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Zolsana
Last reviewed: 23.04.2024
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Zolsana is a substance similar to benzodiazepine. Contains zolpidem component.
Release form
The release of the therapeutic element is in tablet form, 10 pieces inside the cell plate. Inside the pack contains 3, 6, 9 or 12 such records.
Pharmacodynamics
Zolpidem is a hypnotic drug similar to benzodiazepines. Included in the category of drugs imidazopyridines, provoking the development of sedative and hypnotic influence (by providing a specific agonistic effect on the central benzodiazepine endings that are part of the macromolecular complex endings GABA-ω (BZ1 and BZ2), which is located in neural membranes and acts by opening the chlorine ion channels ).
The high selectivity of zolpidem relative to the first subtype of ω1-terminations (BZ1) contributes to the development of a significant sedative effect at dosages that are lower than those causing muscle relaxant, anticonvulsant and anxiolytic activity.
Pharmacokinetics
Zolpidem is fully absorbed and absorbed at high speed, which leads to the rapid development of hypnotic influence.
After oral administration, the level of bioavailability is 70%. In the case of the systemic exchange processes, the absolute bioavailability index is about 35%. Plasma Cmax values are recorded after 0.5-2 hours after using the drug. Therapeutic plasma parameters are determined in the range of 80-200 ng / ml. The level of distribution volume - 0.54 l / kg; in older people, this figure decreases to the level of 0.34 l / kg. Intrasoplasma synthesis with protein - approximately 92% of the active element.
Intrahepatic metabolic processes lead to the formation of several metabolic products that do not have medication activity. A small part of zolpidem penetrates into mother's milk.
The average half-life is 2.4 hours, with a duration of influence of 6 hours. Excretion in the form of inactive metabolic products is carried out with urine (by 56%) and feces (by 37%).
Dosing and administration
The therapeutic cycle should be as short as possible - no longer than 14 days. The maximum allowable duration of therapy is 1 month, which also includes the segment during which the drug is gradually phased out. In exceptional situations, prolongation of the therapy period is allowed.
The duration of the treatment cycle is determined by the doctor, taking into account the course of the disease and the condition of the patient. It is necessary to take medication orally, in the evening, before bedtime. For the day should be applied to 10 mg of the substance. At the same time, elderly people, patients with sensitivity to zolpidem, and people with moderate or mild degree of renal insufficiency need to take 5 mg of the drug once a day. If no effect is observed, and the drug is tolerated without complications, the dosage is increased to 10 mg. The size of the maximum portion per day is 10 mg.
[3]
Use Zolsana during pregnancy
There is too little information regarding the safety of zolpidem use in lactating or pregnant women. Therefore, it is not prescribed in these periods (especially in the 1st trimester). If Zolsana is prescribed to a woman of reproductive age, she should be warned about the need to cancel the medication and notify her doctor if she planned to become pregnant.
If the medication is used at a late stage of pregnancy or during labor, the newborn may develop hypothermia, decrease pressure and moderate respiratory depression (due to drug effects of the drug).
Contraindications
Among the contraindications:
- severe intolerance associated with drug elements;
- failure of the liver in the severe stage;
- sleep apnea;
- severe respiratory failure;
- myasthenia;
- acute alcohol poisoning or a chronic form of alcoholism.
Side effects Zolsana
Often, the use of drugs leads to headaches, feelings of confusion or drowsiness, a decrease in emotionality, and also dizziness, gastrointestinal disturbances (nausea, diarrhea or vomiting), vertigo, rashes, diplopia or amnesia, as well as weakened attention.
Anterograde amnesia may be observed, especially if large portions of the drug are used, against which inappropriate behavior is noted. Depression may develop or the symptoms of an already existing depression potentiate. Elderly people often develop mental signs of a paradoxical nature: a feeling of excitement, aggressiveness, anxiety or irritability, behavioral disorders, nightmares, hallucinations, anger and psychosis, as well as obsessive ideas.
At times, muscle weakness, feeling tired or ataxia appears.
Rarely observed weakening of the libido. These symptoms develop at the initial stage of therapy and disappear after repeated use of the drug.
The use of even therapeutic portions of the drug can cause physical dependence: the abolition of drugs can cause withdrawal syndrome.
Mental dependence can also occur along with drug abuse.
[2],
Overdose
Signs of poisoning include dizziness, nausea, ataxia, visual disturbances, bradycardia, and respiratory distress. In addition, drowsiness, unstoppable vomiting, convulsions, loss of consciousness, inappropriate behavior, as well as treatable coma.
Gastric lavage, the use of activated carbon, the implementation of symptomatic and supportive procedures are required (it is necessary to constantly monitor the work of the cardiovascular system and respiration). At the same time, it is necessary to abandon the use of any sedative drugs, even if the patient is agitated.
Zolpidem cannot be excreted by dialysis.
Interactions with other drugs
Combination with hypnotics, anticonvulsants, neuroleptics, antidepressants, and in addition with muscle relaxants, anesthetics, antihistamine sedative drugs and opioid analgesics can potentiate the hypnotic effect. Combination with opioid analgesics can potentiate the feeling of euphoria, which increases mental addiction.
Substances with a powerful inducing effect on the enzymes of hemoprotein 450 potentiate the metabolic decomposition of zolpidem, due to which its plasma values drop (almost 60%), and the drug efficacy is weakened.
Use together with inhibitors of the activity of the components of CYP 3A4 (excluding itraconazole) can provoke an increase in the plasma values of zolidedem and potentiation of drug effect.
For the period of use of Zolsana, it is necessary to abandon the use of alcohol, because it potentiates the sedative activity of zolpidem.
Storage conditions
Zolsana should be kept in a place closed to children. Temperature values - not higher than 25 ° C.
[6]
Shelf life
Zolsana can be used for a 5-year period from the time the medication is manufactured.
Application for children
Zolsana is not appointed until the age of 18.
A newborn baby, if its mother used drugs at the last stage of pregnancy, may experience withdrawal symptoms due to the occurrence of physical dependence.
[7]
Analogs
Analogues of the drug are substances Hypnogen, Zolpidem, Nitrest with Zonadine, and in addition, Dreamer and Ivadal with Sanval.
Attention!
To simplify the perception of information, this instruction for use of the drug "Zolsana" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.