Recote

Rekut is an antimicrobial drug that contains clavulanic acid and amoxicillin.

[1]

Indications Recote

It is used as an antimicrobial agent with a large range of influence - for therapy in such cases:

• infections of a mixed nature, triggered by the activity of anaerobes and gram-negative and positive bacteria;
• lesions affecting the ENT organs (otitis media, tonsillitis, among which are also recurrent, and sinusitis);
• lesions of the respiratory ducts (pneumonia or bronchitis);
• disorders affecting the connective and bone tissues (this includes chronic osteomyelitis);
• problems in the area of soft tissues and epidermis (wound lesions and phlegmon are among them);
• lesions of the urethra (among those urethritis with cystitis and pyelonephritis).

[2], [3]

Release form

The release of the drug is sold in tablets with a volume of 500/125, as well as 875/125 mg.

Pharmacodynamics

Amoxicillin is a penicillin antibiotic and has a large range of therapeutic activity. Clavulanic acid is a substance that slows down the activity of β-lactamase; she creates with these elements stable complex ligaments that do not possess activity, and also protects amoxicillin from decay.

The drug has a wide range of antimicrobial effects. It has activity against amoxicillin-sensitive bacteria and resistant microbes that synthesize β-lactamase. It affects gram-positive (staphylococci with streptococci, enterococci, etc.) and negative bacteria (Shigella with Klebsiella, as well as Salmonella and others).

Pharmacokinetics

Suction.

Clavulanate and amoxicillin fully dissociate inside an aqueous solution at physiological pH. After ingestion, both of these elements are well absorbed at high speed. To optimize the process of their absorption is possible by applying the medicine at the beginning of the use of food. The level of bioavailability of the components reaches the level of about 70%. Their profile inside the plasma is quite similar, and the period required to obtain peak indicators (Tmax), they both are about 60 minutes.

Distribution processes.

Approximately 25% of clavulanate, as well as 18% of amoxicillin (of the total plasma index) is synthesized with protein. The distribution volume varies between 0.3-0.4 l / kg (amoxicillin) and approximately 0.2 l / kg (clavulanate).

Animal tests did not record the accumulation of these elements inside any organs.

Like many penicillins, amoxicillin is able to pass inside the mother's milk. It may also contain trace amounts of clavulanate. In addition, there is evidence that these components pass through the placenta.

Exchange processes.

Part of amoxicillin is excreted in the urine in the form of inactive penicillic acid (approximately 10-25% of the initial batch). Clavulanate undergoes extensive metabolism, after which it is excreted with feces and urine, and in addition, in the form of carbon dioxide with exhaled air.

Excretion.

The main route of excretion of amoxicillin is the kidney, while clavulanate can be excreted by the kidneys, and in other ways.

In healthy people, both components have approximately the same half-life - about 1 hour, and the average total clearance - about 25 l / minute. About 60-70% of amoxicillin, as well as about 40-65% of clavulanate is excreted unchanged in the urine (for the first 6 hours after 1 single dose of tablets 500/125 mg).

In combination with probenecid, the excretion of amoxicillin is delayed, while the removal of clavulanate through the kidneys is unchanged.

Elderly age.

Older people are likely to reduce renal activity, which is why it is necessary to carefully select the dosage, and at the same time monitor the work of the kidneys during therapy.

Persons with kidney problems.

General indicators of intra-serum clearance in amoxicillin with clavulanate decrease in proportion to the weakening of the renal function.

A decrease in drug clearance is more strongly reflected in amoxicillin, because it is more excreted through the kidneys. In this regard, when assigning servings to people with kidney problems, care must be taken to ensure that excessive accumulation of amoxicillin does not develop, while at the same time maintaining the required levels of clavulanate.

People with impaired hepatic activity.

People with this disorder need to carefully select the dosage of drugs and constantly monitor the work of the liver.

[4], [5]

Dosing and administration

Rekut is used in portions, the size of which is determined by the severity of the disease, the age and weight of the patient, as well as his condition. The selection of dosage deals with the attending doctor.

Adolescents from 12 years old and adults are often prescribed 1-well pill with a volume of 500/125 mg 2 times a day. If there is a severe stage of an infectious lesion, take a pill of 875/125 mg 2 times a day.

[8]

Use Recote during pregnancy

The drug can be given to pregnant women, provided they have vital indications, only in cases where the likely benefits of its use are more expected than the risk of any complications in the mother or fetus.

Rekut penetrates into the mother's milk, because of what you need to abandon breastfeeding at the time of therapy.

Contraindications

Among the contraindications:

• the presence of strong sensitivity to clavulanate, amoxicillin, antibiotics from penicillins in the history or other elements of drugs;
• hepatitis or cholestatic jaundice, caused in the past by the use of penicillin antibiotics.

[6]

Side effects Recote

Often the medication causes the appearance of such side effects:

• dysfunction of the digestive tract: vomiting, diarrhea or nausea;
• allergy symptoms: urticaria, erythema multiforme, rash, allergic vasculitis nature and anaphylaxis;
• thrombocyto-, neutro- or leukopenia, and in addition, hemolytic forms of anemia and agranulocytosis;
• headache or dizziness.

Occasionally, hyperactivity, hematuria, seizures, tubulointerstitial nephritis, and colitis associated with antibiotics occur.

Weakening of negative symptoms is noted when using pills at the beginning of the meal.

[7]

Overdose

Poisoning can lead to dysfunction of the gastrointestinal tract (vomiting, diarrhea or nausea), and in addition to the excitation of the activity of the central nervous system (convulsions, agitation, as well as insomnia).

To eliminate the disorders, symptomatic procedures and hemodialysis sessions are prescribed.

[9]

Interactions with other drugs

Anticoagulants for ingestion.

There is evidence of an increase in the INR values in people who have received supportive treatment with warfarin or acenocumarol together with amoxicillin. With the need for a combined administration, it is necessary to carefully monitor the values of the PTV or INR (in case of additional use or withdrawal of amoxicillin). In this case, it may also be necessary to change the portion of anticoagulants.

Methotrexate.

Penicillin antibiotics are able to reduce the excretion of methotrexate, because of which its toxic properties may increase.

Probenecid.

Combining Recoute with probenecid is prohibited, because the latter weakens the release of amoxicillin through the renal tubules. Also, the use of probenecid may cause an increase in performance and prolongation of the period of amoxicillin inside the blood (no effect on clavulanate).

Allopurinol.

Combination with allopurinol may lead to an increase in the likelihood of signs of allergy to the epidermis.

Like other antibiotics, the drug can affect the intestinal microflora, which reduces the reabsorption of estrogens, as well as the effectiveness of combined oral contraception.

[10], [11]

Storage conditions

Recipe is required to contain at temperature values of not more than 25 ° C.

Shelf life

Rekut can be used within 24 months from the date of release of the medication.

Application for children

You can not assign tablets Rekuta in Pediatrics (children under 12 years of age).