Peak

Orgil ensures the development of a bactericidal and antiprotozoal effect.

The drug contains the active element ornidazole, which has DNA-tropic therapeutic activity. The drug is a derivative of 5-nitroimidazole.

The ornidazole component demonstrates the therapeutic effect on the simplest microbes (this includes Trichomonas with leishmania, Giardia, dysenteric amoebas and gardnerella with balantidia), in addition to this relatively gram-positive and -negative microorganisms.

Indications Orgila

It is used for therapy for giardiasis, amebiasis (its extraintestinal types and intestinal infections), as well as trichomoniasis.

Used to prevent the development of anaerobic infection in the case of gynecological operations.

[1],

Release form

The release of the drug is sold in tablets with a volume of 0.5 g, 10 pieces inside the box.

[2], [3]

Pharmacodynamics

After taking ornidazole, complete and rapid absorption of the substance from the gastrointestinal tract occurs (about 90%). Blood Cmax values are recorded after 3 hours. Intlasma synthesis with protein is negligible (approximately 13%). The drug goes well into any fluids with tissues.

The coefficient of accumulation in the case of taking drugs courses in portions of 0.5 g or after 12 hours is equal to 2.5. The metabolic processes are realized inside the liver; at the same time, hydroxymethyl and α-hydroxymethyl metbolic components are formed that have weaker medicinal activity against anaerobes and Trichomonas vaginal than the unchanged active element of drugs.

Excretion (mainly in the form of metabolic components) is carried out with urine. The term half-life is 13 hours.

[4], [5], [6], [7], [8], [9], [10], [11]

Dosing and administration

The medication is taken after a meal, washing down the tablets with plain water.

With trichomoniasis, use 1-well tablet (0.5 g) 2 times a day for a period of 5 days, or 3 tablets (1500 mg) 1 time, for the night. To get a more pronounced effect, you should additionally use vaginal suppositories. It is also necessary to undergo a medical course and a sexual partner of a woman.

In the case of giardiasis, use 3 tablets per day (1500 mg), for 1-2 days.

For amebiasis that affects the intestines, use 3 tablets 1-fold per day for a period of 3 days. In the case of an extraintestinal type of pathology, a 1-well tablet is used 2 times a day for a period of 5-10 days.

To prevent the occurrence of infections caused by anaerobes, after surgery, you can take 1-2 tablets of drugs 2 times a day for 3-4 days.

[17], [18], [19], [20], [21]

Use Orgila during pregnancy

It is forbidden to use Orgil during pregnancy.

Contraindications

The main contraindications:

• hypersensitivity to the drug;
• diseases affecting the central nervous system (epilepsy or multiple sclerosis);
• breast-feeding.

[12], [13], [14], [15]

Side effects Orgila

Among the side effects:

• dysfunction of the digestive tract and nausea;
• dizziness, fatigue, tremor, drowsiness, loss of consciousness, and besides headaches, neuropathy, coordination disorder, convulsions and symptoms of intolerance.

[16]

Overdose

In case of poisoning, convulsions, depression and neuritis of a peripheral nature are noted.

[22], [23], [24]

Interactions with other drugs

The drug potentiates the activity of coumarin anticoagulants, as well as the muscle relaxant effect of vecuronium bromide.

The combination with other substances that are derivatives of 5-nitroimidazole, leads to an increase in the likelihood of seizures similar to epileptic, neuropathy, as well as depression.

The drug can not be combined with alcoholic beverages.

Introduction together with rifampicin or barbiturates reduces the term half-life of ornidazole.

It is forbidden to use simultaneously with neurotoxic or hematotoxic substances.

[25], [26], [27], [28], [29]

Storage conditions

Orgyl must be maintained at temperature values not exceeding 25 ° C.

[30]

Shelf life

Orgyl can be used for a 3-year term since the release of the drug product.

[31]

Application for children

Do not appoint in pediatrics until 3 years of age.

[32]

Analogs

Analogues of the drug are the substances Ornigil, Meradazole, Ornidazole and Meratin with Ornisid, and in addition Orzol, Tiberal and Ornigil with Ornivag 500.

[33], [34], [35]

Reviews

Orgil receives positive reviews from most patients. The comments indicate that combination therapy with the use of medication allows you to completely eliminate infections associated with the urogenital tract.