Zoloft

Zoloft has an antihypertensive effect.

Indications Zolota

It is used in the following disorders:

• depression states of various forms;
• OCD;
• panic disorders;
• socio-phobia;
• PTSR.

[1], [2], [3], [4]

Release form

The release is made in tablet form, in the amount of 14 pieces (with a volume of 50 or 100 mg) inside a cellular packaging. Inside the pack - 1-2 packs.

Pharmacodynamics

Sertralin is an extremely powerful antidepressant, which is a strong specific IOPS within neurons. In addition, it has a weak effect on the processes of reverse norepinephrine and dopamine capture. Drug portions of the substance helps to seize serotonin in platelets.

The drug does not have sedative, anticholinergic or stimulating properties, and at the same time does not increase the adrenergic effect. Also, the component does not lead to the development of drug dependence, weight gain and other negative symptoms.

[5], [6], [7],

Pharmacokinetics

The medication has a good, but rather slow absorption. Increased bioavailability values occur when used with food. Food increases Cmax, but at the same time shortens the period of medical exposure.

Approximately 98% of the active element undergoes protein synthesis. Transformed inside the liver, sertraline forms the main metabolic product - a component of N-desmethyl-sertraline, which has a lower activity.

Excretion of the substance is carried out with urine and feces.

[8], [9]

Dosing and administration

Zoloft is required to be consumed in the amount of the 1st tablet in the morning, as well as in the evening, every day.

The size of the initial portion is determined by the type of disorder - in case of depression, 50 mg should be applied per day. In case of social phobia and panic disorders, you should first use 25 mg of drugs per day. This approach avoids the appearance of early negative symptoms characteristic of panic disorders.

Further, the dosing portion may be increased, but this can be done a maximum of 1 time per week. The size of the maximum daily dosage in this case is 0.2 g.

The development of drug influence is noted after 7 days, but the full effect should be expected after 2-4 weeks.

In the case of prolonged therapy, it is required to apply a minimally acting supporting portion, which is sometimes changed, taking into account the severity of the therapeutic effect.

[12], [13], [14]

Use Zolota during pregnancy

It is forbidden to appoint lactating or pregnant women.

Contraindications

Among the contraindications:

• the presence of intolerance against sertraline;
• combined use with pimozide or IMAO.

Gently, the drug is used if the patient has epilepsy, which has an organic nature of cerebral diseases, insufficiency of the kidneys or liver, as well as pronounced weight loss.

[10]

Side effects Zolota

The use of a drug substance can provoke the occurrence of adverse events that are associated with digestive activity - in the form of dyspeptic disorders (vomiting, constipation, pain in the abdominal area, bloating, pancreatitis, diarrhea, nausea, etc.).

In addition, there may be disorders of the function of the NA, cardiovascular system, urinary, respiratory, motor and other systems.

Also sometimes there are problems with the visual organs and develop a variety of allergy signs and systemic manifestations.

At times, when discontinuing the use of sertraline, a withdrawal syndrome occurs, in which hypesthesia, hallucinations, aggressive symptoms, paresthesias, depressive symptoms, psychosis or anxiety, and also psychomotor agitation, are noted, which makes it difficult to determine the diagnosis accurately.

[11]

Overdose

The use of large portions of Zoloft did not cause the appearance of severe symptoms. But with the introduction of drugs, along with other medicines, symptoms such as vomiting, diarrhea, agitation of a psychomotor nature, tachycardia, nausea, and also dizziness, agitation, hyperhidrosis, drowsiness, hyperreflexia and myoclonus may appear.

In case of such violations, it is necessary to perform symptomatic procedures, carefully monitoring the work of important systems of the body (especially respiratory).

[15]

Interactions with other drugs

The combination of medication and pimozide can significantly increase its performance inside the body, and, because pimozide has a rather narrow drug index, these drugs should not be used together.

The combination with MAOI causes the appearance of serotonin intoxication with rigidity, hyperthermia, and also with the instability of the autonomic NA, myoclonus, and so on. Such manifestations can lead to serious complications and threaten human life and health.

Use together with cimetidine significantly reduces the values of sertraline clearance.

Antiarrhythmic drugs (flekainid and propafenone) or tricyclics can cause a mutual increase in the indices of these components inside the body.

The use of products containing lithium may increase the incidence of tremors and other disorders of the function of the National Assembly, which is why such a combination should be used with extreme caution.

You can not combine sertraline with fenfluramine, tryptophan, as well as antipyrine, because this can cause disruptions in hepatic activity and dysfunction of the NA.

Prolonged administration of phenytoin with sertraline in portions up to 0.2 g often does not lead to the appearance of clinically significant negative signs. But you need to carefully monitor the dosage and plasma indicators of phenytoin after each change in the portion of these drugs.

The introduction of Zolofta together with sumatriptan can cause a feeling of weakness, a disorder of consciousness, an increase in tendon reflexes, a feeling of arousal or anxiety. Because of this, it is necessary to constantly monitor the state of health of individuals who are clinically justified in combination therapy with these agents.

[16]

Storage conditions

Zoloft must be kept in a dry place, protected from children.

Shelf life

Zoloft can be used within a 5-year period from the moment the medicinal substance is manufactured.

Application for children

Not used in children under 6 years of age.

The drug is often prescribed to children of 6-17 years old, who have observed the development of OCD.

Teens 13-17 years of age should take at the beginning of therapy 50 mg of the substance per day. Children 6-12 years of age during the first 7 days use 25 mg of the drug daily, after which the dosage is increased to 50 mg. Further, taking into account the drug efficacy and personal characteristics of the patient, the portion adjustment is performed (increase or decrease). To prevent overdose, with an increase in servings of 50 mg, it must be remembered that the weight in children is less than in adults.

[17]

Analogs

Analogues of the medication are the means Solotik, Advuin, Serenata, Seralin with Aleval, and in addition, Depreufolt, Accentra, Stimuloton, Sertralux, and Sertralina hydrochloride with Sertraloft and Torin with Depralin. In addition, the list of Zaloks, Sertralin, Serlift, A-depresin and so on.

[18],

Reviews

Zoloft is commonly used to treat a variety of phobias, depression and others NS disorders - about this and reported in a review, on health forums.

Often, patients have a high drug efficacy, but it is clarified that improvements are progressing rather slowly. However, it is reported that the use of drugs leads to the stabilization of the psychological state and sleep.

But it must be remembered that when treating with this medication, negative symptoms may appear - insomnia or, conversely, a strong feeling of drowsiness. In addition, there are comments that speak about the occurrence of diseases associated with hepatic and renal function.

Doctors believe Zoloft one of the most effective drugs to help improve the work of the National Assembly. But during the therapy, it is necessary to closely monitor the sizes of the portions, correct them in time and remember that there is a likelihood of negative drug interaction with other drugs. Because of this, it is only the doctor who can prescribe therapy and control it.