Lazolvan

The human body is constantly exposed to various negative effects, capable of provoking pathological changes in it, for example, cold or viral defeat. Produced by the Greek pharmacological company Boehringer Ingelheim Ellas A.E. (tablet form and syrup) and Italian corporation Boehringer Ingelheim Italy Sp. A (form of solution for internal administration and inhalation) Lazolvan drug has highly effective secretory, secretolitic and expectorant characteristics.

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Indications Lazolvan

One of the symptoms of acute respiratory viral infection or acute respiratory disease is cough. This is the reaction of the patient's body to external aggression. Therefore, the main indications for the use of Lazolvan are the need to quash the problem associated with the damage to the elements of the human respiratory system, accompanied by the extraction of high-viscosity secretions. The drug shows an equally qualitative result for both the chronic nature of the disease, and in case of acute manifestation of symptoms.

• Pneumonia is an inflammation of the lung tissue, mainly of infectious genesis with a priority lesion of the alveoli.
• Bronchitis is a lesion of the respiratory system, in which bronchi are involved in the inflammatory process.
• Chronic obstructive pulmonary disease (COPD).
• Bronchoectatic lesion is a pathological lesion of the lower parts of the bronchi.
• Bronchial asthma diagnosed with difficulties in the discharge of phlegm.
• Tracheobronchitis.
• Chronic form of rhinitis.
• Sinusitis (inflammation of the paranasal sinuses).
• Cystic fibrosis of the lungs is a pathology of a genetic nature associated with changes that occurred in the seventh chromosome and is characterized by a systemic lesion of the mucus-forming exocrine glands of the respiratory apparatus.
• The need for sanation of the bronchial tree.

Lazolvan is appointed by a therapist or an otolaryngologist in a wide range of respiratory diseases that occur with the formation of significant amounts of viscous sputum. This drug helps dilute the secretions and remove them from the body of the patient.

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Release form

Active ingredient of Lazolvana is known for many substances ambroksol (amrobroxolum), the form of which on the shelves of modern pharmacies is represented by a rather wide variety.

In Greece, the company Behringer Ingelheim Ellas A.E. Athena ambroxol is available in tablets with an active substance concentration of 30 mg (ten pieces per blister), as well as in the form of a syrup, with a concentration and dosage of 15 mg / 5 ml (for children) or 30 mg / 5 ml (for adults). Lately, pastilles have appeared, equipped with the same name and properties. As medications for inhalation, as well as for in-dosing, Beringer Ingelheim Italy SpA Italy, solutions are produced by the concentration and volume of 15 mg ambroxol hydrochloride per 2 ml of the drug (ten ampoules per package).

The syrup is sold in bottles of 100 ml, made of dark glass. The lozenges of the drug are round in shape and have a brownish color, with one unit containing 15 mg of the active substance.

Pharmacodynamics

This medical device is quite effective. Already after half an hour after internal reception its influence which is capable to be supported during six - twelve hours starts to be shown. The duration of the effect depends on the clinical picture of the disease and the general condition of the patient's body. Pharmacodynamics Lazolvan is caused by the stimulation of serous cells of the mucous glands located on the bronchial membrane. Activates the removal of surfactants (surfactant - surfactant) from the bronchi and alveoli.

Ambroxol leads to the necessary balanced ratio of mucous and serous components of excretion, as well as stimulates the release of lysosomes from the structure of cells. Lazolvan activates the function of hydrolytic enzymes, lowers the viscosity of sputum, which contributes to their better excretion. The active substance of the drug raises the activity of the cilia of the ciliated epithelium.

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Pharmacokinetics

The considered preparation differs simply by an unusual speed of absorption of a mucosa of a gastrointestinal tract then it also promptly penetrates into tissue cells. A slight temporal discrepancy yields the pharmacokinetics of Lazolvan in various forms of administration. When using the drug, ambroksol, in tablet form or in the form of syrup, the complete absorption of the chemical compound occurs two hours after ingestion. In the case of a solution that is used in the form of internal drops or during inhalations, this time interval varies from half an hour to three. The percentage of binding, ambroxol, with albumin of blood plasma for tablets and syrup is about 80%, when using a solution, this indicator is slightly higher and approaches 90%.

Lazolvan differs high permeability and easily overcomes, as a hemato-encephalic barrier, the placental barrier, and also gets into the mother's milk. The active substance shows the greatest concentration in the tissue layers of the lungs.

The main metabolites of ambroxol are formed in the liver, transforming into glucuronic conjugates and dibromantranilic acid.

Practically all Lazolvan (in the form of water-soluble metabolites) is excreted from the body through the kidneys with urine (90%). About five percent of the substance is excreted unchanged. The half-life of ambroxol, which has been ingested into the body by a syrup or tablet, is on average about one hour and twenty minutes. The same index for the solution is from 7 to 12 hours. Cumulation of the drug is not detected. In this case, a disruption in the functioning of the liver does not lead to an adjustment of the half-life of the drug, whereas renal failure may significantly increase this index.

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Dosing and administration

This pharmacological agent is prescribed by a doctor for oral administration through the mouth or in the form of respiratory procedures. The method of administration and dose are selected by the attending physician.

The drug in the form of tablets is taken orally, together with the necessary volume of water. The maximum efficacy of the therapeutic dose will be achieved if Lazolvan is ingested after ingestion. For adults, the recommended dosage is one unit (0.03 g) taken three times during the day. If the clinical picture shows medical necessity - the dose of the drug can be increased and determined by two wafers (60 mg) twice a day (morning and evening).

The method of administration and dose of Lazolvana used in the form of a solution depends on the age of the patient and the quantitative component of the basic chemical compound in the preparation:

With a concentration of 15 mg of ambroxol hydrochloride in 5 ml of the drug. Take with food, wash down with water:

• Adults and adolescents who are already twelve years old are recommended to take 10 ml (one tablespoon) three times a day.
• Children from six to twelve - 5 ml (one teaspoon) two to three doses during the day.
• Children from two to six are given 2.5 ml (half teaspoon) three times throughout the day.
• Karapuzam up to two years - 2.5 ml (half teaspoon) twice a day.

With a concentration of 30 mg of ambroxol hydrochloride in 5 ml of the drug.

• Adult patients and adolescents who have reached the age of 12 are recommended to take 5 ml (one teaspoon) three times a day.
• Children from six to twelve - 2.5 ml (half a teaspoon) two - three approaches throughout the day.

The duration of therapy is four to five days. Further medication should be administered under closer monitoring by the attending physician.

The drug in the form of a solution is used orally or in the form of inhalations. Drops of the drug are injected into the patient's body with food. They can be added to tea, milk, fruit juice and so on. For ease of use, it is worthwhile to know that 1 ml of the solution is equal to 25 drops of liquid. The way of application and the dose of Lazolvana taken in the form of drops differ depending on the age group:

Adult patients in the early stages of therapy are encouraged to take 4 ml (100 drops) three times throughout the day. Children older than six years and adolescents - 2 ml (50 drops) two or three doses during the day. To children from two to six - 1 ml three times during the day. Children who are not yet two years old - 1 ml twice a day.

If the attending physician prescribes inhalation with Lazolvan, then patients who are already six years old (including adults) are advised to take one to two procedures daily, using 2-3 ml of medication. Babies under six years of age each have two procedures daily, using 2 ml of ambroxol.

This procedure can be carried out using any device (modern apparatus), excluding steam inhalers. Inhalation liquid is obtained by mixing in equal proportions of saline and ambroxol. The resulting mixture should be slightly warmed up (it should be a little warm, but in no case hot). When conducting a physical therapy should not be inhaled too deeply - this can provoke coughing attacks. Breathing should be calm, in natural mode.

If the patient suffers from bronchial asthma, it is desirable to take any bronchodilator before starting a therapeutic breath.

Use Lazolvan during pregnancy

Preliminary studies and monitoring of various clinical cases have not revealed any, any, pathological changes or manifestations in the treatment of diseases, practicing the use of Lazolvan during pregnancy. But, nevertheless, it is worth to be especially cautious at the time when a woman carries her baby, especially in the first trimester of pregnancy, when all the child's organs are just forming and any failure can cause disability or death. The active substance is easily absorbed into the breast milk of the mother. But it is confirmed by repeated monitoring that the therapeutic dose of ambroxol does not have a negative impact on the newborn.

With a medical indication for the use of Lazolvana, before you prescribe the drug during pregnancy, you should weigh all the pros and cons.

Contraindications

Most pharmacological drugs have multiple inhibitions for use, there are, although not significant, contraindications to the use of Lazolvan.

• Hypersensitivity to the active substance of the drug.
• The first trimester of pregnancy.

More cautiously it is necessary to relate to the appointment of Lazolvan:

• During the second and third trimester of bearing a child by a woman.
• During the feeding of the baby with breast milk.
• With dysfunction of the liver and / or kidney.

Side effects Lazolvan

The use of the drug in question is harmless enough. But very rarely you can still observe some side effects of Lazolvan, mostly allergic reactions:

• Hives.
• Contact dermatitis.
• Rashes covering the patient's skin.
• Very rarely, with an acute manifestation of an allergy, anaphylactic shock can occur.

In the case of long-term therapy and a large dosage taken by Lazolvan, one can observe:

• Gastralgia.
• Heartburn, localized in the digestive tract.
• Nausea may appear.
• Quite likely and vomiting.

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Overdose

No matter how innocuous the drug may seem, but in any case it is worthwhile to carefully follow the recommended dosages. Overdose Lazolvanom rare enough, but still able to cause nausea, which at high intensity can lead to vomitive reflexes. You can also observe gassing in the intestine, a manifestation of gastregia and / or dyspepsia.

When there are signs of an overdose, treatment is symptomatic.

Interactions with other drugs

Before introducing several drugs of different pharmacodynamic orientation into the complex treatment protocol, it is first worth familiarizing with the features of Lazolvan interaction with other drugs.

Sufficiently adequately active substance of the drug in question behaves with drugs that constrain generic activity. It is worth taking Lazolvan with cough suppressants carefully, as they, fighting coughing attacks, block the withdrawal of viscous secretions from the patient's body.

Ambroxol enhances the action and penetrating ability of such drugs as cefuroxime, doxycycline, amoxicillin and erythromycin. This tandem promotes an increase in the concentration of these antibiotics in the lung tissues.

It is not necessary to administer Lazolvan with an acidity of pH 5.0, together with drugs with an acidity higher than 6.3, due to this compound, the free lazolvan is able to precipitate. The results of Lazolvan interaction with other drugs, for the time being, are not yet available.

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Storage conditions

Most drugs must be kept in a place where direct sunlight does not reach. Do not expose the medicine and frost. At the same time, the storage conditions for different forms of output are somewhat different. For example, a solution of ambroxol hydrochloride does not lose its medicinal qualities to a temperature of 25 ° C, whereas tablets, lozenges and syrup remain effective up to temperature values of 30 ° C. At the same time, adults are obliged to ensure that a small child can not reach the storage site of the drug.

Shelf life

Each of the produced forms of Lazolvan drug has its expiration date, which is mandatory displayed on the package. For tablets it is five years, the solution also has a five-year shelf life, but the period of qualitative effectiveness of the syrup varies: a syrup with a concentration of 15 mg per 5 ml has a three year warranty and 30 mg / 5 ml is five years.

It should be noted that it is necessary to closely monitor the end date. And in the event that the boundary number is overdue, it is not worth taking such a medicine.