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Alka-herbiter
Last reviewed: 23.04.2024
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Alka-Seltzer is a complex medicine.
Aspirin helps inactivate the COX enzyme, destroying the processes of binding prostacyclin to PG and thromboxane, and with it the production of ATP. It also demonstrates anti-inflammatory, analgesic and antipyretic effects and slows down platelet gluing.
Na bicarbonate neutralizes the effect of free gastric hydrochloric acid, making it possible to reduce the likelihood of the development of ulcerogenic effects of aspirin. Its antipyretic and analgesic effects develop quite quickly - because the drug is absorbed at high speed.
Indications Alka-seltzer
It is applied in case of such violations:
- arthritis of rheumatoid nature, rheumatism, as well as myocarditis, having an infectious-allergic origin;
- a feverish state that develops during infectious-inflammatory pathologies;
- pains of various origins: tooth or headache (also caused by alcohol withdrawal), myalgia, migraine, algomenorrhea, neuralgia and arthralgia;
- prevention of thromboembolism or thrombosis;
- secondary prevention of myocardial infarction.
[Release form
The release of the drug element is realized in soluble tablets - 10, 20 or 40 pieces inside the pack.
Pharmacokinetics
When used orally, aspirin is fully absorbed at high speed inside the gastrointestinal tract. In the process of absorption and after it, aspirin is transformed into its main metabolic component, which has medicinal activity - salicylic acid. Indicators of intraplasma Cmax aspirin are observed after 10-20 minutes; for salicylic acid, this value is 0.3-2 hours.
Aspirin with salicylic acid is substantially synthesized with intraplasma protein, distributed at high speed inside the body. Salicylic acid overcomes the placenta and is excreted in human milk.
The excretion of phenolic acid with its metabolic elements is realized mainly through the kidneys. Among the degradation products of the substance are salicylacyl and salicylphenol glucuronide, salicyl uric and gentisin uric acid, as well as gentisic acid.
The rate of excretion of phenolic acid depends on the size of the portion, because its exchange processes are limited by the properties of hepatic enzymes. Because of this, the term half-life varies in the range of 2-3 hours in the case of the introduction of small dosages and increases to almost 15 hours in the case of receiving large portions.
Na bicarbonate with citric acid is not subjected to absorption.
Dosing and administration
The drug is taken orally. For an adult, a 1-fold serving is 1-2 tablets (a maximum of 8 such tablets can be taken per day). The child needs to apply 0.5-1.5 tablets per 1-fold admission (per day, enter no more than 4 tablets).
Application for children
Persons younger than 14 years with diseases that cause hyperthermia, the medication is made only in the absence of effect from the use of other drugs.
Use Alka-seltzer during pregnancy
It is necessary to take into account that the introduction of large doses of salicylates in the first trimester in many epidemiological tests associated with a high probability of anomalies (for example, heart defects or cleft palate). But when using standard servings such a risk is probably quite low - because when testing conducted with approximately 3200 women, there was no increase in the percentage of anomalies.
In the 3rd trimester, the use of salicylates can provoke prolongation of gestation time and weakening labor contractions during childbirth. The woman and the fetus had an increased tendency to bleed. In the case of Alka-Seltzer, shortly before birth, newborn babies (especially premature babies) may develop bleeding inside the skull.
In the case of using standard doses of the drug, it is usually not necessary to stop breastfeeding during therapy. If continuous use of large dosages of drugs is required, a decision should be made to cancel HB.
Contraindications
It is forbidden to prescribe Na salicylate and Alka-Seltzer if the patient has ulcers or bleeding in the gastrointestinal tract.
It can not be used in the presence of ulcers in history, venous stasis (due to the weakening of the stability of the gastric mucosa) or portal hypertension, and besides this in a coagulant disorder.
Long-term use of salicylates can cause anemia; Because of this, it is required to regularly take blood tests, as well as to monitor the appearance of blood in the feces.
Because of the risk of signs of allergy, it is necessary to use the drug very carefully (and other salicylates) in people with severe intolerance to penicillins and other allergenic medicines.
Severe intolerance against Alka-Seltzer can lead to the emergence of "aspirin" asthma (to prevent its development, or to treat an existing disorder, special desensitizing procedures can).
In people with allergic pathologies, including asthma, hay and allergic rhinitis, epidermal itching, urticaria, nasal polyps and edema of mucous membranes, or in combination with infections of the respiratory tract (chronic), and besides, for people with intolerance regarding antirheumatic and analgesic substances Aspirin asthma may occur.
Without medical control, medication is used only in standard portions and for only a few days.
Side effects Alka-seltzer
Drug administration can provoke profuse sweating, hearing loss and ear noise, and, in addition, angioedema, epidermal and other allergy symptoms.
It is necessary to take into account that prolonged use of drugs without observation of the doctor can lead to the appearance of bleeding inside the stomach and dyspeptic disorders; in addition to this, damage to the mucous membrane of the entire gastrointestinal tract may occur.
To weaken the ulcerogenic effect and prevent the appearance of bleeding inside the stomach, you need to use the medication only after a meal; at the same time, the tablets should be well crushed and washed down with a large volume of liquid (it is recommended to drink milk). But there is also information that bleeding appears in the case of the use of drugs after eating. To reduce the irritating effect on the stomach, you can take alkaline mineral water after the preparation or a solution of sodium bicarbonate.
Because of the effect on platelet bonding, and in addition to this existing anticoagulant effect, blood tests must be performed at times during therapy. People with circulatory disorders (especially hemophilia) may experience bleeding. To identify ulcerogenic activity at the initial stage, it is necessary to occasionally check feces for the presence of blood in them.
Overdose
Mild poisoning leads to the development of vomiting, pain in the epigastric zone, nausea, and in addition (especially in elderly people and children) headaches, ear noise and dizziness, as well as weakening of hearing and vision.
Severe intoxication causes drowsiness, tremor, incoherence of thinking, suffocation, collapse and confusion, and in addition dyspnea, hyperthermia, respiratory alkalosis, dehydration, coma, acidosis of the metabolic form, disorder of carbohydrate metabolism and alkaline urine response.
Lethal dosage of medication for an adult - more than 10 g; for a child - more than 3 years
In case of overdose, taking into account the indicators of acid-base and salt balance, the introduction of liquids of sodium bicarbonate, Na lactate or citrate is performed.
Interactions with other drugs
Combining the drug with anticoagulants increases the likelihood of bleeding.
The combination of drugs with NSAIDs leads to a potentiation of the negative effects and the main effect of the latter.
When Alka-Seltzer is used, there is an increase in the negative effect of methotrexate.
The introduction of the drug together with ingested hypoglycemic substances (sulfonylurea derivatives) causes potentiation of antidiabetic activity.
The combination of drugs and corticosteroids increases the likelihood of a patient bleeding in the gastrointestinal tract.
Aspirin reduces the therapeutic effect of furosemide, spironolactone, antihypertensive drugs and anti-gouty substances that help to excrete uric acid.
Storage conditions
Alka-Seltzer must be kept in a place that is protected from the entry of small children. Temperature indicators - not more than 25 ° С.
Shelf life
Alka-Seltzer can be used within the 36-month term since the sale of the drug.
Analogs
Analogs of drugs are substances Ascelisin, Aspirin with Alka-prima, Asprovit, Askofen with Antigriocaps, and in addition, Aspicod and Acecardin with Aspeter, Onofrol and Citropack. Also included in the list are Polokard, Copacil, Citramon with Migralgin, Farmadol and Upsarin.
Attention!
To simplify the perception of information, this instruction for use of the drug "Alka-herbiter" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.