With Lerma

Lerkamen has an intense antihypertensive effect. The principle of action of the drug is based on the selective blocking of the activity of calcium endings. The lercanidipine component can inhibit the movement of calcium ions inside the smooth muscle tissue with cardiomyocytes.

The drug weakens the systemic resistance of peripheral vessels, and with it gradually expands their lumen, preventing the appearance of collapse and reflex tachycardia. The drug does not have a negative inotropic effect.

Indications Lerkamena

It is used in case of development of primary hypertension, having a moderate or light degree of intensity.

Release form

The release of drugs produced in the form of tablets with a volume of 10 or 20 mg. Inside the blister pack contains 7 or 10 tablets.

[1], [2]

Pharmacokinetics

The drug is well absorbed inside the digestive tract. The Cmax values inside the plasma are noted after 1.5-3 hours. About 98% of the active component is synthesized with the intra plasma protein.

The bioavailability of drugs increases after eating food, because of what you need to take medicine on an empty stomach. An increase in the level of bioavailability is also observed in the case of increasing the dosage.

The metabolism of the drug takes place inside the liver, because of what it has a weak absolute bioavailability - only 10%.

The antihypertensive effect of Lerkamena has been observed for 24 hours. The active element is excreted by the kidneys; half-life term is 10 hours.

[3], [4], [5],

Dosing and administration

The medication is taken orally. You can not damage the shell of the tablet or crush it. In the case of taking the drug on an empty stomach, its therapeutic efficacy increases. The duration of treatment is selected by the doctor.

It is necessary to use medicine in a portion of 10 mg, 1-time in a day. If after 2 weeks of this application, blood pressure indicators do not decrease, you can proceed to receive 1-fold dosage of 20 mg.

The drug is taken on an empty stomach, washing down the tablets with plain water. Exceeding the daily dose of 20 mg does not lead to potentiation of the antihypertensive effect, but causes an increase in the intensity and frequency of the development of adverse negative symptoms.

If Lerkamen does not help reduce elevated blood pressure, it is necessary to use additional antihypertensive agents from other medical groups.

[10], [11], [12]

Use Lerkamena during pregnancy

You can not prescribe the drug during breastfeeding or pregnancy.

Contraindications

The main contraindications:

• obstruction of the left ventricular vessels;
• SN;
• personal intolerance associated with lercanidipine;
• lactose intolerance;
• unstable angina;
• myocardial infarction in the active phase;
• the presence of SSS (in persons who do not use a pacemaker).

[6], [7], [8], [9]

Side effects Lerkamena

Among the side effects:

• problems associated with the work of NA: dizziness, migraine and disorders of the daily regimen;
• disorders affecting the digestive function: gastralgia, problems with food digestion, stool disorders, increased AST values with ALT and dyspepsia (nausea with vomiting);
• CVD lesions: discomfort or pain in the chest zone, increased heart rate, decreased blood pressure and increased angina pectoris attacks;
• Other symptoms: allergies, polyuria, hyperemia, increased urination, swelling, muscle aches and gum hyperplasia.

Overdose

During intoxication, drowsiness, nausea, a decrease in blood pressure values, ischemic changes affecting myocardial tissues, as well as cardiogenic shock are observed. In such situations, it is necessary to induce vomiting and give the patient enterosorbents with laxatives.

Severe poisoning requires the use of catecholamines, dopamine and diuretic substances. In the case of a decrease in blood pressure, bradycardia and loss of consciousness, atropine may be administered. Therapy is performed at the hospital. Hemodialysis sessions will be ineffective.

[13], [14]

Interactions with other drugs

Lerkamena suction is potentiated when midazolam is used.

Substances inducing the action of CYP3A4, cyclosporine with ethyl alcohol, as well as grapefruit juice can not be used during drug administration.

It is extremely necessary to apply the drug in combination with large portions of cimetidine (over 0.8 g).

Indicators of bioavailability of the active component of drugs increase with the potentiation of negative inotropic effects in the case of the introduction of β-blockers.

After the start of lerkandipina application, it is necessary to change the dosage of digoxin.

In order to reduce the likelihood of adverse effects in the interaction, one should adhere to a 10-hour break between the administration of simvastatin and Lerkamena.

[15]

Storage conditions

Lerkamen should be kept at a temperature not exceeding 25 ° C.

[16], [17], [18], [19], [20], [21]

Shelf life

Lerkamen can be used within a 36-month term from the time a pharmaceutical product is released.

[22]

Application for children

Not used in pediatrics (persons under 18 years of age).

[23]

Analogs

Analogs of drugs are substances Zanidip Recordati, Levervas and Lerkaton with Zanikor.

[24], [25]

Reviews

Lerkamen receives extremely positive reviews from patients on medical sites and forums. The drug helps stabilize blood pressure indicators after 14 days of its continuous intake (for people with hypertension of 1st degree). At the same time, it is noted that adverse signs develop quite rarely, and when combined with other antihypertensive drugs, the medication is also effective in the case of hypertension, which has a 2–3 degree of intensity.

[26]