Gepaforte

Hepaforte is used for liver diseases. It is a lipotropic agent.

The phospholipids contained in the drug are similar in chemical structure to the internal human phospholipids, but they are superior because they contain more polyunsaturated fatty acids. These molecules are mainly embedded inside the structures of cell walls and simplify the process of restoring damaged hepatic tissues.

Indications Gepaforte

Used for such disorders:

• hepatic fatty degeneration;
• hepatitis in the active or chronic phase;
• hepatic cirrhosis ;
• psoriasis;
• pre- or postoperative therapy in people who underwent surgery in the area of the liver or the liver;
• hepatic intoxication;
• toxicosis developing during pregnancy;
• radiation poisoning.

Release form

The release of drugs is carried out in capsules - 10 pieces inside the cell plate. In a pack - 3 such records.

Pharmacodynamics

In case of damage to the liver cells by the action of alcohol, viruses, and toxic components, phospholipids help develop a hepatoprotective effect. Inside the cells, the rate of receipt and excretion of elements increases, as well as improvement of hepatic metabolic processes and restoration of enzyme systems.

Phospholipids regulate lipoprotein metabolism, thereby affecting the disturbed metabolism of fats. At the same time, cholesterol with neutral fats are transformed into forms that are suitable for movement (especially due to the increased ability of HDL to add cholesterol), and then subjected to subsequent oxidation. During the excretion of phospholipids through the HDV, the indices of the lithogenic index decrease, and also the stabilization of bile is carried out.

The complex of various vitamins has the following properties:

• niacinamide has lipid-lowering activity and prevents fatty hepatic transformation;
• pyridoxine, being a coenzyme, is involved in phospholipid, protein and amino acid metabolism;
• thiamine is a member of carbohydrate metabolism;
• Riboflavin is a cofactor for a large number of respiratory enzymes;
• tocopherol has an antioxidant effect on the cell walls and prevents the oxidation of unsaturated fatty acids.

Pharmacokinetics

After taking the drug inside, more than 90% of phospholipids are absorbed through the gastrointestinal tract.

Most of the drug is cleaved, forming the element 1 acyl-LIZO-phosphatidylcholine. At the same time, 50% of this element is still transformed inside the small intestine into phosphatidylcholine of a polyunsaturated nature. In the future, this component in combination with HDL moves into the liver. Plasma Cmax values of phospholipids are noted after 6 hours.

Metabolic processes take place inside the kidneys with the liver.

Excretion is mainly carried out with feces. A smaller part is excreted in the urine.

Dosing and administration

At first, Gepaphorte is consumed in portions 2 capsules 3 times a day. The size of the maintenance dosage is 1 capsule 3 times a day. Capsules washed down with a small amount of ordinary water, taking them with food.

Therapy lasts due to its effectiveness and the nature of the course of the disease. It usually lasts at least 90 days.

In the case of psoriasis, the therapeutic cycle lasts 14 days; The drug is used in combination with standard drugs used in the treatment of this pathology.

Use Gepaforte during pregnancy

The drug can be used for breastfeeding or pregnancy with a doctor's appointment.

Contraindications

The main contraindications:

• strong personal intolerance associated with the elements of the drug;
• gland bladder empyema;
• cholestasis or nephrolithiasis;
• ulcers in the gastrointestinal tract in the active phase of development.

Side effects Gepaforte

Basically, the drug is transferred without the development of complications. Only the following side effects are noted:

• nausea, gastric discomfort, dark yellow urine tinge, diarrhea and bloating;
• signs of intolerance, itching, epidermal rash and urticaria.

Overdose

Possible potentiation of side effects, as well as the appearance of vomiting, diarrhea and nausea. Prolonged administration in large portions may trigger the development of polyneuropathy.

Interactions with other drugs

It is necessary to take into account the presence of vitamins in the composition of the drug - to prevent possible intoxication with vitamins when using other multivitamin preparations.

Tocopherol acetate potentiates the activity of steroid drugs and NSAIDs (prednisone with diclofenac sodium, and ibuprofen). Therefore, this vitamin should not be combined with substances that demonstrate alkaline effects (trometamol or sodium bicarbonate), as well as with silver or iron medications and indirect anticoagulants (this includes neodicoumarin with dicoumarin).

Pyridoxine hydrochloride is able to reduce the effects of levodopa, as well as reduce the toxic signs arising from the use of isoniazid and other anti-tuberculosis substances. Vitamin also potentiates the effect exerted by diuretic substances. Penicillamine, isoniazid, as well as immunosuppressants, hydralazine with pyrazinamide and estrogens (among them estrogen-containing oral contraception) are pyridoxine antagonists or potentiate its excretion via the kidneys.

Riboflavin is not compatible with streptomycin, and in addition it weakens the effect of antibacterial agents (doxycycline, lincomycin with oxytetracycline, and tetracycline with erythromycin). Tricyclics and amitriptyline with imipramine slow down riboflavin metabolic processes. 

Thiamine can reduce curare-like effect. Antacids inhibit vitamin absorption. Inactivation of the effect of thiamine occurs under the action of 5-fluorouracil, because the latter demonstrates a competitive slowdown in the process of vitamin phosphorylation with the subsequent formation of thiamine pyrophosphate.

Because cholestyramine reduces the absorption of niacinamide, it is necessary to observe a 4-6 hour break between their injections.

Rifampicin weakens the binding of bilirubin and increases its protein synthesis.

Paracetamol reduces transaminase levels inside serum.

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Storage conditions

Gepaforte is required to be kept in a place closed from the infiltration of children. Temperature values - maximum 25 ° С.

Shelf life

Gepaforte can be used throughout the 24-month term from the moment of drug implementation.

Application for children

Gepaforte can be used in adolescents over 12 years of age.

Analogs

Analogues of drugs are drugs Hepatosan, Laennec, Prohepar, Maksar with Hepatocline, Liventiale with Orniliv, and in addition Hepaphor, Livolakt, Hepatrine with Lipoic acid and Dipana.