Lerivon

Lerivon is a tetracyclic that is part of the piperazine-azepine antidepressants group.

The drug helps to block α2-adrenoreceptors, and in addition it increases the performance of a norepinephrine mediator inside the synapse gap. Potentiated noradrenergic transmission of neural impulses helps to increase brain activity. It is in this way that the anxiolytic influence exerted by the therapeutic agent is mediated.

Activation of α-adreno-, as well as H1-histamine endings leads to the development of an intense sedative effect of drugs.

[1]

Indications Lerivona

It is used for depression, having a diverse nature.

Release form

The release of the medicinal substance is implemented in tablets, 20 pieces in each cell plate.

[2]

Dosing and administration

It is necessary to use a medication orally, without chewing a pill, washing it down with plain water.

At the beginning of the course, an adult should take 30 mg of the substance. Taking into account the clinical effect, correction of the portion is performed. The size of the maintenance dosage should be lower than the initial one. During the day, you can enter a maximum of 60-90 mg of the drug.

Older people are first prescribed a similar portion of the drug. In order for medical effects to occur, lower dosages are required; their titration is performed by the attending doctor during the course of the treatment cycle.

It is recommended to use Lerivon in the evening, before going to bed, because it has a strong sedative effect.

The average therapeutic course lasts 4-6 months. Antidepressant treatment is continued for several more months after the improvement of the clinical picture. It is forbidden to abruptly cancel the use of drugs, because it increases the likelihood of withdrawal.

[3]

Use Lerivona during pregnancy

There is only limited information regarding the safety of using drugs during lactation or pregnancy. Before prescribing Lerivon, a doctor should evaluate all possible risks and benefits of his admission.

Contraindications

Among the contraindications:

• manic syndrome;
• an appointment for treatment of depression in persons with a strong impairment of the liver, because the drug may accumulate, which can lead to intoxication;
• the appointment of people diagnosed with intolerance against the elements of the drug.

Side effects Lerivona

Often, among the side effects, there are disorders associated with the work of the central nervous system: convulsive readiness accompanied by hyperkinetic syndrome, and in addition hypomania and MNS.

At the initial stage of administering the medication, there may be a tendency to develop a variety of arrhythmias or bradycardia.

Due to the pharmacokinetics of drugs, jaundice can sometimes develop or the activity of the action of intrahepatic enzymes may increase.

Granulocytopenia or agranulocytosis may also occur.

In some people, the appearance of an allergic rash or the development of arthralgia was observed.

Overdose

With drug poisoning, prolonged sedation is noted. More rarely, hypotension, cardiac rhythm disorders, convulsive readiness, and breathing problems occur.

The medicine has no antidote. In case of overdose, symptomatic, supporting and detoxifying actions are performed (this includes gastric lavage in the first few hours after drinking the drug). If severe disorders of vital activity are noted, this parameter is constantly monitored.

Interactions with other drugs

The drug enhances the effect of IMAO, so they are not used for at least 14 days from the end of treatment with the use of tricyclics.

The drug contributes to the violation of metabolic processes of coagulants of indirect type of influence, because of which, when combined, it is necessary to regularly monitor the function of the clotting system.

Lerivon does not affect the pharmacokinetic characteristics of antihypertensive agents (clonidine and hydralazine with guanethidine, and in addition to betanidin and methyldopa with propranolol).

Alcoholic beverages potentiate the slowing effect of the drug in relation to the central nervous system, because of what patients need to abandon their use during therapy.

[4], [5], [6]

Storage conditions

Lerivon is required to be maintained at a temperature in the range of 2-30 ° C.

Shelf life

Lerivon can be used within a 5-year term from the date of implementation of the therapeutic substance.

Application for children

You can not prescribe the drug in pediatrics.

[7], [8]

Analogs

Analogs of drugs are the means Melitor, Alventa, Deprexor and Velaksin with Intriv, and besides this Venlaksor, Mirzaten, Medofaxin and Depresil with Mirazep. In addition, Coaxil, Mirtazapine, Normazidol and Mirtel with Life 600/900, as well as Mirtstadin with Mianserin, Trittico, Remeron with Miaser, Espirtal and Mirtel with Simbalta and Neuroplan with Eliphor are on the list.

[9],

Reviews

Lerivon receives quite different reviews from patients, so we can conclude that his influence is individual in nature. Sometimes his admission leads to the appearance of negative symptoms, overlapping the benefits of the treatment being given, because of which patients should very carefully monitor any changes in their condition and immediately report them to their doctor.