Viagra

Viagra helps restore a healthy response to sexual arousal. The physiological process, which leads to an erection, is carried out with the secretion of nitric oxide inside the cavernous body, resulting from sexual stimulation.

NO stimulates the activity of a special enzyme called guanylate cyclase. This leads to an increase in the cGMP element. Muscle relaxation of the cavernous body and potentiation of blood circulation inside the penis also occur.

Indications Viagra

It is used in the case of the development of a variety of erectile disorders (usually they are organic, psychogenic or mixed).

[1], [2], [3]

Release form

The release of the drug substance is produced in tablets.

[4], [5]

Pharmacodynamics

Sildenafil is an active component of the drug; it is a selective inhibitor of the PDE-5 component, which ensures the processes of decomposition of the cGMP element inside the cavernous body. The drug has a peripheral effect on erection of the penis. It should be borne in mind that sildenafil does not have a direct relaxing effect on the cavernous body, but affects the relaxing activity of nitric oxide. In order for the medicine to begin to act, a man must experience sexual arousal.

The drug is transferred without complications; volunteers did not experience significant clinical deviations with a single dose of no more than 0.1 g.

[6], [7]

Dosing and administration

The medication is taken orally, approximately 60 minutes before the expected onset of sexual intercourse. For the day required to use 50 mg of the substance (1-fold). Taking into account the personal tolerance and effectiveness of the drug, the dosage can be reduced to 25 mg or increased to 0.1 g. A maximum of 0.1 g of the substance is allowed per day.

[10]

Use Viagra during pregnancy

Viagra is used only in men.

Contraindications

The main contraindications:

• severe intolerance to medication elements;
• the presence of anatomical deformations of the penis (for example, cavernous fibrosis, Peyronie's disease or angulation);
• strong tendency to bleed;
• ulcers in the gastrointestinal tract in the active phase;
• problems with liver function (especially the lack of its work or cirrhosis);
• diseases leading to priapism (among them myeloma, leukemia, or sickle-cell anemia);
• increased or decreased blood pressure (severe intensity);
• various heart diseases (a dangerous kind of arrhythmia, unstable angina or CHF).

In the next six months after myocardial infarction or stroke, Viagra is prohibited. You also can not prescribe medication in combination with nitric oxide donors and nitrates. In addition, the drug is not used in men who are prohibited sexual activity.

Side effects Viagra

The drug is often tolerated without the development of complications. Only sometimes such side effects appear:

• disorders of the central nervous system: dizziness, insomnia or increased muscle tone;
• disorders of the CVS function: headaches, hot flashes or dilation of blood vessels;
• ODA lesions: pains affecting muscles and joints;
• problems with the activity of the gastrointestinal tract: diarrhea, dyspepsia or nausea;
• epidermal disorders: rash;
• symptoms associated with the senses: visual disturbance, color distortion, increased light perception and conjunctivitis;
• respiratory tract infections: pharyngitis, infections in the respiratory tract, sinusitis, respiratory disorders, nasal congestion and runny nose;
• disorders of urogenital function: problems with the activity of the prostate and urinary duct infections;
• other disorders: pain in the abdomen or back area and flu manifestations. Occasionally, priapism is noted.

[8], [9]

Overdose

Tests have demonstrated that Viagra intoxication causes increased severity of side effects.

When such violations are required to carry out symptomatic measures. Dialysis will be ineffective, because the active element of the drug at high speed and is very actively synthesized with the protein of blood plasma.

Interactions with other drugs

Cimetidine, erythromycin, and ketoconazole lower the clearance of the drug with a further increase in the plasma level of sildenafil.

The combination of Viagra with Na nitroprusside leads to the potentiation of its antiaggregant properties.

Use together with nitrates potentiates their antihypertensive activity. The result of such exposure may be even the death of the patient.

The combination of medication with inside anti-diabetic medicines, β-adrenergic blockers and BMCC is also dangerous for life.

[11], [12], [13], [14]

Storage conditions

Viagra should be stored in a closed place from small children and moisture penetration. The temperature level is maximum 30 ° C.

[15], [16]

Shelf life

Viagra can be used for a 24-month term from the time the drug was manufactured.

Application for children

The drug is not prescribed in pediatrics.

[17]

Analogs

Analogues of the drug are substances Genagra, Vekta and Potential with Penimex.

[18], [19], [20], [21]

Reviews

Viagra receives a large number of reviews from men of different ages. It is believed that the drug is highly effective, contributing to the improvement of sexual function. The downside is only that this medicine is quite expensive.