Sibazon

Sibazon is a tranquilizer with an anxiolytic effect. Its active ingredient is diazepam, which is in the benzodiazepine category.

The drug demonstrates hypnotic-sedative, anticonvulsant and central muscle relaxant activity. The effects of the medication are based on stimulating the endings of the benzodiazepine. Anxiolytic influence develops due to the action of the drug in relation to the amygdaloid complex, which is located inside the limbic system.

The drug reduces the intensity of feelings of anxiety, fear and anxiety, and besides emotional stress.

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Indications Sibazona

It is used for all types of anxiety disorders.

The drug is prescribed in case of insomnia, dysphoria (complex treatment), states of spastic nature (with cerebral and spinal lesions - tetanus, athetosis or cerebral palsy). In addition, it is used for arthritis, angina pectoris, spasms affecting the skeletal muscles, bursitis, pelvicopondiloarthritis of a rheumatic nature, chronic polyarthritis of a chronic nature in the progressive stage, myositis, HDN and vertebral syndrome.

It can also be used in the case of alcohol withdrawal: a feeling of tension or anxiety, agitation, tremor and transient reactive states.

As an integral part of the combined treatment, it is used for disorders of a psychosomatic nature in gynecology, ulcers affecting the digestive tract, gestosis, increased blood pressure, epistatus and eczema.

May be prescribed in the case of drug intoxication, Meniere's disease, and in addition as premedication before performing endoscopy or surgery under general anesthesia.

Sibazon is used to stop epileptic seizures, hallucinatory-paranoid states and motor excitations in neurology or psychiatry. Also introduced to facilitate the process of childbirth in case of premature detachment of the placenta.

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Release form

The release of the medicinal element is produced in tablets, as well as fluids for intramuscular and intravenous injections (inside ampoules).

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Pharmacodynamics

The influence on the nonspecific nuclei of the thalamus, as well as the reticular formation in the region of the cerebral trunk, provide a sedative effect, and in addition weaken the intensity of manifestations that are of a neurotic nature (anxiety and fear).

Suppression of cells of the reticular formation inside the cerebral trunk leads to the development of hypnotic activity. Potentiation of presynaptic slowing causes an anticonvulsant effect.

Sibazon inhibits the spread of epileptogenic activity, without affecting the excitation of its focus at the same time. Slowing down of the spinal braking ducts of the afferent polysynaptic nature leads to the development of a muscle relaxant effect having a central origin.

The drug can cause a decrease in blood pressure and have a vasodilating effect on the coronary vessels. The drug increases the border pain sensitivity, and in addition can inhibit parasympathetic, vestibular, as well as sympathoadrenal paroxysms. The drug reduces the production of gastric juice at night.

The development of a therapeutic effect is observed on the 2-7th day of treatment. In the case of chronic withdrawal symptoms or alcoholism, diazepam leads to a decrease in the intensity of tremor, hallucinations, negativity, agitation, and also alcoholic delirium.

In individuals with cardialgia, arrhythmias, or paresthesias, the drug effect is observed by the end of the 1st week.

Dosing and administration

The drug is taken orally, and in addition is administered intramuscularly or intravenously. It is assumed that the combined treatment with the use of tablets and solution.

The dosage portion is selected, taking into account the sensitivity to the drug, personal response and clinical picture.

In psychiatry: in the case of dysphoria, phobia, neurosis, the development of hysterical or hypochondriacal symptoms, the drug is used in a dose of 5-10 mg 2-3 times a day.

As an anxiolytic agent, diazepam is used in a dosage of 2.5-10 mg 2-4 times a day. In some situations, a portion of the drug is allowed to increase to 60 mg per day.

In case of alcohol withdrawal, the medicament on the first day is used at a dosage of 10 mg 3-4 times a day. Later, a portion of the drug is reduced.

Persons with impaired immunity or atherosclerosis, as well as the elderly, use diazepam at a dosage of 2 mg 2 times a day.

In neurology: in the case of spastic states or diseases of a degenerative nature with a central nature, Sibazon is used in a dose of 5-10 mg, with 2-3 times daily use.

In cardiology and rheumatology practice: in case of an increase in blood pressure or angina, 2-5 mg, 2-3 times per day; with the development of vertebral syndrome - 10 mg 4 times a day.

The drug is used in combination therapy in the case of myocardial infarction: first, 10 mg of the substance is administered in the intramuscular system, and later taken orally in 5-10 mg 1-3 times a day.

During defibrillation, as a means of sedation, the drug is used in / in the method, in separate portions - at low speed in a portion of 10-30 mg.

In the case of vertebral syndrome or spastic conditions having a rheumatic nature, 10 mg of the substance is first administered intramuscularly, and then ingested 5 mg 1-4 times a day.

In obstetrics and gynecology: in the case of menopausal or menstrual disorders, and in addition, for a disease having a psychosomatic nature, or preeclampsia, it is necessary to take 2-5 mg of the drug 2-3 times a day.

In the case of pre-eclampsia, 10-20 mg of the drug is first administered intravenously, and later, 5-10 mg of the substance is taken orally 3 times a day.

Continuous therapy is performed in case of premature discharge of the placenta - this is done until the fetus is fully ripe.

For sedation in anesthesiology and surgery: before surgery, you need to take 10-20 mg of Sibazon.

In pediatrics: during psychosomatic and reactive disorders or spastic states, the size of the dosage should be increased gradually.

In the case of epistatus or relapses of epilepsy, the medication should be administered parenterally: children younger than 5 years old - intravenously at a low speed (0.2-0.5 mg each at 2-5 minute intervals). The maximum dose size is 5 mg.

In the case of injuries affecting the spinal cord, against which paraplegia or hemiplegia occurs, and besides with chorea, the drug is used intramuscularly in a portion of 10-20 mg.

For persons with motor excitation, the drug is administered intravenously or intramuscularly in a dose of 10–20 mg, 3 times a day.

To eliminate pronounced muscle spasms, the drug is administered intravenously in a 10 mg dose, 1-fold.

Use Sibazona during pregnancy

In pregnancy, diazepam is prescribed only if there are strict indications.

The use of drugs in the first trimester increases the risk of congenital anomalies, and at the same time leads to the development of a pronounced toxic effect on the fetus.

The use of Sibazon in the late stages of pregnancy causes suppression of the central nervous system in newborns. In the case of regular use of the drug during pregnancy, there is a development of physical dependence, and in addition, the appearance of a withdrawal syndrome in the newborn child is sometimes noted.

Contraindications

The main contraindications:

• the presence of strong sensitivity towards diazepam;
• acute poisoning with other drugs;
• acute alcohol poisoning, which affects the vital organs;
• glaucoma, having a closed-angle character;
• myasthenia;
• severe COPD;
• acute respiratory failure;
• absenza;
• lactation period.

Caution is required when prescribing in such cases:

• the presence of epilepsy and its seizures in history;
• cerebral or spinal ataxia;
• elderly age;
• lack of kidney or liver function;
• cerebrospinal pathology of organic character;
• sleep apnea;
• addiction to abuse of psychoactive substances;
• medical history of drug dependence.

Side effects Sibazona

The use of drugs, especially in the initial phase of therapy, can cause side effects:

• NA lesions: deterioration in concentration, dizziness, disorientation, ataxia, and severe fatigue. In addition, poor motor coordination, emotional dullness, instability of gait, euphoria, drowsiness and tremor, affecting the limbs. Also, inhibition of mental and motor reactions, catalepsy, anterograde amnesia, confusion, headaches, worsening of mood or depression, as well as dysarthria, weakness, irritability, hallucinations with hyporeflexia, myasthenia over the course of a day, increased excitement and paradoxical reactions are also noted. At the same time, it is possible to develop suicidal tendencies, aggressive outbursts, psychomotor agitation, muscle spasm, insomnia, feelings of fear or anxiety, as well as uncontrolled bodily movements;
• disorders associated with digestion: vomiting, yellowness, loss of appetite, hypersalivation, and in addition dryness of the oral mucous membranes, nausea, positioning and an increase in the values of hepatic enzymes;
• disorders of the blood-forming organs: platelet, leuko- or neutropenia, agranulocytosis or anemia;
• problems with the CVS function: after parenteral administration, a heartbeat, a decrease in blood pressure and tachycardia are observed;
• lesions of the urogenital tract: delayed urination, dysmenorrhea, renal dysfunction or libido;
• allergy symptoms: rash or itching. Also, swelling, phlebitis, redness or thrombosis may appear in the area of drug administration;
• other manifestations: visual perception disorders (diplopia), weight loss, bulimia, suppression of the respiratory center and problems with the work of external respiration.

In the case of abrupt discontinuation of the use of drugs or a reduction in the portion, a “withdrawal” syndrome occurs, in which irritability, depersonalization, anxiety, hyperhidrosis, depression and dysphoria develop. In addition, there is also nervousness, acute psychosis, sleep disturbance, convulsions and a spasm of smooth muscle tissues, and with it hallucinations, headaches, photophobia, tremor, hyperacusis, impaired perception and paresthesia.

Overdose

Using too large portions of Sibazon leads to a weakening of reflexes, confusion, paradoxical arousal, deep sleep and drowsiness, and in addition to bradycardia, weakening of the response to pain, tremor and areflexia, stunnedness, nystagmus, impaired visual perception, collapse, suppression of respiratory and CVS functions, as well as to coma.

It is required to use enterosorbents, perform gastric lavage and mechanical ventilation (if necessary), and in addition to maintain normal respiratory parameters and blood pressure values.

Antagonist of drugs is the substance flumazenil, used only in the hospital. This component is a benzodiazepine antagonist; therefore, it cannot be used in people with epilepsy who use benzodiazepines, because this can trigger epilepsy episodes.

Hemodialysis procedures will be ineffective.

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Interactions with other drugs

Sibazon potentiates the intensity of the overwhelming influence on the central nervous system, which has antipsychotics, muscle relaxants, antipsychotics, antidepressants, and in addition sedatives, opioid analgesics and drugs for general anesthesia.

Potentiation of the effect and prolongation of the term half-life is observed when a combination of drugs with propranolol, fluoxetine, valproic acid, disulfiram, propoxyphene, and in addition with ketoconazole, erythromycin, metoprolol, oral contraception, isoniazid, ciptidine, and other pops of a real world, is also associated with the same pops of the object, and other pops of the pops and other subjects who are also populated by other objects and other pops.

The therapeutic effect of the drug is weakened when using inducers of microsomal liver enzymes. Strengthening of psychological dependence and euphoria is observed in the case of combination of the drug with opioid analgesics.

Antacids do not affect the degree of absorption of diazepam, but at the same time reduce its speed.

The use of antihypertensive drugs leads to a potentiation of the severity of a decrease in blood pressure indicators.

The combination with clozapine causes potentiation of the suppression of respiratory activity.

Competition for protein synthesis increases the likelihood of digitalis poisoning when using low-polarity SG.

In people with parkinsonism, the use of diazepam reduces the effects of levodopa.

The term drug excretion is prolonged with the introduction of omeprazole.

The effect of the drug is weakened in the case of the use of MAOI, analeptics or psychostimulants.

Sibazone may potentiate the toxic properties of zidovudine.

The sedative effect of the drug is weakened and changes when combined with theophylline.

Rifampicin reduces the performance of the active element of the drug, potentiating its excretion.

The drug is not compatible with other drugs, because of what it is not mixed with them inside a single syringe.

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Storage conditions

Sibazon must be kept in a closed place from small children and sunlight. Temperature level - maximum 30 ° C.

Shelf life

Sibazon is allowed to apply within 5 years from the date of production of the drug.

Application for children

When using the drug in infants, as well as premature babies, hypothermia, shortness of breath and muscle hypotension are observed.

Small children are most susceptible to the overwhelming influence of benzodiazepines in relation to the function of the central nervous system. It is forbidden to use in children drugs containing benzyl alcohol, because it can provoke toxic syndrome with the probability of death. It manifests itself in the form of suppression of the central nervous system, breathing problems, a decrease in blood pressure, metabolic acidosis, and besides epilepsy attacks, hemorrhages inside the skull and renal function failure.

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Analogs

Analogues of drugs are means Relanium, Diazepam and Relium.

Reviews

Sibazon is inexpensive and at the same time quite effective tranquilizer. In the case of proper use with compliance with the recommendations of addiction does not lead. It has an effective soothing effect and helps well in case of severe problems associated with excitability.

Of the negative reviews, there are a large number of side effects and contraindications, and besides the fact that the medicine is not too safe, and you need a medical prescription to buy it.

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