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Capture
Last reviewed: 23.04.2024
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Captopress is a combination antihypertensive medication.
Indications Captopres
It is used for various types of hypertension with arterial character.
Release form
The release of the drug substance is realized in tablet form (10 pieces inside the blister pack). In the box - 1 or 2 similar packages.
Pharmacodynamics
The drug contains 2 active elements - hydrochlorothiazide with captopril. It has powerful diuretic and antihypertensive properties. Its drug activity and principle of action are based on the properties of its constituents.
Substance captopril is included in the category of ACE inhibitors. The component helps to reduce blood pressure values, weakens the systemic resistance exerted by peripheral vessels, and the preload relative to the myocardium, and at the same time increases the cardiac volume and stability regarding physical activities. It acts by slowing down the activity of the ACE element, as a result of which the process of transformation of angiotensin-1 into angiotensin-2 is suppressed, which has a strong vasoconstrictor effect.
Hydrochlorothiazide is a diuretic substance of thiazide nature. It potentiates the excretion of potassium, sodium and chloride ions, as well as liquids. Enhances the hypotensive activity of captopril.
Pharmacokinetics
After ingestion, the active elements of the drug are well absorbed inside the gastrointestinal tract. Plasma Cmax values of captopril are recorded after the expiration of the 1st hour from the moment of oral administration, and hydrochlorothiazide - after 1-2.5 hours. Approximately 30% of captopril undergoes intraplasma protein synthesis.
Excretion of active substances to a greater extent flows with urine (unchanged elements and metabolic products). The half-life of captopril is 45–120 minutes, and that of hydrochlorothiazide, is 5.5–15 hours.
Hydrochlorothiazide is able to overcome the hemato-placental barrier and may be excreted in mother's milk.
Dosing and administration
The medicine is taken orally, swallowing the pill whole, (no need to grind or chew). It is necessary to wash down the drug with plain water. If necessary, it is allowed to divide the tablet in half. Drug use is not tied to food intake. The duration of the therapeutic cycle is selected by the attending doctor, individually for each patient.
Adults with healthy renal activity should first use 25 mg of the drug 2 times a day. Later, when needed, the portion is increased to 50 mg of the substance 2 times a day.
Per day, a maximum of 0.1 g of captopril and 50 mg of hydrochlorothiazide is allowed.
People with disorders in the kidneys and indicators of KK in the range of 30-80 ml / minute are required to first apply the medication in a dose of 25 mg 1 time per day. Perform the reception of drugs is recommended in the morning.
During therapy, it is required to monitor the plasma values of urea and potassium with creatinine, and in addition, the function of peripheral blood.
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Use Captopres during pregnancy
You can not assign Kaptopres to breastfeeding mothers or pregnant women.
Contraindications
It is not prescribed for the reception of people with a strong personal intolerance regarding the elements of the drug, preparations from the category of ACE inhibitors, and besides this derivatives of sulfamide.
It can not be used in patients with disorders of the kidneys in the severe stage (KK indicators - below 30 ml / minute or plasma creatinine level above 1.8 mg / 0.1 l), stenosis in the renal artery (or both kidneys), and together with this in patients who have had a kidney transplant.
It is contraindicated to be prescribed to people with obstructive disorders when there is a violation of blood outflow from the left ventricular area (also aortic stenosis), and in addition with Conn's syndrome, reduced plasma values of sodium with potassium, and with it gout, as well as hypovolemia or hypercalcemia.
Also Kaptopres not used for liver pathologies with severe severity.
The drug is used cautiously in individuals with immune disorders, CC indicators within 30-60 ml / minute and an increased level of protein inside the urine (more than 1 g per day), and in addition, for those who use procainamide.
It is also necessary with caution to prescribe medication to people with HF, disorders affecting renal activity, increased blood pressure inside the kidneys, elderly people and diabetics. In the case of the use of drugs in these groups of patients, it is necessary to constantly monitor the values of blood pressure, blood electrolyte values and renal activity.
People who use diuretic substances should stop using them at least 3 days before they start taking Captopress.
Caution is required when administering drugs to people who drive a car or operate machinery that could be life-threatening.
Side effects Captopres
The introduction of the drug may cause the appearance of some adverse symptoms:
- liver and gastrointestinal lesions: vomiting, upset stool, loss of appetite, epigastric pain, nausea, dry oral mucous membranes and stomatitis. In addition, jaundice, peptic ulcer, hyperbilirubinemia and hepatitis;
- disorders of the hematopoietic processes and the work of the cardiovascular system: angina pectoris, Raynaud's disease, decrease in blood pressure, tachycardia, pallor of the epidermis or hyperemia, thrombocyto, neutro or pancytopenia, and in addition, cardiogenic shock, anemia of aplastic or hemolytic nature and agranulocytosis;
- disorders of the PNS and CNS function: headaches, feeling of confusion, disorder of the daily regimen, dizziness, ear noise, emotional instability, stroke, paresthesias, and disruption of the taste and visual receptors;
- problems with the work of the respiratory system: bronchial spasms, cough, respiratory distress and runny nose allergic nature;
- urinary disorders: polyuria or nephrotic syndrome, severe renal impairment and oliguria;
- signs of allergy: urticaria, erythema, angioedema, rash, photosensitivity, itching and Stevens-Johnson syndrome;
- changes in test results: an increase in urea nitrogen with bilirubin, and in addition, creatinine with calcium inside the blood plasma, a decrease in blood glucose and sodium, decreased hematocrit with platelets, and also leukocytes with hemoglobin, as well as the development of proteinuria;
- Other: pain in the chest region, and in addition to the joints or muscles, muscle spasms, fever, alopecia, gynecomastia or impotence.
Overdose
Using too large portions of Captopres leads to tachycardia, nausea, headaches, stool disorders, neutropenia, vomiting and anorexia, and in addition to a decrease in blood pressure values. The subsequent increase in dosage causes the appearance of signs of hydrochlorothiazide intoxication, a disorder of EBV balance and a state of coma (as a result of the effects of the drug on the central nervous system).
To eliminate violations, you must first perform a gastric lavage, and then give the patient enterosorbents. Symptomatic measures are taken when required.
In case of severe intoxication with hydrochlorothiazide, it is necessary to hospitalize the victim in order to carry out hemodialysis and the procedures required to restore and maintain EBV and SSS performance. In addition, it may be necessary to perform procedures that support the activity of the respiratory system, kidneys and central nervous system.
Interactions with other drugs
The combination with MAOIs, vasodilators, diazoxide, ganglioblokatorami, diuretic drugs and adrenergic blockers causes an increase in the antihypertensive activity of the drug.
Diuretic, with potassium-sparing ability, and potassium drugs when used together with Captopress increase the values of potassium inside the plasma and increase the likelihood of hyperkalemia.
There is a decrease in the effectiveness of the drug in the case of its combination with methenamine or NSAIDs.
The combination of a substance with lithium means leads to an increase in the plasma values of the latter.
Simultaneous use with barbiturates, ethanol and narcotic drugs increases the likelihood of orthostatic collapse.
The combination with corticosteroids, amphotericin B, and in addition with adrenocorticotropic hormone can lead to the appearance of electrolyte metabolism disorders.
Captopress can potentiate plasma calcium levels.
The drug potentiates the toxic activity of SG when combined with them.
Use with medication may require correction of a portion of hypoglycemic substances, anti-gouty drugs, sulfinpyrazone, probenecid, as well as oral anti-coagulants.
Colestipol with colestiramine weaken the absorption of hydrochlorothiazide.
It is also necessary to stop the use of the drug at least 7 days before the planned operation.
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Shelf life
Captopress can be used within a 3-year period from the date of manufacture of the therapeutic substance.
Application for children
Not used in pediatrics (children under the age of 18).
Analogs
The following drugs are considered to be analogues of drugs: Caposid, Liprazid, Ramipril and Normopres with Enalozide, and in addition Noliprel, Accuzid, Hartil-N, Enzix with Co-Dyroton, Berlipril plus Enzix duo and Ramiz com.
Attention!
To simplify the perception of information, this instruction for use of the drug "Capture" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.