Datum

Let's look at the characteristics of the drug Dazel, its pharmacology, interaction with other medicines and much more.

Indications Datum

Indications for use Dazel is a vaginitis that is treated with microorganisms that are sensitive to the drug. Dasel is an antiseptic, an antimicrobial drug that cures gynecological and venereal diseases. Let's consider the indications for the use of Dasel and the drugs that make up its composition.

Flukanisol - is used for various fungal infections.

• In diseases of the central nervous system, which are associated with yeast-like parasitic microorganisms.
• It treats meningitis cryptococcal, that is, inflammation of the brain, which is caused by yeast-like parasitic microorganisms.
• Candidiasis of the mucous membranes, vaginal candidiasis.
• In diseases that can cause the development of fungal infections.

Azithromycin - is prescribed for diseases that are caused by infectious agents.

• Infectious diseases of the upper respiratory tract.
• Inflammation of the paranasal sinuses, tonsillitis, otitis media.
• Infectious diseases of the lower respiratory tract (bacterial pneumonia, pneumonia ).
• Infectious lesions of the soft tissues of the skin - erysipelas, dermatoses, skin diseases.
• Infectious diseases of the urogenital tract - urethritis, inflammation of the cervix.

Seknidozol - is appointed as a synthetic antimicrobial bactericide.

• It fights against anaerobic bacteria and pathogens of protozoal infections.
• Promotes an increase in the sensitivity of tumors to radiation.
• Works at the cellular level, helps to destroy the spiral structure of DNA, rupture of filaments, which contributes to the death of infected cells.

[1]

Release form

Dazel is a combined set of antiseptic drugs that treat problems of an intimate nature, both in women and men. So, the composition of Dasel includes:

• Fluconazole - 150 mg, uncoated tablets.
• Azithromycin - 1 g, coated tablets.
• Secnidazole - 1 g, coated tablets.

The form of the preparation is a tablet. One plastic Dasel, contains three tablets. Let's take a closer look at the composition of drugs Dazel.

One plate of the drug Dasel contains:

• Azithromycin - 1g, 1 tablet

The active substance of the tablet is an azithromycin dihydrate, which is equivalent to anhydrous azithromycin. As auxiliary substances - corn starch, polyvinyl pyrolidone, dibasic calcium phosphate, purified talc and others.

• Fluconazole - 150 mg, 1 tablet

The active substance in the tablet is flucanazole. Excipients - croscarmellose sodium, microcrystalline cellulose, magnesium stearate and others.

• Seknidazol - 1g, 2 tablets

The active substance in the tablet is seksidazole. Auxiliary substances - magnesium stearate, colloidal silicon dioxide,, microcrystalline cellulose and others.

Pharmacodynamics

Pharmacodynamics Dazel is the localization of substances, mechanisms of their action, effects and various factors that are taken into account during treatment.

• Fluconazole - refers to antifungal drugs that effectively affect the bacteria of Candida albicans.
• Azithromycin - an antibiotic, has an antibacterial effect on Chlamydiatrachomatis and Neisseria gonorrhoea, belongs to the group of macrolides.
• Secnidazole is an antiprotozoal drug that has an antimicrobial effect on the infection. Effectively copes with micro-granules that cause bacterial vaginitis and Trichomonas vaginalis.

[2]

Pharmacokinetics

Pharmacokinetics Dazel is responsible for the processes that occur with the drug in the human body. Let's look at how each of the drugs that make up the Dazel's drug complex work in the body.

• Seknidazole - completely, but slowly absorbed in the body. As a rule, the effect of the drug is calculated for 17-30 hours. If the drug is taken by patients with giardiasis or amoebiasis, then the reaction of the body comes the day after taking the medication. In the case of hepatic amoebiosis, treatment lasts for a week. The drug is well distributed throughout the body, and does not concentrate in the placental tissues. The time for which the drug is distributed throughout the body is about 10 minutes. Due to slow absorption, the drug may remain in the intestine. But this is one of the advantages of the drug, since in the intestine it fights against such parasites as amoeba and giardia.
• Fluconazole - oral administration of the drug for its effectiveness of distribution across the body is equal to intravenous administration. The highest concentration of the drug is observed in the blood plasma, 2 hours after taking the drug. But the half-life is about 30 hours. The drug is excreted in the urine, while about 80% of the drug goes unchanged and 10% as metabolites.
• Azithromycin - the drug is well absorbed and very quickly spreads through the gastrointestinal tract. Such speed of the drug is associated with blood plasma proteins. The drug is excreted in the urine, while the bile leaves in an unchanged form.

[3], [4], [5], [6], [7], [8]

Dosing and administration

The method of application and dose of the drug Dazel are designed for the whole complex of medicines in one platinum Dazel.

• Fluconazole is taken - 1 tablet before or after a meal.
• Seiznidazole is taken - 2 tablets with food.
• Azithromycin is taken - 1 tablet 1-2 hours before meals.

Complex of drugs Dazel is designed for a single dose of all drugs. In case of necessity for a repeated course of treatment, the taking of the drug is prescribed by the attending physician.

Please note that during taking the drug, you must stop driving vehicles, drink alcohol and give up work that requires high attention and quick psychomotor reactions.

[12], [13]

Use Datum during pregnancy

Use of Dazel during pregnancy is prohibited, and the drug should not be taken during lactation, that is, breastfeeding.

The drug penetrates the placental barrier and can adversely affect the development of the baby. If the drug is taken in the early stages of pregnancy, it can provoke severe bleeding and miscarriage, and the reception on the last stages of pregnancy - premature birth and even asphyxia in a newborn.

The dasel is excreted in breast milk and enters the body of the newborn. Therefore, during lactation it is necessary to refuse to take the drug or stop breastfeeding.

Contraindications

Contraindications to the use of Dazel are associated with the individual intolerance of substances that are part of the drug. A number of contraindications include:

• Hypersensitivity to any antibiotic, which belongs to the group of makrodiov.
• The age of patients is categorically forbidden for children and adolescents under 18 years.
• Hypersensitivity to any component of the drug, especially to fluconazole.
• The drug is contraindicated in organic diseases of the central nervous system.
• Hypersensitivity to substances in the preparation, which are derivatives of nitroimidazole.
• The drug Dazel is contraindicated for use during pregnancy and lactation.
• Contraindicated in pathological changes in blood, especially in the anamnesis.

[9], [10]

Side effects Datum

Side effects Dazel can be caused by the reaction of the body to one of the components of the drug. Side effects include:

• Violation of the coordination of movement, ataxia, paresthesia, polyneuropathy.
• Dizziness and headache.
• Flatulence, unpleasant taste in the mouth.
• Diarrhea, abdominal pain.
• Vomiting and nausea.
• Neuropathy, leukopenia, thrombocytopenia.
• In patients with liver disease - severe manifestations of hepatotoxicity, as well as cholestatic jaundice.
• Skin rashes, dermatitis.
• Anaphylactoid reactions.
• Toxic epidermal necrosis.
• Angioedema.

[11]

Overdose

Overdose of the drug Dasel helps to enhance the above-described side effects and effects.

In case of overdose, seek medical attention and refuse to take the drug. Treatment provided - symptomatic.

[14], [15], [16],

Interactions with other drugs

Interaction Dazel with other drugs depends on the substances that are part of the drug complex.

• Fluconazole - when interacting with anticoagulants, an increase in prothrombin time is observed. Simultaneous use of patients with diabetes mellitus with hypoglycemic agents is possible only after the permission of the attending physician, since the probability of hypoglycemia is high. When interacting with rifampicin, the fluconazole elimination period is significantly reduced.
• Seknidazole - when interacting with anticoagulants, there may be an increased effect of the latter and even adverse reactions. When used with disulfiram, there is a high probability of psychosis and paranoid reactions. It is strictly prohibited interaction Dasel with nondepolarizing muscle relaxants. In the case of simultaneous use of Dasel with a lithium preparation, there is a high concentration of secnidazole in the blood plasma.
• Azithromycin - interaction with lekartsvennymi drugs ergot can cause ergotism. And with the simultaneous use of azithromycin with cyclosporine, the risk of toxic and adverse reactions of the drug increases, and azithromycin interferes with the metabolism of cyclosporine azithromycin.

[17], [18], [19], [20]

Storage conditions

The storage conditions of Dazel must fully comply with the recommendations that are prescribed in the instructions to the drug.

• Keep the drug at a temperature of 15C - 30 C.
• Keep the drug from direct sunlight.
• Keep away from children.

[21], [22]

Special instructions

Dazel is a universal medicinal complex that exerts on the body a multifaceted antibacterial and anti-infectious effect. Before buying a drug, consult your doctor and get permission to use Dasel. The drug is dispensed only by prescription.

Shelf life

Shelf life of the drug Dazel is three years from the date of production, which is indicated on the package. After the expiration date, the drug must be disposed of and not taken.

The use of an expired medication can lead to irreversible consequences. Before taking the drug complex Dazel, be sure to pay attention to the expiration date.