Diclobene

Dicloben contains the component diclofenac Na, which is a substance of NSAIDs, possessing analgesic activity. The medicine is used locally. Its medicinal effect is provided by the retarding effect that the active element of the drug has on the processes of binding of PG.

After local use, the active component of the drug passes through the epidermis, reaching the subcutaneous layer. In this area, it demonstrates anti-inflammatory and analgesic activity, and at the same time reduces tissue swelling.

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Indications Diclobene

It is used for local relief of pain that develops in the case of acute injuries of a traumatic nature (including sports injuries, such as bruises, sprains or dislocations).

It is also prescribed for symptomatic procedures for localized lesions in the area of soft tissue joints of rheumatic origin.

Release form

The drug is released in the form of a transdermal patch - 5 pieces inside a sealed bag; the pack contains 1 or 2 such bags.

Pharmacodynamics

After using Dicloben in people with severe sports injuries, the drug showed a highly effective analgesic effect compared to the placebo group.

Tissue levels of diclofenac are maintained at a therapeutic level by continuous passage from the medicated patch, regardless of the time of day. Average plasma levels of the substance are about 3 ng/ml.

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Pharmacokinetics

Metabolic processes and excretion of diclofenac with its local use are similar to the parameters noted after taking diclofenac Na orally. The half-life is 1-2 hours.

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Dosing and administration

The patch must be applied to the affected area of the body. Two patches are used per day (applied in the morning and in the evening). Before applying, the protective film must be removed from the patch. One medicinal patch is intended for continuous use for 12 hours.

No more than 2 patches can be used per day, even if there is a need to use them in more than one area. Only one damaged area can be treated at a time.

If necessary, a special mesh elastic bandage can be used to hold the patch in place.

It is necessary to use Dicloben for the minimum required period. The duration of treatment should be a maximum of 1 week. The decision regarding the continuation of the course is made by the attending physician, personally.

Use Diclobene during pregnancy

There is insufficient clinical data on topical use of diclofenac in the 1st and 2nd trimesters. Animal testing has demonstrated the development of reproductive toxicity with systemic administration of the drug.

Since it was not possible to establish the consequences of the impact of the processes of slowing down the biosynthesis of PG on pregnancy, in the 1st and 2nd trimesters, Dicloben is used only with the doctor’s prescription, taking into account the higher probability of the usefulness of the drug.

The drug cannot be used in the 3rd trimester, because substances that slow down the binding of PG can provoke the following disorders:

• the fetus may develop cardiopulmonary toxicity (premature closure of arterial ducts and development of pulmonary hypertension);
• the fetus may also experience impaired renal function, progressing to the development of failure, accompanied by oligohydramnios;
• a pregnant woman may experience prolonged bleeding associated with a slowdown in platelet aggregation, which occurs even when using extremely low doses of the drug;
• Also, a pregnant woman may experience slower contractions of the uterine muscles, which can prolong or delay the labor process.

A small portion of diclofenac with its metabolic components passes into the mother's milk. The drug can be used during lactation only with the permission of a doctor, in situations where the benefit from it is more likely than the possibility of complications. It is prohibited to treat the mammary glands or large areas of the body with the drug, as well as to use it for a long period of time.

Contraindications

Main contraindications:

• severe intolerance to aspirin, diclofenac, other NSAIDs, as well as analgesics or other components of the drug;
• presence of attacks of asthma, acute rhinitis or urticaria associated with the use of aspirin or other NSAIDs (in the anamnesis);
• active phase of ulcer in the gastrointestinal tract;
• burns or open epidermal lesions;
• eczema or skin infections.

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Side effects Diclobene

Side effects related to the subcutaneous layers and epidermis: itching, rash, redness and burning, sometimes accompanied by blisters or pustules. In addition, local signs of allergy may appear, including contact dermatitis in people who have undergone external treatment with NSAIDs, and intolerance symptoms. Signs such as anaphylactic reactions, angioedema and photosensitivity are also noted, as well as generalized epidermal rash.

Treatment of large body surfaces over a long period of time may cause the development of systemic adverse effects (for example, gastrointestinal or kidney diseases and bronchial spasms), but the likelihood of their occurrence is extremely low compared to taking diclofenac Na orally.

Storage conditions

Diclobene should be stored in a dark place, out of the reach of small children. Temperature indicators should not exceed 25°C.

Shelf life

Dicloben can be used for a period of 30 months from the date of manufacture of the medicine. Opened packaging has a 4-month shelf life.

Application for children

There is no information regarding the safety and medicinal efficacy of the drug when used in pediatrics (under 18 years of age).

Analogues

The analogs of the drug are the substances Butadion, Dolgit, Diclofen with Valusal, Ketoprofen and Remisid with Veral, and in addition to this Ketoprom, Diclomec with Neofen, Diclosan and Klafen. Also on the list are Diclofenac, Revmalin, Nimid with Dimetsin, Ketosprey and Fort-gel, Ibalgin with Ultrafastin, Ketum-gel and Finalgel, Naproxen with Cinepar active, as well as Nobi gel, F-gel, Nortafen and Fastum gel with Fanigan fast.

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