Treatment of cystitis Furadonin: how to take, how many days to drink?

Effective drug for the treatment of inflammation of the urinary bladder is Furadonin. With cystitis, he stops the reproduction of bacteria and accelerates recovery.

Cystitis is one of the most common diseases of the genitourinary system among women. According to medical statistics, about 80% of cases are female. A painful condition arises from a variety of pathological causes that lead to inflammation of the mucous membrane of the bladder.

Treatment depends on a number of factors that are classified according to the following criteria:

• Type of pathogen: bacterial (chlamydia, ureaplasma, gonorrhea, staphylococcus, streptococcus and others) and non-bacterial (toxic, medicinal, allergenic).
• The nature of the current: acute and chronic.
• Morphological changes in the body: ulcerative, catarrhal, cystic.
• Localization of pathology: mucous membrane of the bladder, submucosal layer, muscle layer.

Several specialists are treating the treatment at the same time: urologist, nephrologist and gynecologist. With a properly selected therapy regimen, recovery occurs in 7-12 days. Most often the disease develops because of the action of pathogens. For their destruction, specific therapy with antibacterial and antimicrobial drugs is carried out.

Furadonin is an antimicrobial agent from the pharmacological group of nitrofurans. Each tablet contains 50/100 mg of active ingredient nitrofurantoin. The active component disrupts the permeability of cell membranes and protein synthesis in bacterial cells. It has bacteriostatic and bactericidal action.

The drug exhibits high activity against gram-negative and gram-positive bacteria. The most effective for such pathogens: Streptococcus spp., Staphylococcus spp., Salmonella paratyphi A, Salmonella typhi, Salmonella paratyphi B, Escherichia coli, Enterobacter spp., Proteus, Shigella sonnei. The drug is over-the-counter, but it should be taken only by agreement with the doctor in charge.

Rapid treatment of cystitis with furadonin

Cystitis is an unpleasant disease that both women and men face. It manifests as discomfort in the lower abdomen, painful urination and a burning sensation in the genitals. It is better to treat the disease in the early stages, because as inflammation progresses the inflammation turns into a chronic form.

The choice of method of therapy depends on the cause of the disease: infection, hypothermia, fungal infection. To select an effective drug and determine the cause of the disorder, urine analysis is shown.

If the inflammation is caused by an infection, then antimicrobial and antibiotic agents are indicated. Furadonin is one of the most effective drugs for the rapid treatment of cystitis. The medicine not only fights against infection, but also stops the inflammatory process. Has a wide spectrum of antimicrobial action. It is used only for medical purposes, as it can cause adverse reactions and has contraindications.

Indications Furadonin in cystitis

Furadonin is an antimicrobial agent from the pharmacological group of nitrofurans. The main indications for its use are infectious and inflammatory diseases of the urinary tract caused by drug-sensitive microorganisms:

• Cystitis.
• Pyelitis.
• Urethritis
• Pyelonephritis.

Also, the drug is used as a preventive agent for urological operations, cytoscopy, catheterization.

Furadonin in acute cystitis

Very often inflammation of the bladder proceeds in an acute form. An unpleasant condition is manifested by frequent and painful urination, the presence of pus, blood, subfebrile body temperature in urine.

Treatment should be comprehensive. Furadonin in acute cystitis is prescribed with systemic anti-inflammatory, diuretic and antibacterial drugs. The action of the drug is aimed at the destruction of pathogenic microorganisms and the reduction of inflammation. Interaction with other drugs provides a stable therapeutic effect for a short period of time. The average course of treatment is 5-7 days.

[1]

Release form

The drug is intended for oral administration and has two forms of release:

• Tablets, covered with enteric coating in the package of 12, 20, 30, 40 and 50 pieces.
• Suspension with a measuring cup or spoon.

The choice of the form of release depends on the patient's age and the duration of the planned therapy.

Tablets from cystitis furadonin

An obligatory component of the treatment of inflammation of the urinary bladder is medical therapy. If the disease is associated with infectious factors, then antibacterial and antimicrobial tablets are prescribed for cystitis. Furadonin is the last.

The drug has a broad spectrum of action and is part of the group of nitrofurans. It stops the reproduction of microbes and destroys them. It is used for urinary tract infections.

The tablets are covered with an enteric coating, so after ingestion they are well absorbed from the digestive tract. Active substances penetrate the placenta, into the cerebrospinal fluid and breast milk, so the drug has limitations on use during pregnancy and for patients of childhood.

[2]

Furadonin avexima

The pharmaceutical company of the full cycle of Avexima is engaged in the development and production of medical products, substances and medicines of various spectrum of action. The enterprise produces more than 30 names of ready-made medicinal forms, including Furadonin Avexima.

Antimicrobial is used to treat infections of the urinary tract. There is activity against gram-positive and gram-negative microorganisms. It is well absorbed from the digestive tract, bioavailability is about 50%, bonding to plasma proteins is 60%. Metabolized in the liver and muscle tissue, completely excreted by the kidneys.

• Indications for use: bacterial infections of the urinary tract, the prevention of infections in urological operations and diagnostic manipulation.
• Dosage and administration: by mouth, with plenty of liquid. Adults on 100-150 mg 3-4 times a day. The dose for children is 5-8 mg / kg, divided into 4 divided doses per day. The maximum single dose is 300 mg, the maximum daily dose is 600 mg. The duration of treatment for acute infections is 7-10 days.
• Side effect: nausea, vomiting, allergic reactions, increased drowsiness, dizziness and headaches, coughing and other.
• Contraindications: hypersensitivity to the components of the drug, chronic renal failure, cirrhosis, acute porphyria, heart failure 2-3 degrees, age less than 3 years, pregnancy and lactation.
• Overdose: nausea and vomiting, allergic reactions. For treatment, it is recommended that a large amount of liquid be taken to remove the drug as soon as possible.

Furadonin Avexima is a non-prescription medication, but it should be used for medical purposes.

Pharmacodynamics

A drug from the group of nitrofurans with antimicrobial properties. It breaks the permeability of cell membranes and protein synthesis in bacteria. It has bacteriostatic and bactericidal action.

Highly active against Gram-negative and Gram-positive microorganisms, especially Streptococcus spp., Staphylococcus spp., Salmonella paratyphi A, Salmonella typhi, Salmonella paratyphi B, Escherichia coli, Enterobacter spp., Proteus, Shigella sonnei.

The active substance - nitrofurantoin, belongs to the group of nitrofuran, uroantiseptic. Creates elevated concentrations in urine, which is especially effective in cases of urinary tract damage.

How quickly does furadonin help with cystitis?

According to reviews of many patients who were prescribed Furadonin for cystitis, the therapeutic effect manifests itself 3-4 hours after its administration. The active components act only on the excretory system, without affecting the intestine and other organs. Due to this, the inflammatory process and other painful symptoms are reduced.

The drug has a wide range of antimicrobial effects. To completely destroy the infection, the drug should be taken 5-7 days. If the tablets are used for prophylactic purposes, then take 1 capsule before bedtime for 3 days.

Pharmacokinetics

After ingestion, nitrofurantoin is rapidly absorbed into the digestive tract. Bioavailability of about 50%, food intake increases this value. Binding to blood plasma proteins is 60-95%. The active components are partially metabolized in the liver. About 30% is excreted unchanged in the urine, as the drug has a bacteriostatic and bactericidal effect on the urinary tract.

Therapeutic concentrations in tissues and blood do not arise. Half-life is about 60 minutes. A high level of nitrofurantoin in the urine persists for 12 hours. The components of the drug penetrate the placental and blood-brain barrier, as well as into breast milk.

Dosing and administration

The drug is taken orally during or after a meal, washing down with a large amount of water. Dosage depends on the characteristics of the course of cystitis. For adults and patients over 12 years of age, the following doses are recommended:

• Acute infections: 100 mg 2 times a day for a week.
• Severe chronic recurrent infections: 100 mg 3-4 times a day for 7 days.
• Prevention of infections during surgical interventions and diagnostic manipulations: 100 mg 2 times a day of the procedure and 3 days after.

Dosage for children younger than 12 years is calculated at 5-8 mg / kg per day, divided into 4 doses. The maximum single dose is 300 mg, the daily dose is 600 mg. The duration of treatment depends on the severity of the disease state.

How correctly to drink furadonin at a cystitis?

The treatment regimen is selected individually for each patient. According to the instructions for use, Furadonin should be taken 1-2 tablets (100-150 mg) 3-4 times a day. Duration of therapy is 5-10 days. At the same time the earlier treatment is initiated, the higher the therapeutic effect. Many patients note the relief of a painful condition for 2-3 days. Despite the positive results, treatment can not be stopped, as the disease can recur or go into chronic form.

Applying a drug, it is necessary to take into account a number of features of antimicrobial therapy:

• With caution, the drug is prescribed for patients with impaired renal function. Reduced excretion of the active substance and a violation of its concentration in urine may increase the level of nitrofurantoin in blood plasma. It is dangerous to intoxication of the body.
• It is used with caution for the treatment of patients with anemia, endocrine diseases, electrolyte imbalance and B group vitamins, with lung diseases, general exhaustion of the body.
• With prolonged treatment, it is necessary to monitor the function of breathing, especially in elderly patients, since there is a risk of worsening of pulmonary reactions.
• With prolonged therapy, it is necessary to monitor the liver function and the blood picture. There is a risk of developing chronic hepatitis and cholestatic jaundice.
• The medication disrupts the normal microflora of the colon, so it can cause diarrhea caused by Clostridium difficile.
• In rare cases, prolonged therapy leads to bacterial resistance. To normalize the condition, stop taking the drug and pick up another antibacterial agent.

Furadonin does not affect psychomotor reactions when working with mechanisms or during the management of motor vehicles.

[6]

How many days does furadonin take with cystitis?

In order for the antimicrobial agent to have the maximum therapeutic effect without harm to the body, it is necessary to choose the right dosage and duration of therapy. If the cystitis occurs without complications, then this treatment scheme is shown:

• Children under 12 years of age - 5-8 mg / kg per day. The dose is divided into 4 divided doses.
• Patients over 12 years of age - 100 mg 2-3 times a day.
• Persons over 16 years of age - 100 mg 4 times a day for 7 days.

On average, the pills are drunk for 5 to 10 days. If the medicine is used for preventive purposes, then it can be a single dose of 100 mg or longer duration of therapy.

When using Furadonin, it is important to take it correctly. Tablets are consumed during or immediately after a meal. Capsules are not chewed and washed down with plenty of water. If the next appointment was missed, then the next one goes without changing the dosage. In most patients, relief from a painful condition is observed after 2-3 days of treatment.

Furadonin for the prevention of cystitis

In the treatment of infectious inflammation of the bladder, special attention is paid to preventive measures. To prevent exacerbations of cystitis, a maintenance dose of Furadonin is recommended - 50-100 mg once a day, preferably at bedtime.

The duration of such therapy is determined by the doctor. As a rule, prevention lasts from 3 to 12 months. In addition to drug therapy, it is important to follow basic rules of personal hygiene and adhere to a sparing diet. This allows you to significantly reduce the risk of recurrence of the infection.

Furadonin in women with cystitis

Inflammation of the bladder is most often diagnosed in women. The prevalence of cystitis is explained by their anatomical features. In women, the urinary tract is shorter than that of men, and the opening of the canal is near the anus, which leads to the entry of bacteria into the urethra. Also, the disease is closely related to hormonal changes in the female body.

For treatment use anti-inflammatory, antibacterial and other medications. If the inflammation is caused by an infection, then antimicrobial agents are used. Furadonin belongs to this category of drugs. It has bacteriostatic and bactericidal properties. Effective in acute and chronic cystitis. As a rule, women are prescribed 100-150 mg 3-4 times a day for 5-7 days. Also, the medicine can be used to prevent inflammation.

Furadonin in men with cystitis

The prevalence of cystitis among men is much lower than that of women. With the inflammation of the bladder, patients older than 40 years are more likely to face. The disease can be caused by urological problems, that is, develop after having suffered inflammatory or infectious diseases.

The intake of medications is an indispensable component of therapy and practically does not differ from the treatment of women. Furadonin is effective in cystitis caused by pathogens: gram-positive and gram-negative aerobic bacteria.

Tablets are taken orally. Dosage and duration of treatment depends on the features of the course of the disease. If the inflammation is uncomplicated, then appoint 100-150 mg 3-4 times a day for 5-10 days. Relief of the painful condition is observed on the 2-3 day of treatment.

Furadonin for children with cystitis

Treatment of cystitis in pediatric practice has a number of difficulties, since many effective drugs are contraindicated. With regard to Furadonin, its use for children under 12 years of age should be reasonably strong. The drug is prohibited for children under 1 month of age.

Dosage for patients under 12 years is calculated at 5-7 mg / kg per day. The daily dose is divided into 4 equal doses. For children over 12 years - 100 mg 2-3 times a day. Duration of treatment is 5-7 days.

Read also about the analogues of Furadonin.

Use Furadonin in cystitis during pregnancy

The use of nitrofuran derivatives is contraindicated for the treatment of pregnant women in the early stages of gestation. Despite the fact that Furadonin refers to drugs with low toxicity, its active substance penetrates through the placental barrier and can have a toxic effect on the fetus. It is dangerous for intrauterine mutations and other disorders of fetal development.

The drug is allowed from the second trimester and in very small doses - 0.1-0.5 mg 3-4 times a day. When using medicament during lactation, breastfeeding should be discontinued because the active ingredients penetrate into the mother's milk. The decision on the appropriateness of using an antimicrobial agent should be made by the attending physician, taking into account the expected therapeutic effect for the woman and the risks for the child.

Contraindications

Furadonin is not allowed to be used in case of individual intolerance of its active components and other nitrofurans. Also, the drug is contraindicated in such cases:

• Chronic renal failure.
• Chronic heart failure of II-III degree.
• Cirrhosis of the liver.
• Chronic hepatitis.
• Acute porphyria.
• Insufficiency of glucose-6-phosphate dehydrogenase.
  Pulmonary fibrosis.
• Pyelonephritis.
• Oliguria.
• Anuria.
• Chronic hepatitis.
• Neuritis and polyneuropathy.

The drug is not used for treatment during pregnancy and lactation. Also prohibited for patients on hemodialysis and for children under 1 month of age.

Side effects Furadonin in cystitis

Failure to comply with recommendations for taking medication is dangerous by the development of various kinds of adverse reactions. An antimicrobial agent can cause such symptoms:

• Gastrointestinal tract: nausea, vomiting, violation of appetite, abdominal pain, diarrhea.
• Nervous system: headaches, dizziness, drowsiness, increased intracranial pressure.
• Immune system: hypersensitivity reactions and autoimmune reactions.
• Respiratory system: chest pain, shortness of breath, feverish condition.
• Liver and biliary tract: cholestatic jaundice, hepatitis.
• Skin and vessels: hyperemia, rashes, itching, angioedema, inflammation of the salivary glands.
• Hematopoietic and lymphatic systems: leukopenia, thrombocytopenia, hemolytic anemia.

Most often, side effects develop when the dosage and duration of therapy are not adhered to. The appearance of the above symptomatology requires medical advice and a temporary refusal to take tablets.

[3], [4], [5]

Overdose

Long-term use of the drug or excess of the dose prescribed by the doctor is dangerous by the development of adverse reactions. Most often, an overdose manifests itself by such symptoms:

• Nausea.
• Vomiting.
• Headache and dizziness.
• Polyneuritis.
• Skin allergic reactions.

There is no specific antidote. For treatment, it is recommended that large volumes of liquid be taken to accelerate the excretion of the drug. Also it is necessary to take enterosorbents, antihistamines, preparations of group B. In especially severe cases it is necessary to wash the stomach or hemodialysis.

Interactions with other drugs

Very often for the treatment of inflammation of the bladder a complex of various medicines is used, which complement each other and eliminate the cause of the disease. When designing the therapy scheme, the possibility of interaction of all drugs and the risk of developing side effects are taken into account.

When using Furadonin, its compatibility with such agents should be considered:

• Antacids and preparations of nalidixic acid reduce the antibacterial effect of the drug.
• Incompatible with fluoroquinolones, as they block tubular secretion, reducing the concentration of nitrofurantoin in the urine and reducing its therapeutic effects. This increases the toxicity of the drug.
• Urikozuricheskie means increase the concentration of nitrofurantoin in the blood at the expense of violation of its withdrawal. This reduces the antimicrobial effect of the drug and increases its toxicity.
• Interaction with contraceptives leads to a decrease in contraceptive effect.
• Inhibitors of carbonic anhydrase significantly reduce the antibacterial activity of the drug.
• Antibacterial effect of nitrofurantoin decreases in alkaline urine, therefore, it should not be combined with means that raise the pH of urine.
• At simultaneous application with penicillins and cephalosporins the antibacterial effect of all preparations raises. It interacts well with tetracycline and erythromycin.

During treatment it is forbidden to use any alcohol-containing beverages, as they increase the manifestation of adverse reactions and reduce the effectiveness of nitrofurantoin.

[7]

Storage conditions

Tablets Furadonin must be stored in an individual package, in a dry place, protected from sunlight and inaccessible to children. Recommended storage temperature is not higher than 25 ° С. Violation of storage conditions leads to premature deterioration of the drug.

[8]

Shelf life

According to the instructions for use, the expiration date of the antimicrobial agent is 60 months (5 years) from the date of its production. After this period, Furadonin should be disposed of. Overdue medication is prohibited for use as it can cause uncontrolled adverse reactions.

Reviews

Many patients who take Furadonin with cystitis leave positive reviews about this drug. The drug has a relatively low cost, but effectively copes with inflammation caused by pathogens. It is also noted that increased doses of the drug and its long-term use cause side reactions from the intestine (nausea, vomiting, abdominal pain) and the nervous system.