, especially if an overdose is observed in childhood or the elderly. In some cases, the use of antispasmodics.

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Interactions with other drugs

The interaction of Agiolax PICO with other drugs is due to its ability to activate the excretion of potassium and other vital electrolytes with feces. Based on this, it is necessary to control the intake of other drugs, the effect of which can also lead to the loss of trace elements. It can be a means that have an effect on the urinary or hormonal system.

Among the most active drugs should be allocated diuretics, the side effect of which is to reduce the amount of potassium in the body, as well as corticosteroids.

Adverse interaction of Agiolax PICO with other drugs may manifest as a violation of the heart rhythm, pulse conduction in the heart muscle, resulting in arrhythmia. In addition, a deficiency of potassium contributes to the development of muscle weakness.

In the case of simultaneous use of Agiolax PICO with cardiac glycosides, the main effect of which is to enhance the work of the heart, there may be an increase in sensitivity to their effects. As a result, it is necessary to review the dosage of both this laxative and cardiac glycosides.

In turn, antibacterial agents can reduce the activity of Agiolax PICO. This is due to the pharmacokinetics of the laxative, which involves activation of the drug with the help of bacteria in the intestine.

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Storage conditions

Agiolax PIKO storage conditions should be observed, in order to avoid loss of therapeutic activity by the medicinal laxative. In addition, in the process of improper storage of the drug may acquire additional properties, which in the body will manifest themselves as side reactions.

Thus, the storage conditions of Agiolax PICO imply compliance with a certain temperature regime and humidity. The drug retains its medicinal properties during the expiration date, which is indicated by the manufacturer.

In the absence of the required conditions, Agiolax PIKO may become toxic to the organism before the expiration date. This laxative is recommended to store at a temperature of no more than 25 degrees in a dark place without direct sunlight.

Also, do not forget about the inaccessibility of the drug to children in order to avoid overdose, poisoning or ingress of the lozenge into the respiratory tract. It is necessary to observe the tightness of the packaging of each lozenge for the preservation of medicinal properties throughout the specified period.

Shelf life

The expiry date assumes a certain period of time during which the manufacturer of the drug guarantees the preservation of the indicated therapeutic properties. However, it should be borne in mind that the expiration date implies mandatory implementation of recommendations on storage conditions.

The shelf life of Agiolax PICO is 3 years from the date of manufacture of this medication. After the specified period of time, taking any medication is contraindicated.

The date of manufacture and the last date of admission are indicated on the outside of the package. Since one package can contain several blisters of 10 lozenges each, then the blisters also have, on the one hand, the date of the last use.