Glutargin

Glutargin is a hepatoprotective agent designed to protect and maintain liver function. The main active ingredient in Glutargin is arginine glutamate.

Arginine glutamate is a combination of two amino acids: arginine and glutamate. Both of these substances play an important role in the body. Arginine helps remove toxins from the liver, improves blood circulation and accelerates the regeneration of liver cells. Glutamate, in turn, is an important component of many metabolic processes, including in the liver.

Glutargin is commonly used to prevent and treat various liver diseases, such as fatty degeneration, hepatitis, cirrhosis, and others. It helps improve liver metabolism, reduce toxic levels, and promote liver recovery and protection from harmful factors.

Indications Glutargina

1. Fatty liver degeneration (steatosis).
2. Chronic and acute forms of hepatitis of various etiologies.
3. Liver cirrhosis.
4. Toxic liver damage caused by exposure to alcohol, drugs, chemicals and other factors.
5. Prevention and treatment of intestinal dysbiosis.
6. Liver restoration after surgery and radiation therapy.

Release form

Glutargin is usually produced in the form of a solution for intravenous administration. It can be supplied in ampoules or vials of various sizes, usually in concentrations of arginine glutamate 100 mg/ml or 500 mg/ml.

Pharmacodynamics

1. Amino acid metabolite: Arginine glutamate is a metabolite that is involved in various metabolic processes in the body. It plays an important role in amino acid metabolism, energy metabolism and other metabolic pathways.
2. Liver Support: Glutargin helps protect and restore liver function through its complex action. It may help reduce inflammation, stimulate liver cell regeneration, and protect them from damage.
3. Antioxidant effect: Arginine glutamate has antioxidant properties, helping to neutralize free radicals and protect liver cells from oxidative stress, which can be caused by various toxic substances or pathologies.
4. Stimulation of amino acid metabolism: Glutargin may help improve amino acid metabolism in the liver, which in turn can increase protein synthesis and improve overall liver health.
5. Improved metabolic functions: Glutargin may help improve the metabolic functions of the liver, including the processing and utilization of fats, carbohydrates and other nutrients.
6. Protection against toxic influences: Glutargin can help protect the liver from various toxic influences, such as alcohol, drugs, heavy metals and other substances.

Pharmacokinetics

1. Absorption: Arginine glutamate is generally well absorbed from the gastrointestinal tract after oral administration. It can quickly and easily penetrate the intestinal wall due to its low molecular weight.
2. Distribution: After absorption, arginine glutamate is distributed throughout the body through the blood. It can penetrate the blood-brain barrier and provide the desired effect in cells and tissues.
3. Metabolism: Arginine glutamate can be metabolized in the body through various metabolic pathways, including hydrolysis, oxidation and amidation. Metabolites can be formed and then excreted through the kidneys or biliary tract.
4. Excretion: Most metabolites of arginine glutamate are excreted from the body through the kidneys in the urine or through the biliary tract in the feces.

Dosing and administration

The hepatoprotective agent Glutargin, containing arginine glutamate, is usually used in the form of intravenous injections. Dosage may vary depending on the patient's condition, disease characteristics, and physician recommendations. It is usually recommended to use 5-20 ml of Glutargin solution per day, administered intravenously slowly, by dropper.

The exact dosage and treatment regimen should be determined by the doctor individually in accordance with the clinical picture and characteristics of the patient.

Use Glutargina during pregnancy

Glutargine, which contains arginine glutamate, is generally not recommended for use during pregnancy without consulting a doctor. Information on its safety during pregnancy may be limited, and potential risks to the baby may not be well understood.

Contraindications

1. Known allergic reaction: Patients with a known allergy to arginine glutamate or other components of the drug should avoid its use.
2. Severe renal and hepatic impairment: The use of Glutargin may be contraindicated in patients with severe renal and hepatic impairment, as this may lead to accumulation of the drug in the body and worsening of the condition.
3. Amino acid metabolic disorders: In patients with rare hereditary disorders of amino acid metabolism (for example, arginine glutamate), the use of Glutargin may be contraindicated and requires caution under medical supervision.
4. Pregnancy and breastfeeding: Data on the safety of Glutargin during pregnancy and breastfeeding are limited, so its use requires consultation with a doctor.
5. Children and adolescents: Data on the safety and effectiveness of Glutargin in children and adolescents may be limited, so its use in this category of patients requires special caution and medical supervision.

Side effects Glutargina

1. Allergic reactions such as itching, rash, redness of the skin and even anaphylactic shock rarely occur in persons with hypersensitivity to the components of the drug.
2. In rare cases, dyspeptic disorders (vomiting, diarrhea, nausea, abdominal pain) may occur.
3. You may experience an unpleasant taste in your mouth.
4. Increased blood ammonium levels (hyperammonemia) in some patients with absolute deficiency of one of the urea cycle enzymes.
5. Hyperazotemia may occur with high doses.
6. Increased stomach acidity may occur.
7. Rarely, blood disorders may occur.

Overdose

1. Gastrointestinal disorders: Diarrhea, nausea, vomiting, bloating, or abdominal pain may occur.
2. Electrolyte imbalances: Excessive use of amino acid supplements can lead to electrolyte imbalances in the body, especially if sodium or potassium intake is high.
3. Increased blood ammonium: Arginine glutamate may increase blood ammonium levels, especially in the presence of disorders of amino acid metabolism or liver function.
4. Impaired acid-base balance: Disturbances in the acid-base balance of the body may occur.
5. Allergic reactions: Some people may have an allergic reaction to amino acids, including skin rash, itching, swelling, or anaphylactic shock.

Interactions with other drugs

Interactions of the hepatoprotective agent Glutargin with other drugs may be limited due to the lack of significant interaction data. However, given that Glutargin contains arginine glutamate, which is a naturally occurring amino acid compound, interactions may be minimal.

Storage conditions

Usually hepatoprotective drugs, including Glutargin, are stored in a dry place at room temperature (15°C to 25°C), away from direct sunlight and moisture. Storage conditions may vary slightly depending on the specific manufacturer and formulation of the drug, so it is recommended to refer to the instructions for use or packaging for specific information on storing Glutargin.