Acupan

With the introduction of Akupan has a powerful and stable analgesic effect on the patient's body.

The main therapeutic effect of drugs is developed by significantly slowing down the processes of dopamine, noradrenaline and serotonin reuptake, which occur through synapses. The active element of this medication is the nefopam component. It possesses, among other things, m-anticholinergic drug activity that is not essential for the patient.

[1], [2]

Indications Acupan

It is used in case of development of pain of various origin and intensity - for such violations:

• after performing operations;
• injuries;
• myalgia ;
• elimination of pain during childbirth;
• toothache;
• colic in the area of the liver or kidneys and so on.

Release form

The release of drugs is implemented in the form of injection fluid, inside ampoules, 5 pieces inside a special pan.

[3]

Pharmacodynamics

Akupan is used to eliminate tremors that develop after operations. In addition, it is necessary to clarify that the drug does not have an antipyretic or anti-inflammatory effect, and also does not suppress the respiratory processes and does not affect the activity of intestinal peristalsis.

Pharmacokinetics

The use of the 1st portion leads to the achievement of the indices necessary for the beginning of the drug effect after 0.5-1 hour. Protein intraplasma synthesis is 71-76%. When metabolic processes are formed metabolic components, then excreted by the kidneys.

[4], [5], [6], [7],

Dosing and administration

During therapy it is very important to choose a portion that will correspond to the response of the patient and the severity of the pain that has appeared.

With intramuscular use of the drug injection should be as deep as possible. The size of 1-fold portion is equal to 20 mg. If necessary, the drug can be administered at 6-hour intervals. Per day, a maximum of 0.12 g of the substance is allowed.

Intravenous infusion procedures should be long - at least 15 minutes. During the infusion the patient should lie down. A single serving is equal to 20 mg. When the need arises, the medication can be applied at 4-hour intervals. During the day, you can use a maximum of 0.12 g of medication.

With the introduction of the drug can use standard infusion fluid - 5% dextrose or 0.9% NaCl.

It is recommended to use the drug in the proportion of 1 ampoule of substance per 50 ml of infusion fluid. The duration of treatment can be a maximum of 8-10 days.

Use Acupan during pregnancy

It is forbidden to appoint Acupan during pregnancy.

Contraindications

Among the contraindications:

• strong personal sensitivity regarding the drug;
• epilepsy or convulsions;
• the risk of urinary retention due to prostate or urethral disease;
• the likelihood of glaucoma in the acute phase;
• breast-feeding.

Caution is required when treating people with renal or hepatic impairment and tachycardia, as well as in the elderly.

[8], [9], [10]

Side effects Acupan

Among the side effects:

• vomiting with nausea;
• drowsiness, increased blood pressure, hyperhidrosis, hallucinations, tachycardia, atropine-like symptoms and convulsions;
• urticaria, anaphylaxis, intolerance and angioedema.

[11]

Overdose

With intoxication, hallucinations, convulsions and tachycardia occur.

Symptomatic medical measures are performed at the hospital, in which the respiratory and cardiac functions are controlled.

[12], [13], [14], [15], [16], [17], [18], [19]

Interactions with other drugs

Combination with m-anticholinergic drugs and sympathomimetics can cause potentiation of the negative signs of Acupana. Because of this, anti-depressants of an imipramine nature, atropine-like antispasmodics, disopyramide with m-cholinoblocking antiparkinsonian drugs, substances that block the activity of histamine H1 termini, and phenothiazine neuroleptics are not used with it.

[20], [21]

Storage conditions

Acupan should be kept in a dry and dark place, closed from the penetration of young children.

[22], [23]

Shelf life

Acupan can be used for a period of 3 years from the date the therapeutic agent is released.

[24]

Application for children

Cannot be used for children under 12 years old.

[25], [26], [27], [28]

Analogs

Analogs of drugs are the substances Nefopam, Cardiomagnyl with Oxadol, and Analgin, Paracetamol and Amizon.

[29]

Reviews

Akupan receives quite a few reviews, but in the existing comments it is noted that the drug has a high therapeutic efficacy. When used after surgery, it provides high-quality analgesic effect for almost 8 hours.

Some patients talk about the development of some adverse events with the administration of a drug, such as fever, problems with respiratory function and dizziness.

[30], [31], [32]