Gaspospase

The drug Gaspospase refers to synthetic blockers of acetylcholine receptors and is a means of auxiliary treatment of pain syndrome. ATX Code - A03A A31. The manufacturer is Kusum Healthcare Pvt Ltd (India).

Indications Gaspospase

The drug Gaspospazam is used as a symptomatic agent for spasms of smooth muscles and flatulence that accompany such gastrointestinal diseases as colitis, intestinal colic, irritable bowel syndrome, spastic constipation.

As an additional symptomatic remedy Gas-spasm can also be prescribed for diverticulitis, enteritis, gastritis and peptic ulcer of the stomach and duodenum.

Release form

The preparation Gazospazam is issued in the form of tablets of the oval form covered with a cover, and also in the form of a suspension - in bottles of 30 and 60 ml with a measuring spoon.

Pharmacodynamics

Active active substances of this drug - simethicone (in one tablet - 125 mg) and dicyclomine hydrochloride (in one tablet -20 mg). The simethicone is a silicone compound of the dimethylpolysiloxane group. Possessing the properties of a defoamer, simethicone alters the surface tension of gas bubbles formed in the intestine and promotes their destruction. In addition, simethicone hampers the process of gas formation itself.

Dicyclomine hydrochloride is an organic derivative of ammonia-a disubstituted glycolic acid ester (tertiary amine). It acts on the m-cholinergic receptors of the central nervous system and muscarinic receptors of muscle cells that carry neurotransmitters through heterotrimeric membrane proteins. Due to the fact that the transmission of these signals is blocked, spasms of smooth muscles and spasms of the muscle tissues of the internal organs, including the intestine and bladder, cease. Thus, the muscles relax, which leads to the cessation of spasmodic pains.

Pharmacokinetics

Simethicone, being a physiologically and chemically inert substance, in the body is not absorbed and after passing through the gastrointestinal tract is excreted unchanged.

Dicyclomine hydrochloride is rapidly distributed in tissues, almost completely binds to blood plasma proteins, reaching a maximum concentration 1-1.5 hours after taking Gaspospase; the concentration of dicyclomine hydrochloride in plasma (after taking one tablet) is maintained for 24 hours.

The half-life of the drug from the body, during which its concentration is reduced by half, is about two hours. Almost 80% of the gaspase is excreted from the body with urine, the rest - through the large intestine.

Dosing and administration

Gaspazam in tablet form is taken by adults and children over 12 years of age by one tablet 2-3 times a day - 20 minutes before meals.

Dosage of the drug in the form of suspension: for adults and children over 12 years - 5-10 ml no more than 4 times during the day (before or after eating). The maximum daily dose is 40 ml. Duration of admission - no more than five days.

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Use Gaspospase during pregnancy

Use of Gas Spots during pregnancy and during lactation is contraindicated. Also not applicable to children under 12 years old.

Contraindications

Contraindications to the use of this drug are individual hypersensitivity to its components, ulcerative colitis, gastroesophageal reflux disease, H. Pylori-associated gastritis, duodenitis, cholelithiasis, disorders of gastric and duodenal motility, intestinal obstruction (obstruction), retroperitoneal fibrosis, and also caused by obstruction of the pathology of the liver and urinary tract (obstructive chronic pancreatitis, hydronephrosis, neurogenic dysfunction of urine of bladder, etc.).

Side effects Gaspospase

From the side of the central nervous system, possible side effects Gaspasam expressed in the form of dizziness and headache, drowsiness or insomnia, general weakness, movement disorders and conversation. Side effects of this drug on digestion can manifest dry mouth, thirst, difficulty swallowing, nausea and vomiting, swelling and pain in the abdomen, loss of taste and appetite.

In addition, taking Gaspospase can cause visual impairment (pupil dilated and photophobia) and increased intraocular pressure; allergic reactions with rashes, flushing and itching of the skin; dysfunction of the urinary tract; heart rhythm disturbances; lowered sweating, stuffy nose, choking.

When treating this drug to drive a car or potentially dangerous mechanisms is not recommended.

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Overdose

An overdose of the dicyclomine included in Gasospazum causes an increase in the heart rate (tachycardia) and respiration, dry mouth, convulsions, and a state of affect. With these symptoms, it is necessary to: induce vomiting, rinse the stomach, give an absorbent (activated charcoal), deliver to a medical institution.

Interactions with other drugs

It is impossible to apply to the Gaspase simultaneously with anticholinergic drugs (atropine, metacinone, etc.). As a result of the interaction of Gaspospase with drugs that depress the central nervous system and means containing alcohol, a patient's psycho-physiological state may be disturbed. Gasazsam also distorts the therapeutic effects of atropine-like drugs and non-steroidal anti-inflammatory drugs.

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Storage conditions

Storage conditions: In a dry place, protected from light and out of reach of children, at temperatures up to + 25 ° C.

Shelf life

Shelf life of the drug is 24 months.