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Abixa
Last reviewed: 23.04.2024
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Indications Abixa
Abixa is intended for people suffering from various forms of dementia, including senile dementia of the Alzheimer's type.
Release form
Abixa is released in the form of tablets with a strip for separation on both sides, coated with a shell, ten milligrams No. 28, No. 56. The active ingredient is memantine.
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Pharmacodynamics
The drug Abix has a neuroprotective, antispastic and antiparkinsonic effect. The active substance of the drug is an antagonist of glutamate N-methyl-D-aspartate receptors, dulls glutamatergic neurotransmission and the development of neurodegenerative phenomena, has a neuromodulatory effect. The drug has a positive effect on psychoactivity, improves memory, concentration, corrects movement disorders.
Pharmacokinetics
After ingestion, the drug is quickly and completely absorbed, the maximum concentration in the blood is reached within two to six hours. Excretion takes place in two stages: T 1/2 is four to nine hours in the first phase, and forty-sixty five hours in the second phase. Eliminated mainly by the kidneys (seventy-five to ninety percent). With normal functioning of the kidneys, there is no accumulation in the body.
Dosing and administration
The way of application and the dose of the adult drug for adults at the initial stage is half a tablet a day (five milligrams) in the morning for seven days. Over the next week one tablet per day (ten milligrams) is prescribed - half a tablet twice a day. From the third week the drug is taken at a dosage of fifteen milligrams a day - one tablet in the morning and half a tablet after lunch. At the fourth week, the recommended dose is twenty milligrams per day (twice per tablet). In order to minimize the occurrence of unwanted reactions, the dosage is increased by five milligrams in seven days during the first three weeks.
Eating does not affect the effect of the drug. For patients over sixty-five years of age, the recommended dosage is twenty milligrams per day (twice per tablet). For patients with a mildly abnormal kidney function, the dosage does not change. In the case of renal disorders of moderate severity, the daily dosage is ten milligrams. Data on the use of the drug by patients with severe renal impairment, as well as children and adolescents, are lacking.
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Use Abixa during pregnancy
The use of abixa during pregnancy is not recommended, except in cases of extreme necessity. Experiments conducted on animals suggest that the use of the drug is able to slow down intrauterine growth at levels of influence equivalent or slightly larger than in humans. Possible risk to humans is not established.
Contraindications
Contraindications to the use of abix include hypersensitivity to memantine or to any component of the drug, severe impairment of kidney function. With caution is prescribed to patients suffering from epilepsy, as well as patients who have in the past cases of seizures. The drug is able to influence human reactions, so when using it, it is not recommended to drive or work on equipment.
Side effects Abixa
Possible side effects of abix:
- Feeling of anxiety;
- Damage to any organ or part of the body;
- Spontaneous emptying of the bladder;
- Diarrhea;
- Sleep disorders (insomnia);
- Dizziness and headache;
- Hallucinations;
- Stool retention;
- Cough;
- Falls.
Overdose
Overdose of the drug Abix can lead to the appearance of visual hallucinations, loss of consciousness, the development of stupor, as well as cause feelings of anxiety, psychosis, drowsiness. In cases of drug overdose, symptomatic therapy is performed.
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Interactions with other drugs
Interactions of abix with other drugs: the drug abixa is not used simultaneously with N-methyl-D-aspartate antagonists. The simultaneous administration of abix with antispasmodic agents can have an effect on the action of memantine, which in turn can cause the need for dosage adjustment. With the simultaneous use of abix with drugs containing hydrochlorothiazide, a decrease in blood concentration is possible.
Storage conditions
The preparation of Abix does not require special storage conditions.
Attention!
To simplify the perception of information, this instruction for use of the drug "Abixa" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.