Pectolvan

Pectolvan is a complex medication with mucolytic and expectorant activity. It contains such elements as ambroxol hydrochloride and carbocisteine.

Ambroxol stimulates the activity of the ciliated epithelium and at the same time increases the production of surfactant inside the lungs. This leads to an improvement in the separation and excretion of sputum (increased mucociliary clearance). As a result of the development of this influence, as well as the activation of fluid secretion, coughing is noticeably weakened and mucus excretion is facilitated. [1]

Indications Pectolvan

It is used in the treatment of the chronic and active stage of pathologies affecting the respiratory tract, against the background of which difficult secreting, viscous sputum is formed: BA , RDS , pneumonia, chronic pulmonary obstruction and bronchiectasis.

It is prescribed for the development of complications after lung surgery, and in addition, before and after a bronchoscopy session, as well as during tracheostomy care.

It can be used in the treatment of inflammation affecting the middle ear and paranasal sinuses.

Release form

The drug is released in the form of syrup, inside 0.1 liter bottles.

Pharmacodynamics

Due to the influence of carbocisteine, the viscosity of intrabronchial secretions decreases - by the destruction of disulfide compounds of glycoproteins. As a result of dilution of secretions, sputum is excreted much better. [2]

Pharmacokinetics

After oral administration, Ambroxol is almost completely absorbed inside the gastrointestinal tract, without complications passing into the tissues of the lungs. The level of absolute bioavailability of the substance is approximately 80%.

Plasma values Cmax of ambroxol are recorded after 2 hours from the moment of application, and the half-life is 8-12 hours. [3]

Ambroxol is excreted mainly in the urine (90%). The substance does not accumulate; overcomes the BBB and is excreted in breast milk.

After oral administration of carbocisteine, it is absorbed at a high rate, reaching the plasma level Cmax after 2 hours. Its weak bioavailability (below 10%) is noted, associated with intensive metabolic processes within the digestive system and the 1st intrahepatic passage.

The substance is excreted in the urine, mainly in the form of inactive metabolic elements (inorganic sulfates and diacetylcystine). A small remainder of the element is excreted unchanged in the feces. Carbocisteine can accumulate within the amniotic fluid as well as cross the placenta.

Dosing and administration

Children 7-12 years of age take 1 spoon (5 ml) of syrup 2-3 times a day. Children of the age group 2-6 years old - 0.5 tablespoons (2.5 ml), 2-3 times a day. For children over 1 month old and up to 2 years old, it is required to consume 0.5 tablespoons of syrup 2 times a day. The treatment cycle often lasts no more than 8-10 days.

Use Pectolvan during pregnancy

You can not use the medicine in the 1st trimester. The appointment in the 2nd and 3rd trimesters is allowed after a careful assessment of the likely benefits and risks to the fetus.

Due to the fact that the medication is excreted in breast milk, it cannot be used with breastfeeding.

Contraindications

The main contraindications:

• peptic type of ulcer in the gastrointestinal tract;
• convulsive syndrome;
• active phase of chronic glomerulonephritis;
• strong personal intolerance associated with the elements of the drug.

Side effects Pectolvan

Usually Pectolvan is tolerated without complications, but occasionally it can cause epidermal rashes and systemic weakness.

Prolonged administration of the drug can provoke disorders associated with digestive function: vomiting, gastralgia, nausea, diarrhea and heartburn. Occasionally bleeding occurs in the gastrointestinal tract.

Quincke's edema, urticaria, epidermal rash, and anaphylactic symptoms may occur. Severe epidermal disorders (SJS or TEN) develop occasionally.

A single long-term intake of Pectolvan causes headaches, palpitations and dizziness.

Overdose

Intoxication with Pectolvan can provoke the onset of nausea with vomiting.

When these disorders appear, symptomatic and supportive actions are taken.

Interactions with other drugs

The introduction of the drug together with GCS and antibacterial substances enhances their therapeutic effect in the treatment of inflammation that affects the respiratory tract.

The medicine cannot be combined with tetracyclines (excluding doxycycline); it is necessary to observe at least a 2-hour break between their introduction.

It is forbidden to combine with antitussive drugs (suppression of the activity of the cough center can provoke the accumulation of bronchial secretions inside the respiratory tract).

Storage conditions

Pectolvan must be stored in a dark and dry place, at temperatures in the range of 15-25 ° C.

Shelf life

Pectolvan can be applied within an 18-month term from the date of manufacture of the therapeutic agent.

Analogs

Medicines Mukosol and Milistan for cough are analogs of drugs.