Zolerer

Zolser has anti-ulcer activity.

Indications Zolser

Used for these disorders:

• ulcerative lesions affecting the gastrointestinal tract (also to prevent recurrence);
• reflux esophagitis;
• conditions with increased secretory activity (stress-related ulcers in the gastrointestinal tract, gastrinoma, polyendocrine adenomatosis and general mastocytosis);
• gastropathy associated with the use of NSAIDs.

The destruction of Helicobacter pylori in infected people with ulcers of the gastrointestinal tract (as an integral part of complex treatment).

Release form

The release of the substance is realized in enteric capsules having a volume of 20 mg. Inside the cell packaging - 10 capsules; in the box - 10 packs.

Pharmacodynamics

The drug is a hydrogen pump blocker, reduces the production of acid, slowing down the action of H ⁺ / K ⁺ -ATP-ases inside the parietal gastric glandulocytes, which prevents the final phase of the release of HCl. Zolser is a prodrug that acquires activity within the acidic environment of the excretory tubules of the parietal glandulocytes. Without being tied to the origin of the stimulus, decreases the stimulated and basal secretion.

The anti-excretion effect after consuming 20 mg of a substance develops over 60 minutes, reaching a peak after 120 minutes. A slowdown of 50% of the maximum excretory processes lasts 24 hours.

A single dose per day leads to an effective and rapid suppression of the secretory function of the stomach (day and night). The maximum effect develops after 4 days, and disappears by the end of the 3-4th day after the completion of the use of the drug.

In people with ulcers in the duodenum, the support of intragastric pH at around 3 after administration of 20 mg of the drug lasts 17 hours.

[1], [2], [3], [4]

Pharmacokinetics

Absorption of the drug from the small intestine is complete. The total values of the bioavailability of the drug after the introduction of the first portion are equal to 35%, and when reapplied they increase to almost 60%. Eating does not affect the level of bioavailability of drugs. The severity of inhibition of excretion processes is determined by AUC.

Intlasma protein synthesis - approximately 95%.

Almost the entire drug undergoes intrahepatic metabolic processes. Metabolic products (sulfide with sulfone, as well as hydroxyomeprazole) do not have a significant effect on the release of hydrochloric acid.

About 80% of metabolic products are excreted in the urine, and the remainder is excreted in the feces. The average half-life is approximately 40 minutes. This indicator does not change in case of repeated administration of Zolser.

[5],

Dosing and administration

Capsules are used orally, often in the morning, without chewing, with ordinary water (this happens immediately before eating or during meals).

In case of exacerbation of reflux esophagitis, ulcers or gastropathy associated with the introduction of NSAIDs, you need to use 20 mg of the drug 1-fold per day. Persons with severe reflux esophagitis are given a portion of up to 40 mg of a substance with a single dose per day.

Therapy for intestinal ulcers lasts for 2-3 weeks (if required, extend to 4-5 weeks). When esophagitis or gastric ulcer requires a 1-2-month course.

People who are resistant to the use of other anti-ulcer drugs are required to take 40 mg of the drug per day. The treatment cycle for intestinal ulcer lasts 1 month; with gastric ulcer or reflux esophagitis requires 2 months of therapy.

When gastrinoma apply 60 mg of the drug. If required, the portion is increased to 80-120 mg per day (in such circumstances, the dosage is divided into 2-3 use).

To prevent recurrences of ulcers, use 10 mg of the drug 1 time per day.

When destroying Helicobacter pylorus, the following schemes are applied:

• “Triple” treatment is a 7-day course in which 20 mg of omeprazole, 1000 mg of amoxicillin and 0.5 g of clarithromycin are used 2 times a day. It can be used (also 2 times a day) in 20 mg of omeprazole, 0.4 g of metronidazole and 0.25 g of clarithromycin. Another scheme is 1-time intake of 40 mg of omeprazole, as well as 3-fold intake of 0.5 g of amoxicillin and 0.4 g of metronidazole;
• "Double" treatment - a 14-day course, during which use 20-40 mg of omeprazole and 0.75 g of amoxicillin, 2 times a day. A cycle can be performed with 1-fold administration of 40 mg of omeprazole and 3-time intake of 0.5 g of clarithromycin per day (or 750-1500 mg of amoxicillin 2 times per day).

People with liver failure need to take 10-20 mg medication.

[9],

Use Zolser during pregnancy

Do not use the medicine during lactation or pregnancy. If a lactating woman needs to take the drug, you need to abandon breastfeeding.

Contraindications

It is contraindicated to appoint people with ulcerative rebirth, having a malignant nature.

[6], [7]

Side effects Zolser

The introduction of capsules can provoke the development of certain side effects:

• digestive disorders: nausea, diarrhea or obstipation, pain in the abdominal area, bloating and vomiting. Occasionally, an increase in liver enzymes occurs or a taste disorder develops. Perhaps the appearance of stomatitis or dryness of the oral mucosa. In individuals with severe liver disease previously observed, severe hepatitis (sometimes accompanied by jaundice) or a disorder of hepatic activity may occur;
• problems affecting the hematopoietic system: possible thrombocyto-, pancyto- or leukopenia, as well as agranulocytosis;
• disorders associated with the work of NA: people with somatic pathologies of a severe nature that are present in the background appear headaches, depression, arousal and dizziness. Persons with a previous severe hepatic disease develop encephalopathy;
• pathology in the field of musculoskeletal system: myasthenia, arthralgia or myalgia may occur;
• lesions of the epidermal layer: occasionally itching or rash appears. MEE, photosensitivity or alopecia may also develop;
• signs of allergy: angioedema, anaphylaxis, urticaria, and in addition bronchial spasm, fever and tubulointerstitial nephritis;
• other disorders: occasionally malaise, hyperhidrosis, gynecomastia, visual disturbances, peripheral edema. In addition, during long-term treatment, glandular cysts form inside the stomach (due to the slowing down of the HCl release process; this disorder is treatable and has a benign character).

[8],

Overdose

Manifestations of intoxication: visual impairment, nausea, feeling of confusion or drowsiness, and in addition, headaches, arrhythmia, severe dryness affecting the oral mucosa, and tachycardia.

Symptomatic interventions are carried out. Hemodialysis does not have sufficient effect.

Interactions with other drugs

The drug is able to significantly weaken the absorption of ampicillin esters, ketoconazole with itraconazole and iron salts (omeprazole leads to an increase in gastric pH).

Because the drug slows down the activity of hemoprotein P450, it is able to increase the values of indirect anticoagulants, diazepam and phenytoin (substances whose hepatic metabolic processes take place with the participation of CYP2C19 hemoprotein) and reduce their excretion. In such cases, it may sometimes be necessary to lower portions of these medicines.

In this case, long-term intake of 20 mg of omeprazole 1 time per day along with theophylline or naproxen, and with it caffeine, metoprolol or piroxicam, propranolol, or diclofenac, cyclosporine, ethyl alcohol, and also estradiol with quinidine or lidocaine does not cause changes in their plasma parameters.

Zolser potentiates the slowing effect exerted by other medicines on hematopoietic function.

[10], [11]

Storage conditions

Zolser is required to keep in a closed and out of reach of small children, dark and dry place. Temperature is standard.

Shelf life

Zolser can be applied within a 24-month period from the date of manufacture of the therapeutic substance.

Application for children

In pediatrics, Zolser is not prescribed (except in cases of vital need).

[12]

Analogs

Analogues of the drug are Losec, Orthanol with Omez and Ultop with Omeprazole.

[13]