Terapin

Therapeutin is a drug from the category of NSAIDs and has a pronounced analgesic, anti-inflammatory and antipyretic effect.

Indications Terapina

It is used to treat such diseases:

• rheumatism (without reference to the form or stage of pathology);
• rheumatoid arthritis;
• having infectious-allergic genesis myocarditis;
• inflammation in the area of the serous cardiac membrane (pericarditis);
• Chorea Sydenham;
• fever condition;
• pain syndrome (this includes pain in diseases of the gums and teeth, migraine, and also after performing dental procedures);
• neuralgia (including maxillofacial type);
• having a diverse etiology of myalgia;
• thrombophlebitis;
• arthralgia or lumbago;
• Kavasaki syndrome ;
• atrial fibrillation;
• heart valve disease;
• prolapse 2-leaf valve;
• postinfarction syndrome.

Together with this, it is used as an antiplatelet drug (an analogue of aspirin) and is prescribed for the treatment or prevention of angina, myocardial infarction, brain ischemia or myocardium (without pain), and in addition during rehabilitation after performing coronary angioplasty, as well as prosthetic heart valves.

After surgical procedures, the drug reduces the likelihood of unexpected bleeding and other complications.

[1], [2]

Release form

The release of the drug is sold in tablets, in the amount of 100 pieces inside the bottle.

[3], [4]

Pharmacodynamics

The therapeutic result is achieved by selectively slowing down the activity of the COX-1 and COX-2 elements, which regulate the binding of Pg. The antipyretic effect develops with a decrease in Pg, as a result of which the epidermal vessels widen and sweating increases.

Aspirin has a powerful analgesic effect. It provides a prolonged anti-aggregation effect by inhibiting the binding of thromboxane type A2 within the platelets. Anti-aggregation activity persists for a period of 7 days after drug use.

Therapin prolongs the PTV rate and reduces the blood coagulability, resulting in a reduced likelihood of breakthrough bleeding in the treatment with anticoagulants and during surgical procedures.

[5], [6], [7], [8]

Pharmacokinetics

Aspirin per serving of 1-10 mg / kg per day is absorbed inside the gastrointestinal tract at a good level and high speed. Combined use with food slows down the process. During absorption, presystemic elimination of the drug inside the intestinal wall and liver is observed, where deacetylation is performed. Plasma Cmax values are noted after 10-20 minutes. The rate of synthesis with protein is determined by the level of drug concentration and is approximately 49-70%.

The metabolic processes of the Therapin proceed inside the liver, where salicylic acid is formed together with its glycine conjugate, and in addition, 2,5-dihydroxybenzoic acid (also with its glycine conjugate).

Metabolic products of aspirin are mainly excreted through the kidneys. Half-life is approximately 20 minutes. The rate of excretion is determined by the size of the portion. In case of its increase, half-life can reach up to 15-30 hours, especially for people with problems in the work of the kidneys.

[9], [10]

Dosing and administration

The drug is prescribed for oral administration. The size of the portions and the duration of therapy are chosen by the physician individually.

The size of the daily dosage for an adult - 0.5-1 g of the drug (with urgent need may increase to 3 g). The drug is used 1-fold or divided into 3 doses per day.

Teenagers (over 12 years old) should consume a maximum of 0.25 g of medication per day. Apply it 2 times a day (in the morning, and then before bedtime).

Children of the age range of 7-11 years old - 0.3 g per day. Children aged 4-6 years - 0.2 g per day. A child of 2-3 years old - 0.1 g per day.

Approximate mode of use in a variety of pathologies.

In the case of myocardial infarction, the medicament is taken 1-fold per 325 mg dose.

With circulatory disorders that are dynamic in nature (mostly in men), the size of the initial dosage per day is 325 mg, and then increases to 1 st.

To prevent the development of acute thrombosis or occlusion of the aortic shunt, it is necessary to inject the substance intranasally - in portions of 325 mg at 7-hour intervals, and then take it inside, 3 times a day, at a dosage of 325 mg.

[16], [17]

Use Terapina during pregnancy

Do not use the drug during pregnancy.

Contraindications

Main contraindications:

• "Aspirin triad";
• allergy symptoms associated with the action of the elements of the drug;
• gastric ulcer or gastritis erosive-ulcerative nature;
• thrombocytopenia;
• bleeding inside the digestive tract;
• hemorrhagic diathesis;
• aortic aneurysm;
• breastfeeding period;
• vitamin K deficiency;
• portal hypertension;
• disorders of the liver or kidneys in severe.

Caution is required when used in such conditions:

• urolithiasis urate character;
• having decompensated form of CHF;
• gastric ulcer of decompensated nature;
• kidney or liver disease;
• duodenitis, gout or gastritis.

[11]

Side effects Terapina

The use of a pharmaceutical agent may provoke the following side effects:

• dyspeptic disorders (loss of appetite, abdominal pain, bloating, diarrhea, vomiting, constipation and nausea);
• allergy symptoms (urticaria, angioedema, dermatological itching, and exacerbation of eczema or dermatitis);
• aspirin asthma;
• kidney problems;
• an increase in blood platelet values (may reach acute thrombocytopenia);
• anemia;
• an increase in blood indicators of leukocytes (sometimes a severe severity of leukopenia develops);
• white liver disease;
• dysfunction of the central nervous system (feeling of severe fatigue or anxiety, dizziness, sleep disorders, headaches and apathy);
• hypercalcemia;
• runny nose;
• gastritis in the acute phase;
• transient visual disturbances;
• transient deterioration of hearing acuity;
• nephrotic syndrome;
• ear ring;
• spasm of the bronchi in acute form;
• fluid retention within the body.

[12], [13], [14], [15],

Overdose

During therapy, it is necessary to carefully follow the recommended treatment regimen. The use of large dosages can cause dizziness, ear noise, nausea, paralysis, headaches, feelings of anxiety, and in addition to vomiting, fever, pulmonary hyperventilation, as well as loss of consciousness.

If signs of poisoning develop, you should immediately contact a doctor to get urgent help.

Symptomatic procedures are performed - gastric lavage, the use of activated carbon, the monitoring of KOS and electrolyte balance, and so on.

[18], [19], [20], [21]

Interactions with other drugs

Aspirin potentiates the toxic properties of methotrexate, and also lowers the values of its renal clearance, which increases the likelihood of the development of insufficiency in the kidneys or exacerbation of the course of nephritis.

The drug weakens the effects of opiates, thrombolytics, indirect anticoagulants, reserpine, platelet aggregation inhibitors, antidiabetic and antihypertensive drugs, as well as uricosuric drugs.

The combination with ethyl alcohol increases the likelihood of damage to the walls of the gastric mucous membranes and the risk of bleeding inside the gastrointestinal tract.

Aspirin increases the lithium salts, digoxin and barbiturates inside the blood plasma, which can cause poisoning.

The combination of magnesium and antacids slows down the absorption of aspirin.

The hematotoxic properties of Therapin are enhanced when used with myelotoxic drugs.

[22], [23], [24]

Storage conditions

Therapin is required to be kept in a dark and dry place, closed to children. The temperature level is within the limits of 15-25 ° С.

[25], [26]

Shelf life

Therapin can be used within 36 months from the date of release of the drug.

[27], [28]

Application for children

It is forbidden to assign Terapin babies. Caution is required when used in children younger than 15 years of age.

[29]

Analogs

Analogues of the medication are drugs Aspiquor, Aspirin Cardio with acetylsalicylic acid and Aspirin Express.

[30], [31], [32]

Reviews

Therapin receives a large number of reviews, and the opinion of him in patients is rather contradictory.

There are a considerable number of people who noted its effectiveness - the drug helped to improve the condition in various severe illnesses, reduced the likelihood of bleeding and prevented the development of certain complications in the CVS area.

Of the minuses, patients emit a fairly large number of negative manifestations and contraindications, and in addition, it is rather difficult to find in pharmacies.